Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease

Yugeta, Akihiro; Terao, Yasuo; Fukuda, Hideki; Hikosaka, Okihide; Yokochi, Fusako; Okiyama, Ryoichi; Taniguchi, Makoto; Takahashi, Hiroshi G.; Hamada, Ikuma; Hanajima, Ritsuko; Ugawa, Yoshikazu

doi:10.1212/wnl.0b013e3181d31e0b

Cited by 75 publications

(86 citation statements)

References 37 publications

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“…64 Several studies have examined the effect of STN stimulation on saccades. Stimulation of the STN reduced reflexive saccadic latencies, 3,65 increased the amplitude, 66,67 and produced a marked improvement in the gain of MGS. 68 There is also a single case report of a similar improvement in MGS, as well as antisaccades, in a patient with a GPi electrode when the stimulator is turned on.…”

Section: Response To Treatmentmentioning

confidence: 93%

Ocular motor abnormalities in neurodegenerative disorders

Antoniades

Kennard

2014

Eye

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Eye movements are a source of valuable information to both clinicians and scientists as abnormalities of them frequently act as clues to the localization of a disease process. Classically, they are divided into two main types: those that hold the gaze, keeping images steady on the retina (vestibulo-ocular and optokinetic reflexes) and those that shift gaze and redirect the line of sight to a new object of interest (saccades, vergence, and smooth pursuit). Here we will review some of the major ocular motor abnormalities present in neurodegenerative disorders.

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Section: Response To Treatmentmentioning

confidence: 93%

Ocular motor abnormalities in neurodegenerative disorders

Antoniades

Kennard

2014

Eye

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“…There were 7 women and 13 men, aged 59.5 Ϯ 7.2 years (mean Ϯ SD; range, 48 -75) with disease duration of 13.5 Ϯ 5.5 (range, 6 -24) years. Their levodopa equivalent dose was 1456.5 Ϯ 879.2 mg (range, 213-3792; for calculation, see Tomlinson et al, 2010). All of the patients self-reported being right handed.…”

Section: Methodsmentioning

confidence: 99%

“…Onset of saccades was detected using EOG. Saccades with latencies of Ͻ60 ms were considered anticipatory ( Kalesnykas and Hallett, 1987;Braun and Breitmeyer, 1988;Fischer and Weber, 1992;Weber et al, 1993;Reuter-Lorenz et al, 1995;Delinte et al, 2002). Error trials include trials with directional errors, anticipation saccades, delayed onset of saccade after 1000 ms from cue onset, and those without saccades and all were excluded from the analysis.…”

Section: Methodsmentioning

confidence: 99%

“…The BG also tonically inhibit the brainstem motor centers controlling innate movements, including saccades . Previous studies have documented that PD patients have delayed saccade latencies and hypometric primary saccades, often showing a series of small step-like saccades (White et al, 1983;Briand et al, 1999;Chan et al, 2005). Furthermore, antisaccades are more impaired than those of visually guided saccades in PD patients.…”

Section: Introductionmentioning

confidence: 97%

“…Beta-band oscillatory activities in sensorimotor cortices and in the BG have been observed both in nonhuman primates and in humans (Murthy and Fetz, 1992;Sanes and Donoghue, 1993;Baker et al, 1997;Donoghue et al, 1998;Levy et al, 2000;Cassidy et al, 2002;Williams et al, 2005). The betaband event-related desynchronization (␤-ERD) is considered to be involved in preparation and execution of limb movements (Kü hn et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Modulation of Beta Oscillations in the Subthalamic Nucleus with Prosaccades and Antisaccades in Parkinson's Disease

