The bioavailability and pharmacokinetics of three zinc salts: Zinc pantothenate, zinc sulfate and zinc orotate

Abstract

In this study the authors compared the pharmacokinetics of three zinc salts after parenteral and oral administration to rabbits: zinc sulfate, a soluble mineral salt; zinc pantothenate, a soluble organic salt; and zinc orotate, an insoluble organic salt. The results obtained with the two soluble salts were not significantly different (p less than 0.05). Therefore they appear to be bioequivalent. The plasma concentration curve for zinc orotate shows a faster distribution (alpha) and elimination phase (beta) after parenteral administration, and a slower absorption phase (Ka) after oral administration, when compared with that of the other two salts. It was shown that the dissolution behaviour of these zinc salts in water does not correlate with the parameters found in vivo.

Orotic acid salts as sources of orotic acid and various minerals added for nutritional purposes to food supplements

“…This is, however, not reflected in the recommended doses and has not been documented by any of the petitioners. Furthermore, studies on the bioavailability of zinc from zinc orotate, compared with other sources, clearly show that there is no marked difference between the bioavailability from the various sources (Windisch et al, 2003 andAndermann et al, 1982). Two of the petitioners extrapolate that to be the case for the other salts as well.…”

“…The bioavailability and pharmacokinetics of three zinc salts (zinc pantothenate, zinc sulphate and zinc orotate) was also evaluated in rabbits (Andermann et al, 1982). The purpose of this work was to study the pharmacokinetics and bioavailability of the three zinc salts in relation to their water solubility.…”

In vitro Study of the Antiseborrheic Activity of Zinc L-Cysteate, a Novel Zinc Compound, on Rat Preputial Gland

“…Acexamic acid is itself a topical wound-heal ing agent. Actually, when inorganic (sulfate) or organic (gluconate, acetate, pantothenate) Zn salts are used in the treatment of skin dis eases or during wound healing, only Zn ions are efficacious, even though the different bioavailabilities of the salts [31] may be an important factor [32,33].…”

Pharmacokinetics of Intravascularly Administered 65Zinc in Channel Catfish (Ictalurus punctatus)

“…Previous studies have reported either relatively short (a few weeks) or long (several months) half-lives of zinc in both mammals and "sh, depending on the test species and experimental design (Rubini et al, 1961;Shulman et al, 1961;Andermann and Dietz, 1982;Alsop et al, 1999). For example, whole-body measurements of the half-life of Zn in small "sh range from 13 days in silversides Menidia menidia (Shulman et al, 1961) to greater than 6 months in mosquito"sh Gambusia holbrooki ( formerly, G. a.nis) (Willis and Jones, 1977;Newman and Mitz, 1988).…”