Effects of strontium substitution in synthetic apatites for biomedical applications

Alyousef, Nujood Ibrahim; AlMaimouni, Yara Khalid; Benrahed, Mashael Abdullah; Khan, Abdul Samad; Shahid, Shamsuddin

doi:10.1016/b978-0-08-102834-6.00013-6

Cited by 3 publications

(4 citation statements)

References 38 publications

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“…Of note, the osteogenesis/angiogenesis properties revealed to be much stronger in composite scaffolds than pure SIS, and particularly the osteogenesis/angiogenesis levels were further upregulated in SIS/SrFeHA with respect to SIS/SrHA (figures 5-6). These positive results verified enhanced osteogenesis/angiogenesis effects of SrHA incorporation and are basically corresponding to previous studies that moderate 10 mol% doped SrHA components can significantly motivate osteogenesis/ angiogenesis by promoting cellular proliferation, migration and osteogenic/angiogenic differentiation [47]. More importantly, the enhanced bioactivity of SIS/SrFeHA could be rationally attributed to the simultaneous releasing of Sr 2+ /Fe 3+ into extracts since the concentrations of released Ca/P were basically similar among groups (table S2).…”

Section: Discussionsupporting

confidence: 88%

“…More importantly, the enhanced bioactivity of SIS/SrFeHA could be rationally attributed to the simultaneous releasing of Sr 2+ /Fe 3+ into extracts since the concentrations of released Ca/P were basically similar among groups (table S2). It is wellknown that supplying either Sr 2+ or Fe 3+ in proper doses can potently induce osteogenesis/angiogenesis [47][48][49], while the excessive Sr 2+ /Fe 3+ concentrations will impede their positive effects and even result in cytotoxicity [50,51]. Herein, the concentrations of Sr 2+ and Fe 3+ released into scaffolds extracts were examined around 0.688 ± 0.159-0.837 ± 0.142 mg L −1 and ∼0.145 ± 0.059 respectively (table S2), which were exactly in a secure range and quite beneficial for osteogenic/angiogenic developments as disclosed formerly [49,52].…”

Section: Discussionmentioning

confidence: 99%

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Biomimetic porous scaffolds containing decellularized small intestinal submucosa and Sr²⁺/Fe³⁺ co-doped hydroxyapatite accelerate angiogenesis/osteogenesis for bone regeneration

et al. 2022

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The design of bone scaffolds is predominately aimed to well reproduce the natural bony environment by imitating the architecture/composition of host bone. Such biomimetic biomaterials are gaining increasing attention and acknowledged quite promising for bone tissue engineering. Herein, novel biomimetic bone scaffolds containing decellularized small intestinal submucosa matrix (SIS-ECM) and Sr2+/Fe3+ co-doped hydroxyapatite (SrFeHA) are fabricated for the first time by the sophisticated self-assembled mineralization procedure, followed by cross-linking and lyophilization post-treatments. The results indicate the constructed SIS/SrFeHA scaffolds are characterized by highly porous structures, rough microsurface and improved mechanical strength, as well as efficient releasing of bioactive Sr2+/Fe3+ and ECM components. These favorable physico-chemical properties endow SIS/SrFeHA scaffolds with an architectural/componential biomimetic bony environment which appears to be highly beneficial for inducing angiogenesis/osteogenesis both in vitro and in vivo. In particular, the cellular functionality and bioactivity of endotheliocytes/osteoblasts are significantly enhanced by SIS/SrFeHA scaffolds, and the cranial defects model further verifies the potent ability of SIS/SrFeHA to accelerate in vivo vascularization and bone regeneration following implantation. In this view these results highlight the considerable angiogenesis/osteogenesis potential of biomimetic porous SIS/SrFeHA scaffolds for inducing bone regeneration and thus may afford a new promising alternative for bone tissue engineering.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Biomimetic porous scaffolds containing decellularized small intestinal submucosa and Sr²⁺/Fe³⁺ co-doped hydroxyapatite accelerate angiogenesis/osteogenesis for bone regeneration

et al. 2022

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“…Comparatively, the bioactivity of Sr-HAP/GCN composites appears to be better. This is due to the interaction of Sr 2+ ions which has a larger ionic radii (1.18 Å) than Ca 2+ ions (1.00 Å) (23). The change in the pH of the SBF solution as a function of time is shown in Figure 6.…”

Section: Phase Content and Crystallinity Of Hap Hap/gcn And Sr-hap/gc...mentioning

confidence: 99%

Improving the Bioactivity of Hydroxyapatite Through Strontium Substitution and Forming a Composite with Graphitic Carbon Nitride

Saranya

Vishwapriya²,

Prasad³

et al. 2022

ECS Trans.