et al. 2013

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Increased oscillations in the beta band are thought to be related to motor symptoms of Parkinson's disease (PD). Previous studies haveshown that beta-band desynchronization in the subthalamic nucleus (STN) is reduced just before and during limb movements. While the STN is part of the basal ganglia (BG)-thalamocortical circuit controlling limb movements, it is also part of the BG-brainstem projection controlling saccadic eye movements. Late-stage PD patients have deficits in saccades in addition to difficulties with limb movements arising from impaired functions of the BG. We investigated saccade-related changes in beta-band (15-30 Hz) oscillatory activities in the human STN while PD patients performed visually guided prosaccades and antisaccades, the latter requiring suppression of reflexive responses and volitional initiation of saccades. We recorded local field potentials from deep brain stimulation electrodes implanted in the STN in human PD patients 1-5 d after surgery and compared prosaccades and antisaccades with these and with limb movements. Saccade-related beta-band desynchronizations were observed just before and during saccades in all subjects, suggesting that reduction of beta-band oscillatory activity in the STN is related to preparation and execution of saccades. Furthermore, beta-band desynchronizations for antisaccades started earlier, were sustained for longer periods, were of greater magnitude, and were observed more often than prosaccades. Beta-band desynchronization in the STN may reflect the additional processes associated with suppression of reflexive responses and volitional execution of saccades in the opposite direction.

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Impaired eye movements in Parkinson's disease and their relationship to top–down and bottom–up neural processing

Takahashi,

Kawamura,

Kobayashi

et al. 2024

Brain and Behavior

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IntroductionEye movement disorder in patients with Parkinson's disease (PD) is less likely to appear when observing complex images compared with simple images. However, in case of auditory stimuli, meaningful stimuli can promote PD movement. Thus, we measured visual search movements with an eye tracker to investigate whether visual search changes in PD depending on the meaningfulness of visual stimuli; additionally, we measured event‐related potentials (ERPs) to neurophysiologically examine visual information processing in PD.MethodsData from 11 patients with cognitively unimpaired PD and 10 neurologically healthy individuals (controls) were used in this study. We simultaneously measured eye tracking and ERPs during the observation of three types of images: operation, noun, and meaningless figures. We compared intergroup differences in visual search parameters, such as saccade count, fixation time, and saccade amplitude, as well as in ERPs vertex‐to‐vertex amplitudes and latency among P1, N1, P2, and N2 at the posterior regions. These ERPs reflect different stages of visual information processing and provide insights into the underlying neural mechanisms of visual search in PD.ResultsAll visual search parameters were consistently smaller in the PD group than in the control group, regardless of visual stimulus. The saccade count in the PD group was significantly lower than in the control group for operation and meaningless figures but not for noun figures. Further, P1 and N1 amplitudes—bottom–up processing—were smaller in PD group when viewing operation figures and N2 amplitudes—top–down processing—were larger in PD group when viewing operation and meaningless figures.ConclusionsPD's visual search movements may change depending on the meaningfulness of visual stimuli. Further, the abnormal visual search movements in PD may be due to insufficient bottom–up processing and excessive top–down processing.Plain Language SummaryParkinson's disease (PD) is a neurodegenerative disorder that can cause eye movement disorders. People with PD may have difficulty searching for and processing visual information. In this study, we investigated how meaningfulness affects visual search movements and visual information processing in people with PD. We measured eye movements and brain activity in response to different types of visual stimuli, including meaningful and meaningless images, and compared them to a group of healthy control participants. Our results showed that PD patients had fewer eye movements and different brain activity patterns compared to healthy controls, regardless of the meaningfulness of the visual stimuli. However, we also found that the meaningfulness of visual stimuli had an effect on visual search movements in PD patients. This suggests that meaningfulness can impact the way people with PD process visual information. Understanding these differences could help in the development of new therapies to improve visual processing in people with PD.

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Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease

Cited by 75 publications

References 37 publications

Ocular motor abnormalities in neurodegenerative disorders

Ocular motor abnormalities in neurodegenerative disorders

Modulation of Beta Oscillations in the Subthalamic Nucleus with Prosaccades and Antisaccades in Parkinson's Disease

Impaired eye movements in Parkinson's disease and their relationship to top–down and bottom–up neural processing

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