Effects of statin therapy on augmentation index as a measure of arterial stiffness: A systematic review and meta-analysis

Sahebkar, Amirhossein; Pećin, Ivan; Tedeschi-Reiner, Eugenia; Derosa, Giuseppe; Maffioli, Pamela; Reiner, Željko

doi:10.1016/j.ijcard.2016.03.010

Cited by 55 publications

(38 citation statements)

References 54 publications

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“…Studies have noted that the use of ACEIs or statins has a beneficial effect on the aortic AIx value, which is independent of BP reduction or LDL-C changes. 31 , 32 The results of this study did not demonstrate a correlation between antihypertensive drugs, statins, or fibrates used with the aortic AIx values in patients with CAD. Finally, current smoking 33 and smoking pack years 34 may affect aortic AIx values.…”

Section: Limitationscontrasting

confidence: 51%

Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease

Fu¹,

Wang²,

Lee³

et al. 2018

TCRM

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PurposeAngiopoietin-like protein 3 (ANGPTL3) plays an important role in lipid metabolism and angiogenesis and is elevated in familial hypercholesterolemia, metabolic syndrome, and insulin resistance. This study aims to evaluate the relationship between the fasting serum ANGPTL3 levels and the aortic augmentation index (AIx) in patients with coronary artery disease (CAD).Materials and methodsFasting blood samples were obtained from 100 patients with CAD. The AIx was measured using a validated tonometry system (SphygmoCor). The serum ANGPTL3 levels were assessed using a commercial enzyme-linked immunosorbent assay kit.ResultsThe aortic AIx values were higher in female patients with CAD (P=0.003) than those in male patients with CAD. The univariate linear analysis of the aortic AIx values reveals that the height (r=−0.363; P<0.001) and body weight (r=−0.350; P<0.001) were negatively correlated, whereas the age (r=0.202; P=0.044) and logarithmically transformed ANGPTL3 (log-ANGPTL3, r=0.357; P<0.001) were positively correlated with the aortic AIx values in patients with CAD. The multivariate forward stepwise linear regression analysis of the factors significantly associated with the aortic AIx revealed that the height (β=−0.269; adjusted R2 change=0.123; P=0.007) and serum log-ANGPTL3 level (β=0.259; adjusted R2 change=0.051; P=0.010) were independent predictors of the aortic AIx values in patients with CAD.ConclusionThe fasting serum ANGPTL3 level positively correlated with the aortic AIx values among patients with CAD.

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Section: Limitationscontrasting

confidence: 51%

Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease

Fu¹,

Wang²,

Lee³

et al. 2018

TCRM

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“…It is also possible that extensive pharmacological treatment of our cohort for heart failure and dyslipidemia may have resulted in pre‐CRT improvement of vascular endothelial function. Statins, for instance, are known to cause a reduction in aortic AI X, 22 Angiotensin‐converting enzyme inhibitors (ACE‐I) also significantly reduce AI X ,23 and 91% of our cohort were receiving ACE‐I or angiotensin receptor blocker. It is also possible, given the observation of a (non‐significant) 20% improvement on vascular responsiveness to salbutamol and GTN post‐CRT, that a small improvement in these parameters might have been obscured via type II error.…”

Section: Discussionmentioning

confidence: 95%

Does cardiac resynchronization therapy restore peripheral circulatory homeostasis?

et al. 2017

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AimsTo evaluate whether peripheral circulatory ‘remodelling’ as measured by changes in vascular compliance and in markers of nitric oxide signalling contributes to patient response to cardiac resynchronization therapy (CRT).Methods and resultsEffects of CRT were evaluated in 33 patients pre‐procedure and 6 months post‐procedure. Peak oxygen consumption, 6 min walk distance, New York Heart Association class, and quality of life score were evaluated. Augmentation index and its interactions with nitric oxide (NO) were evaluated by applanation tonometry. Platelet NO responsiveness and content of thioredoxin‐interacting protein were assessed. Plasma concentrations of N‐terminal proBNP, asymmetric and symmetric dimethylarginine (SDMA), high sensitivity C‐reactive protein, catecholamines, and matrix metalloproteinases‐2 and ‐9 were assessed. Despite significant improvement in 6 min walk distance (P = 0.005), New York Heart Association class (P < 0.001), quality of life (P = 0.001), and all echocardiographic parameters post‐CRT, there were no significant changes in augmentation index measurements, thioredoxin‐interacting protein content, and platelet NO response. Significant falls in N‐terminal proBNP (P = 0.008) and SDMA (P = 0.013; independent of renal function) occurred. Falls in SDMA predicted reduction in high‐sensitivity C‐reactive protein (P = 0.04) and increases in peak oxygen consumption (P = 0.04). There were no correlations between changes in echocardiographic parameters and those in vascular function.ConclusionsThese data suggest that the beneficial effects of CRT over 6 months are independent of any change in peripheral NO‐related signalling. However, there is evidence that suppression of inflammation occurs, and its magnitude predicts extent of clinical improvement.

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“…In our study of kidney transplant recipients, the TG level was positively associated with the aortic AIx in simple linear regression analysis and body height was negatively associated with the aortic AIx in forward stepwise linear regression. A recent systematic review and meta-analysis showed the significant positive effects of statins in reducing the aortic AIx and improving arterial stiffness [ 24 ]. In the present study, higher AIx values were noted in the statin treatment group in renal transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

Hyperleptinemia is associated with the aortic augmentation index in kidney transplant recipients

Chen

Lee

et al. 2018

Tzu Chi Med J

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Objective:Increased circulating leptin, a marker of leptin resistance, is common in patients with obesity and is also an independent factor in prediction of cardiovascular disease. The aim of this study was to evaluate the relationship between fasting serum leptin levels and the aortic augmentation index (AIx) in kidney transplant recipients.Materials and Methods:Fasting blood samples were obtained from 70 kidney transplant recipients. The aortic AIx was measured using a validated tonometry system (SphygmoCor). Plasma leptin levels were measured using a commercial enzyme-linked immunosorbent assay kit.Results:Simple linear analysis of the aortic AIx in kidney transplant recipients showed that body fat mass (P = 0.002), diastolic blood pressure (DBP) (P = 0.020), logarithmically transformed triglycerides (P = 0.035), and leptin (P < 0.001) were positively correlated, while height (P = 0.004) and the glomerular filtration rate (P = 0.022) were negatively correlated with the aortic AIx in kidney transplant recipients. Forward stepwise linear regression analysis of the factors significantly associated with the aortic AIx showed that leptin (P < 0.001), DBP (P = 0.014), and body height (P = 0.036) were independent predictors of the aortic AIx in kidney transplant recipients.Conclusion:These results suggest that the serum fasting leptin level is associated with the aortic AIx in kidney transplant recipients.

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Effects of statin therapy on augmentation index as a measure of arterial stiffness: A systematic review and meta-analysis

Cited by 55 publications

References 54 publications

Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease

Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease

Does cardiac resynchronization therapy restore peripheral circulatory homeostasis?

Hyperleptinemia is associated with the aortic augmentation index in kidney transplant recipients

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