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To overcome the limitations of hydroxyapatite, such as low mechanical strength, inappropriate degradation rate, and poor biological response with respect to bone apatite and growing interest on Sr doped hydroxyapatite, due to the advanced bone recovery and improved bioactivity of Sr and the non-toxic, graphitic carbon nitride (GCN) towards the biomedical applications, the present work focuses on synthesis of HAP/GCN and Sr-HAP/GCN composites by chemical precipitation followed by the hydrothermal treatment. The characteristic properties of these composites were evaluated using scanning electron microscopy, X-ray diffraction measurements, and Fourier transform infrared spectroscopy. The bioactivity of HAP/GCN and Sr-HAP/GCN composites was evaluated by immersing them in simulated body fluid (SBF) at 37 ± 1°C for 14 days and the extent of formation of apatite on their surface is observed using optical microscope. When compared to HAP, HAP/GCN, and Sr-HAP/GCN, exhibit better bioactivity and among them Sr-HAP/GCN is promising for biomedical applications.

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“…La literatura hoy día recoge diversas investigaciones asociadas a la evaluación de la efectividad de las metodologías de síntesis de Sr-HA, estudios sobre el efecto que ocasiona la presencia de este ion en la estructura de la red cristalina de la hidroxiapatita y en sus propiedades, así como, reportes de ensayos de su evaluación in vitro o in vivo. Más allá de que los resultados de las aplicaciones de las Sr-HA han sido muy alentadores (13,14), las investigaciones continúan, y han motivado que estos biomateriales también se hayan considerado como propuestas de plataformas para la liberación de diversos principios activos, Figura 1.…”

Section: Introductionunclassified

Strontium-doped hydroxyapatite: platform for bone regeneration with antimicrobial activity

Morejón Alonso,

Rodríguez Montero,

Delgado García-Menocal

et al. 2024

Actual. Med.

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Hydroxyapatite (HA) is a calcium phosphate with great analogy to biological apatite. Because of that it has demonstrated excellent results in clinical applications for bone tissue replacement. However, there are certain pathologies such as osteopenia or osteoporosis where the natural bone formation capacity is diminished and which may require an extra stimulus to accelerate and guarantee the osseointegration processes. In these cases, doping hydroxyapatite with strontium ions (Sr-HA) has given excellent results. This ion participates in bone metabolism in various ways and, while stimulating osteosynthesis, it inhibits osteoclast to a certain extent, which as a whole promotes the formation of new bone more quickly. Thus, the development of Sr-HA implants has evolved to not only consider substitutes for bone tissue with greater speed of osseointegration, but also to become platforms for the release of other active ingredients that can also counteract different medical conditions. This work delves into the complexity of septic processes associated with prostheses, which justifies the diversity of approaches to this clinical problem from biomedical engineering. In addition, review different formulations based on Sr-HA reported to eradicate septic processes. In particular, it explores new devices carrying antibiotics (Antb/Sr-HA) and new platforms that have been formed from the double ion doping of the HA where one of those ions is strontium and the other is some metallic element with demonstrated antibacterial activity (M/Sr-HA).

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Effects of strontium substitution in synthetic apatites for biomedical applications

Cited by 3 publications

References 38 publications

Biomimetic porous scaffolds containing decellularized small intestinal submucosa and Sr²⁺/Fe³⁺ co-doped hydroxyapatite accelerate angiogenesis/osteogenesis for bone regeneration

Biomimetic porous scaffolds containing decellularized small intestinal submucosa and Sr²⁺/Fe³⁺ co-doped hydroxyapatite accelerate angiogenesis/osteogenesis for bone regeneration

Improving the Bioactivity of Hydroxyapatite Through Strontium Substitution and Forming a Composite with Graphitic Carbon Nitride

Strontium-doped hydroxyapatite: platform for bone regeneration with antimicrobial activity

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Effects of strontium substitution in synthetic apatites for biomedical applications

Cited by 3 publications

References 38 publications

Biomimetic porous scaffolds containing decellularized small intestinal submucosa and Sr2+/Fe3+ co-doped hydroxyapatite accelerate angiogenesis/osteogenesis for bone regeneration

Biomimetic porous scaffolds containing decellularized small intestinal submucosa and Sr2+/Fe3+ co-doped hydroxyapatite accelerate angiogenesis/osteogenesis for bone regeneration

Improving the Bioactivity of Hydroxyapatite Through Strontium Substitution and Forming a Composite with Graphitic Carbon Nitride

Strontium-doped hydroxyapatite: platform for bone regeneration with antimicrobial activity

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Biomimetic porous scaffolds containing decellularized small intestinal submucosa and Sr²⁺/Fe³⁺ co-doped hydroxyapatite accelerate angiogenesis/osteogenesis for bone regeneration

Biomimetic porous scaffolds containing decellularized small intestinal submucosa and Sr²⁺/Fe³⁺ co-doped hydroxyapatite accelerate angiogenesis/osteogenesis for bone regeneration