Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Baheiraei, Nafiseh; Eyni, Hossein; Bakhshi, Bita; Najafloo, Raziyeh; Rabiee, Navid

doi:10.1038/s41598-021-88058-1

Cited by 55 publications

(30 citation statements)

References 50 publications

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“…The increase in the level of Sr/CaP from 5 to 10 wt% (S10A10, S10A5) enhanced the growth inhibition of the planktonic S. mutans exhibited by the experimental orthodontic adhesives. It was speculated that the bacteriostatic action observed with the experimental orthodontic adhesives could be primarily due to the Sr-BGNPs since the potential benefits of Sr 2+ -release include both remineralizing and antibacterial actions 18 . This result was in accordance with those of previous studies that demonstrated the antibacterial actions of Sr-containing bioactive glasses 56 , 57 .…”

Section: Discussionmentioning

confidence: 99%

“…It was proposed that Sr 2+ could potentially enhance apatite precipitation by increasing the number of nucleation clusters 16 , 17 . Additionally, it was demonstrated that bioactive glass doped with Sr exhibited superior antibacterial actions compared to non-Sr-doped bioactive glass 18 . The antibacterial actions of Sr 2+ may involve the inhibition of the growth, cell wall synthesis, metabolism, and DNA replication of bacteria 18 .…”

Section: Introductionmentioning

confidence: 99%

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Physical/mechanical and antibacterial properties of orthodontic adhesives containing Sr-bioactive glass nanoparticles, calcium phosphate, and andrographolide

Chaichana

Insee

Chanachai

et al. 2022

Sci Rep

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White spot lesions around orthodontic brackets are the major complication during fixed orthodontic treatment. This study prepared orthodontic adhesives for promoting mineral precipitation and reducing bacterial growth. Adhesives with added calcium phosphate monohydrate/Sr-bioactive glass nanoparticles (Sr/CaP) and andrographolide were prepared. The physical/mechanical and antibacterial properties of the adhesives were tested. The additives reduced the monomer conversion of the materials (62 to 47%). The addition of Sr/CaP and andrographolide increased the water sorption (from 23 to 46 μg/mm3) and water solubility (from 0.2 to 5.9 μg/mm3) but reduced the biaxial flexural strength (from 193 to 119 MPa) of the adhesives. The enamel bond strengths of the experimental adhesives (19–34 MPa) were comparable to that of the commercial material (p > 0.05). The Sr/CaP fillers promoted Ca, Sr, and P ion release and the precipitation of calcium phosphate at the debonded interface. An increase in the Sr/CaP concentration enhanced the inhibition of S. mutans by 18%, while the effect of andrographolide was not detected. The abilities of the adhesives to promote ion release, calcium phosphate precipitation, and the growth inhibition of cariogenic bacteria were expected to reduce the occurrence of white spot lesions. The additives reduced the physical/mechanical properties of the materials, but the corresponding values were within the acceptable range.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physical/mechanical and antibacterial properties of orthodontic adhesives containing Sr-bioactive glass nanoparticles, calcium phosphate, and andrographolide

Chaichana

Insee

Chanachai

et al. 2022

Sci Rep

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“…Baheiraei et al observed that gelatin-Sr-bioactive glass scaffolds (Gel-BG/Sr) display in vitro antibacterial properties against Escherichia coli and, in comparison to counterparts having no Sr ions, also against Staphylococcus aureus . In addition, Gel-BG/Sr scaffolds demonstrated a more enhanced deposition of newly-formed bone tissue in a rabbit calvarial bone defect in comparison to Sr-free counterpart [ 138 ]. Beside silicate BGs, borate BGs have been recently considered as attractive materials for several biomedical applications.…”

Section: Biomaterials For Bone Tissue Engineering Approach and Their ...mentioning

confidence: 99%

Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View

et al. 2022

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Strontium (Sr) is a trace element taken with nutrition and found in bone in close connection to native hydroxyapatite. Sr is involved in a dual mechanism of coupling the stimulation of bone formation with the inhibition of bone resorption, as reported in the literature. Interest in studying Sr has increased in the last decades due to the development of strontium ranelate (SrRan), an orally active agent acting as an anti-osteoporosis drug. However, the use of SrRan was subjected to some limitations starting from 2014 due to its negative side effects on the cardiac safety of patients. In this scenario, an interesting perspective for the administration of Sr is the introduction of Sr ions in biomaterials for bone tissue engineering (BTE) applications. This strategy has attracted attention thanks to its positive effects on bone formation, alongside the reduction of osteoclast activity, proven by in vitro and in vivo studies. The purpose of this review is to go through the classes of biomaterials most commonly used in BTE and functionalized with Sr, i.e., calcium phosphate ceramics, bioactive glasses, metal-based materials, and polymers. The works discussed in this review were selected as representative for each type of the above-mentioned categories, and the biological evaluation in vitro and/or in vivo was the main criterion for selection. The encouraging results collected from the in vitro and in vivo biological evaluations are outlined to highlight the potential applications of materials’ functionalization with Sr as an osteopromoting dopant in BTE.

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“… 50–52 Of note, different biological components and stimuli are necessary at the correct time and place to provide practical and complicated vascularized tissues. 53 , 54 For example, porcine lung transplantation using a decellularized lung scaffold seeded with human endothelial and epithelial cells has been reported by Zhou et al to promote angiogenesis. 55 Interestingly, a decellularized goat-lung scaffold modified with a chitosan/nanohydroxyapatite composite was utilized for other tissue investigations, such as bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

Shokrani¹,

Shokrani²,

Sajadi³

et al. 2022

IJN

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One of the most arduous challenges in tissue engineering is neovascularization, without which there is a lack of nutrients delivered to a target tissue. Angiogenesis should be completed at an optimal density and within an appropriate period of time to prevent cell necrosis. Failure to meet this challenge brings about poor functionality for the tissue in comparison with the native tissue, extensively reducing cell viability. Prior studies devoted to angiogenesis have provided researchers with some biomaterial scaffolds and cell choices for angiogenesis. For example, while most current angiogenesis approaches require a variety of stimulatory factors ranging from biomechanical to biomolecular to cellular, some other promising stimulatory factors have been underdeveloped (such as electrical, topographical, and magnetic). When it comes to choosing biomaterial scaffolds in tissue engineering for angiogenesis, key traits rush to mind including biocompatibility, appropriate physical and mechanical properties (adhesion strength, shear stress, and malleability), as well as identifying the appropriate biomaterial in terms of stability and degradation profile, all of which may leave essential trace materials behind adversely influencing angiogenesis. Nevertheless, the selection of the best biomaterial and cells still remains an area of hot dispute as such previous studies have not sufficiently classified, integrated, or compared approaches. To address the aforementioned need, this review article summarizes a variety of natural and synthetic scaffolds including hydrogels that support angiogenesis. Furthermore, we review a variety of cell sources utilized for cell seeding and influential factors used for angiogenesis with a concentrated focus on biomechanical factors, with unique stimulatory factors. Lastly, we provide a bottom-to-up overview of angiogenic biomaterials and cell selection, highlighting parameters that need to be addressed in future studies.

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Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Cited by 55 publications

References 50 publications

Physical/mechanical and antibacterial properties of orthodontic adhesives containing Sr-bioactive glass nanoparticles, calcium phosphate, and andrographolide

Physical/mechanical and antibacterial properties of orthodontic adhesives containing Sr-bioactive glass nanoparticles, calcium phosphate, and andrographolide

Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

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