Effects of structural property and surface modification of Ti6Ta4Sn scaffolds on the response of SaOS2 cells for bone tissue engineering

Li, Yuncang; Xiong, Jianyu; Hodgson, Peter; Wen, Cuié

doi:10.1016/j.jallcom.2010.01.026

Cited by 35 publications

(26 citation statements)

References 56 publications

(78 reference statements)

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“…This is because there was a geometrical correlation between large pore sizes and less surface area available for the cells to attach to. A similar effect has been observed in other studies in which porous scaffolds of 400m presented enhanced levels of cell attachment for larger levels of porosity [17]. Scaffolds of pore size 212-300m (A3, B3) did not appear to promote cell growth beyond day 7, and in particular B3 yielded the worst performing results from the entire set ( Figure 7, bottom row).…”

Section: Structural and Mechanical Propertiessupporting

confidence: 87%

“…An optimum size cannot be concluded from the results as this value seems highly dependent on the conditions of the study (e.g. 25 and 200m had the most positive effect in a range 25-500m [15], 325m when studying 85-325m [16], 400m was preferred when the range studied was 75-900m [17] and 600m in a 300-1000m range [12]). …”

Section: Introductionmentioning

confidence: 99%

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The effect of pore size and porosity on mechanical properties and biological response of porous titanium scaffolds

Torres-Sánchez

Mushref

Norrito

et al. 2017

Materials Science and Engineering: C

151

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The effect of pore size and porosity on elastic modulus, strength, cell attachment and cell proliferation was studied for Ti porous scaffolds manufactured via powder metallurgy and sintering. Porous scaffolds were prepared in two ranges of porosities so that their mechanical properties could mimic those of cortical and trabecular bone respectively.Space-holder engineered pore size distributions were carefully determined to study the impact that small changes in pore size may have on mechanical and biological behaviour. The Young's moduli and compressive strengths were correlated with the relative porosity.Linear, power and exponential regressions were studied to confirm the predictability in the characterisation of the manufactured scaffolds and therefore establish them as a design tool for customisation of devices to suit patients' needs. The correlations were stronger for the linear and the power law regressions and poor for the exponential regressions. The optimal pore microarchitecture (i.e. pore size and porosity) for scaffolds to be used in bone grafting for cortical bone was set to <212m with volumetric porosity values of 27-37%, and for trabecular tissues to 300-500m with volumetric porosity values of 54-58%. The pore size range 212-300m with volumetric porosity values of 38-56% was reported as the least favourable to cell proliferation in the longitudinal study of 12 days of incubation.

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Section: Structural and Mechanical Propertiessupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

The effect of pore size and porosity on mechanical properties and biological response of porous titanium scaffolds

Torres-Sánchez

Mushref

Norrito

et al. 2017

Materials Science and Engineering: C

151

View full text Add to dashboard Cite

show abstract

“…Also, Ti6Ta4Sn scaffolds have been studied by Li et al 198 In this study, the cell adhesion density was directly proportional to pore sizes in the range of 25–75%, but was inversely proportional in the range of 75–900 μ m. Surface modification by different treatments enhanced osteoblast-like cell adhesion.…”

Section: Methodsmentioning

confidence: 71%

Scaffold Design for Bone Regeneration

Polo-Corrales¹,

Latorre-Esteves²,

Ramı́rez-Vick³

2014

j. nanosci. nanotech.

770

502

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The use of bone grafts is the standard to treat skeletal fractures, or to replace and regenerate lost bone, as demonstrated by the large number of bone graft procedures performed worldwide. The most common of these is the autograft, however, its use can lead to complications such as pain, infection, scarring, blood loss, and donor-site morbidity. The alternative is allografts, but they lack the osteoactive capacity of autografts and carry the risk of carrying infectious agents or immune rejection. Other approaches, such as the bone graft substitutes, have focused on improving the efficacy of bone grafts or other scaffolds by incorporating bone progenitor cells and growth factors to stimulate cells. An ideal bone graft or scaffold should be made of biomaterials that imitate the structure and properties of natural bone ECM, include osteoprogenitor cells and provide all the necessary environmental cues found in natural bone. However, creating living tissue constructs that are structurally, functionally and mechanically comparable to the natural bone has been a challenge so far. This focus of this review is on the evolution of these scaffolds as bone graft substitutes in the process of recreating the bone tissue microenvironment, including biochemical and biophysical cues.

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“…Li and coworkers also evaluated various surface treatments of porous Ti6Ta4Sn, noting that a sol-gel HA coating yielded optimal adhesion of osteoblast-like cells. 51 …”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Biomaterials for Tissue Engineering

2013

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Biomaterials serve as an integral component of tissue engineering. They are designed to provide architectural framework reminiscent of native extracellular matrix in order to encourage cell growth and eventual tissue regeneration. Bone and cartilage represent two distinct tissues with varying compositional and mechanical properties. Despite these differences, both meet at the osteochondral interface. This article presents an overview of current biomaterials employed in bone and cartilage applications, discusses some design considerations, and alludes to future prospects within this field of research.

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Effects of structural property and surface modification of Ti6Ta4Sn scaffolds on the response of SaOS2 cells for bone tissue engineering

Cited by 35 publications

References 56 publications

The effect of pore size and porosity on mechanical properties and biological response of porous titanium scaffolds

The effect of pore size and porosity on mechanical properties and biological response of porous titanium scaffolds

Scaffold Design for Bone Regeneration

Biomaterials for Tissue Engineering

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