Effects of stimulation of glutamate receptors in medial septum on some immune responses in rats

Dutta, Ganesh; Goswami, Ananda Raj; Ghosh, Tusharkanti

doi:10.1016/j.brainres.2013.09.038

Cited by 8 publications

(1 citation statement)

References 25 publications

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“…Septum has been implicated in variety of behaviors like aggression, sexuality and drinking [5][6][7]. Recently a study by Dutta et al indicates that the medial septal glutamate receptors play an important role in the modulation of immune responses [8]. There are significant numbers of studies suggesting a probable role of septal nuclei in modulation of pain [9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Modulation of Pain by Naloxone and a Possible Role of Neurotransmitters with Selective Lesion of Septal Nuclei

Somade¹,

Brid²

2015

J Spine

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Septum occupies a strategic position in limbic system and has been implicated in variety of behaviors. Present study was designed to evaluate the role of medial septum in modulation of pain and explore the role of neurotransmitters.The present study was divided in two parts in first part the tail flick latencies were observed in rats with septal lesions and compared with sham operated ones. While in the second part, the effect of intraseptal injections of neurotransmitters and naloxone on tail flick latencies ofcannulated rats was recorded after intraseptal lesions.It was observed that the septal lesions decrease pain threshold. The interaseptal injection of Acetylcholine (5 µg to 20 µg) and Naloxone (5 µg to 20 µg) increases pain threshold. While the Interaseptal injection of Noradrenaline and Scopolamine decreases pain threshold.The findings of the present study suggest that septum may be involved in modulation of pain. The neurotransmitters like Acetylcholine, Noradrenaline and opioid peptides may have an individual or collective role to play in the observed pain modulation.

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Section: Introductionmentioning

confidence: 99%

Modulation of Pain by Naloxone and a Possible Role of Neurotransmitters with Selective Lesion of Septal Nuclei

Somade¹,

Brid²

2015

J Spine

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Medial Septal NMDA Glutamate Receptors are Involved in Modulation of Blood Natural Killer Cell Activity in Rats

Podlacha

Glac

Listowska

et al. 2015

J Neuroimmune Pharmacol

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The purpose of the present study was to determine the specific role of the medial septal (MS) NMDA glutamate receptors on peripheral blood natural killer cell cytotoxicity (NKCC) and their (large granular lymphocyte, LGL) number, as well as the plasma concentration of tumor necrosis factor α (TNF-α) and corticosterone in male Wistar rats exposed to elevated plus maze (EPM) stress or non-stress conditions. The NMDA groups were injected with NMDA glutamate receptor agonist (N-methyl-D-aspartate; 0.25 μg/rat), the D-AP7 group was injected with DL-2-amino-7-phosphoheptanoate (0.1 μg/rat), an antagonist of NMDA glutamate receptors, and the control Sal group with saline (0.5 μl/rat) via previously implanted cannulae into the MS. There was an increase in the NKCC, NK/LGL number and plasma TNF-α concentration after the NMDA injections, being much stronger within the rats under non-stress conditions rather than the rats exposed to EPM stress. These parameters were decreased in the D-AP7 rats, suggesting receptor/ion channel specificity. Moreover, a lower plasma corticosterone concentration within the NMDA rather than the Sal and D-AP7 groups was found. The obtained results suggest that activation of the NMDA glutamate receptors in the MS, accompanied by changes in the corticosterone and cytokine responses, may be involved in modulation of the blood natural anti-tumor response, under EPM stress and non-stress conditions.

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Protective effects of black tea-TV 25 on the cognitive impairments and some peripheral immune responses in intracerebroventricular colchicine injected rats

Sil

Bhandari

Gupta

et al. 2018

Orient Pharm Exp Med

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Effects of stimulation of glutamate receptors in medial septum on some immune responses in rats

Cited by 8 publications

References 25 publications

Modulation of Pain by Naloxone and a Possible Role of Neurotransmitters with Selective Lesion of Septal Nuclei

Modulation of Pain by Naloxone and a Possible Role of Neurotransmitters with Selective Lesion of Septal Nuclei

Medial Septal NMDA Glutamate Receptors are Involved in Modulation of Blood Natural Killer Cell Activity in Rats

Protective effects of black tea-TV 25 on the cognitive impairments and some peripheral immune responses in intracerebroventricular colchicine injected rats

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