Effects of storage practices on long‐chain polyunsaturated fatty acids and lipid peroxidation of preterm formula milk

Nessel, Isabell; Khashu, Minesh; Dyall, Simon C.

doi:10.1111/jhn.12858

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…The abundance of polyunsaturated fatty acids greatly affected intracellular lipid peroxidation [ 69 ]. However, the substrate of lipid peroxidation is usually endogenous [ 70 ].…”

Section: New Approaches To Metal Ions-induced Cell Death and Their An...mentioning

confidence: 99%

New anti-cancer explorations based on metal ions

et al. 2022

J Nanobiotechnol

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Due to the urgent demand for more anti-cancer methods, the new applications of metal ions in cancer have attracted increasing attention. Especially the three kinds of the new mode of cell death, including ferroptosis, calcicoptosis, and cuproptosis, are of great concern. Meanwhile, many metal ions have been found to induce cell death through different approaches, such as interfering with osmotic pressure, triggering biocatalysis, activating immune pathways, and generating the prooxidant effect. Therefore, varieties of new strategies based on the above approaches have been studied and applied for anti-cancer applications. Moreover, many contrast agents based on metal ions have gradually become the core components of the bioimaging technologies, such as MRI, CT, and fluorescence imaging, which exhibit guiding significance for cancer diagnosis. Besides, the new nano-theranostic platforms based on metal ions have experimentally shown efficient response to endogenous and exogenous stimuli, which realizes simultaneous cancer therapy and diagnosis through a more controlled nano-system. However, most metal-based agents have still been in the early stages, and controlled clinical trials are necessary to confirm or not the current expectations. This article will focus on these new explorations based on metal ions, hoping to provide some theoretical support for more anti-cancer ideas.

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“…The abundance of polyunsaturated fatty acids greatly affected intracellular lipid peroxidation [ 69 ]. However, the substrate of lipid peroxidation is usually endogenous [ 70 ].…”

Section: New Approaches To Metal Ions-induced Cell Death and Their An...mentioning

confidence: 99%

New anti-cancer explorations based on metal ions

et al. 2022

J Nanobiotechnol

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show abstract

“…However, in the sHIE+ group six received breast milk, two received formula milk and only two were nil-by-mouth, whereas in the sHIE- group four were nil-by-mouth, three received expressed breast milk, one donor human milk, and none received formula milk. The observed increases in LA levels may therefore be a consequence of this nutritional intake, as formula milk, expressed breast milk and donor human milk are dietary sources high in LA, and low in DHA and ARA ( 36 , 37 ). High LA intake decreases DHA biosynthesis and the incorporation of DHA into tissues ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Long-chain omega-3 polyunsaturated fatty acids are reduced in neonates with substantial brain injury undergoing therapeutic hypothermia after hypoxic–ischemic encephalopathy

Dyall,

Nessel,

Sharpe

et al. 2023

Front. Neurol.

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Hypoxic–ischemic encephalopathy (HIE) is a major cause of neonatal morbidity and mortality. Although therapeutic hypothermia is an effective treatment, substantial chronic neurological impairment often persists. The long-chain omega-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, offer therapeutic potential in the post-acute phase. To understand how PUFAs are affected by HIE and therapeutic hypothermia we quantified for the first time the effects of HIE and therapeutic hypothermia on blood PUFA levels and lipid peroxidation. In a cross-sectional approach, blood samples from newborns with moderate to severe HIE, who underwent therapeutic hypothermia (sHIE group) were compared to samples from newborns with mild HIE, who did not receive therapeutic hypothermia, and controls. The sHIE group was stratified into cerebral MRI predictive of good (n = 10), or poor outcomes (n = 10; nine developed cerebral palsy). Cell pellets were analyzed for fatty acid content, and plasma for lipid peroxidation products, thiobarbituric acid reactive substances and 4-hydroxy-2-nonenal. Omega-3 Index (% DHA + EPA) was similar between control and HIE groups; however, with therapeutic hypothermia there were significantly lower levels in poor vs. good prognosis sHIE groups. Estimated Δ-6 desaturase activity was significantly lower in sHIE compared to mild HIE and control groups, and linoleic acid significantly increased in the sHIE group with good prognosis. Reduced long-chain omega-3 PUFAs was associated with poor outcome after HIE and therapeutic hypothermia, potentially due to decreased biosynthesis and tissue incorporation. We speculate a potential role for long-chain omega-3 PUFA interventions in addition to existing treatments to improve neurologic outcomes in sHIE.

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Effects of storage practices on long‐chain polyunsaturated fatty acids and lipid peroxidation of preterm formula milk

Cited by 2 publications

References 27 publications

New anti-cancer explorations based on metal ions

New anti-cancer explorations based on metal ions

Long-chain omega-3 polyunsaturated fatty acids are reduced in neonates with substantial brain injury undergoing therapeutic hypothermia after hypoxic–ischemic encephalopathy

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