Effects of STZ-Induced Diabetes on the Relative Weights of Kidney, Liver and Pancreas in Albino Rats: A Comparative Study

Abstract

Efectos de la Diabetes Inducida por STZ en los Pesos Relativos de Riñón, Hígado y Páncreas en Ratas Albinas: un Estudio Comparativo * Muhammad Zafar & ** Syed Naeem-ul-Hassan Naqvi ZAFAR, M. & NAEEM-UL-HASSAN NAQVI, S. Effects of STZ-Induced diabetes on the relative weights of kidney, liver and pancreas in albino rats: a comparative study. Int. J. Morphol., 28(1):135-142, 2010. SUMMARY:We studied the effects of streptozotocin (STZ)-induced diabetes on the body weights of animals and the relative weights of kidney, liver and pancreas in albino rats. The aim of the study was to find an association between the reduction in the body weights of diabetic animals and the relative weights of kidney, liver and pancreas in proportion to the body weight of animals in albino rats. This study was performed in the Surgeons (CPSP) Pakistan in 2007-08. Diabetes was induced by a single dose of STZ (45 mg/kg, b.w.) given intraperitoneally in sodium citrate buffer at pH 4.5. Eighty albino rats were divided into five groups: control (A) and STZ treated (B, C, D, and E) which were sacrificed 2, 4, 6 and 8 weeks post treatment respectively. All the animals were weighed prior to the administration of streptozotocin and at sacrificial time. Kidney, liver and pancreas were removed, dried and weighed on Sartorius balance. The body weights of animals in different groups changed at variable time intervals. The Kidney weight was significantly increased, liver weight was slightly increased while the weight of pancreas was unaffected when compared with the weight of diabetic animals. It seems that the STZ-induced diabetes causes a significant reduction in the body weight of diabetic animals while the relative weights of kidney and liver were increased and the weight of pancreas was unaffected.

Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed

“…This shows that Garcinia kola has the same function as glibenclamide used in the treatment of diabetes. Just like (17) observed that the diabetic non treated rats looked ill, polydipsia, the relative weights of kidney and liver were increased and the weight of pancreas was unaffected; our diabetic untreated rats showed similar sign of ill looking and polydipsia though their kidney, liver and pancreas were not weighed.…”

Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through activation of AMPK signaling pathway

“…Furthermore, the evaluation of histopathological studies demonstrated that activate AMPK signaling pathway attenuate the kidney tissue damage that is caused by STZ-diabetes. STZ-induced type 1 diabetic rats are associated with severe decrease of body weight caused by hyperglycemia, loss of tissue proteins (14), muscular tissue and adipose tissue (15). Additionally, the increase in the levels of serum uric acid and creatinine (16) and the decrease in the levels of serum albumin and total protein (17) have been associated with diabetic kidney disease.…”

Bone Marrow-Derived Mesenchymal Stem cells Infusion Ameliorates Hyperglycemia, Dyslipidemia, Liver and Kidney Functions in Diabetic Rats

“…Moreover, Zafar and Naqvi [42] and Saumya and Basha [43], reported that STZ decompose inside the cell to form carbonium ions that alkylate DNA and decrease cellular nicotinamide adenine nucleotide (NAD) level which may adversely affect beta cells by interrupting respiratory enzyme activity and alteration of their mitochondrial function leading to irreversible cellular necrosis and death of beta cells resulting in permanent hyperglucemia, this changes lead to suppression and disturbance of biosynthesis and insulin secretion. Moreover, Cemek et al [44] also found that hyperglycemia is due to irreversible destruction of beta islet cells of the pancreas by STZ, causing a reduction of insulin secretion (hypoinsulinemia).…”