Effects of Steroid Pharmaceuticals on Plasma Zinc

Briggs, Maxine; Austin, J.

doi:10.1038/232480a0

Cited by 50 publications

(14 citation statements)

References 4 publications

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“…High dose, parenteral steroids had previously been reported to lower plasma zinc (7), whereas short-term oral doses of 5 -1 0 mg of prednisolone had shown no effect on plasma zinc in another study (5). Among the adult Crohn's patients in the present series, 13 were taking oral steroids and 7 were not taking steroids at the time of the study.…”

Section: Plasma Zincmentioning

confidence: 59%

Zinc Deficiency in Crohn’s Disease

Solomons¹,

Rosenberg²,

Sandstead³

et al. 1977

Digestion

128

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Zinc nutriture has been studied in 30 patients with Crohn’s disease using plasma zinc, hair zinc, and taste acuity as indices. Significant reductions in plasma zinc concentrations and taste acuity were seen in the patient groups as compared with normal controls. Hair zinc content was also generally low with several deficient values encountered among the Crohn’s patients. A highly significant correlation between plasma zinc and albumin suggests a possible role of plasma-binding alterations in the depressed plasma zinc levels of patients with Crohn’s disease patients and a potential influence on growth and healing in this disease must be considered.

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Section: Plasma Zincmentioning

confidence: 59%

Zinc Deficiency in Crohn’s Disease

Solomons¹,

Rosenberg²,

Sandstead³

et al. 1977

Digestion

128

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“…It is well known that serum or plasma zinc levels are higher in men than in women and that they are lower in women using oral contraceptives compared with women not using birth control pills (5,22,23). This may be explained by the induction of hepatic metallothionein synthesis by the female sex steroids, particularly the estrogens (24,25).…”

Section: Discussionmentioning

confidence: 97%

Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

Thijs¹,

Staessen²,

Améry³

et al. 1992

Environ Health Perspect

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This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 1977 participants (959 men and 1018 women), 20-80 years old, constituted a stratified random sample of the population of four Belgian districts, representing two areas with low and two with high environmental exposure to cadmium. For each exposure level, a rural and an urban area were selected. The serum concentration of zinc, frequently used as an index for zinc status in human subjects, was higher in men (13.1 ,umole/L, range 6.5-23.0 ,umole/L) than in women (12.6 Rmole/L, range 6.3-23.2 Rmole/L).In men, 20% of the variance of serum zinc was explained by age (linear and squared term, R = 0.29), diurnal variation (r = 0.29), and total cholesterol (r = 0.16). After adjustment for these covariates, a negative relationship was observed between serum zinc and both blood (r = -0.10) and urinary cadmium (r = -0.14). In women, 11% of the variance could be explained by age (linear and squared term, R = 0.15), diurnal variation in serum zinc (r = 0.27), creatinine clearance (r = -0.11), log y-glutamyltranspeptidase (r = 0.08), cholesterol (r = 0.07), contraceptive pill intake (r = -0.07), and log serum ferritin (r = 0.06). Before and after adjustment for significant covariates, serum zinc was, on average, lowest in the two districts where the body burden of cadmium, as assessed by urinary cadmium excretion, was highest. These results were not altered when subjects exposed to heavy metals at work were excluded from analysis.

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“…(24) have observed the reduction of plasma radioactive zinc after the administration of histidine. Moreover, the ingestion of alcohol (27), contraceptive hormones (19,25), tetracyclines (18) all diminish the plasma zinc levels after oral administration of zinc salts. Conversely, it has been shown that zinc reduces the absorption of tetracyclines.…”

Section: Discussionmentioning

confidence: 99%

The bioavailability and pharmacokinetics of three zinc salts: Zinc pantothenate, zinc sulfate and zinc orotate

Andermann¹,

Dietz²

1982

European Journal of Drug Metabolism and Pharmacokinetics

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In this study the authors compared the pharmacokinetics of three zinc salts after parenteral and oral administration to rabbits: zinc sulfate, a soluble mineral salt; zinc pantothenate, a soluble organic salt; and zinc orotate, an insoluble organic salt. The results obtained with the two soluble salts were not significantly different (p less than 0.05). Therefore they appear to be bioequivalent. The plasma concentration curve for zinc orotate shows a faster distribution (alpha) and elimination phase (beta) after parenteral administration, and a slower absorption phase (Ka) after oral administration, when compared with that of the other two salts. It was shown that the dissolution behaviour of these zinc salts in water does not correlate with the parameters found in vivo.

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Effects of Steroid Pharmaceuticals on Plasma Zinc

Cited by 50 publications

References 4 publications

Zinc Deficiency in Crohn’s Disease

Zinc Deficiency in Crohn’s Disease

Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

The bioavailability and pharmacokinetics of three zinc salts: Zinc pantothenate, zinc sulfate and zinc orotate

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