Hyperleptinemia is associated with the aortic augmentation index in kidney transplant recipients

Objectives: Myostatin is a myokine predominantly expressed and secreted in skeletal muscle in response to stimulations, including oxidative stress or inflammation. We investigated a potential association between myostatin levels and endothelial function among kidney transplantation (KT) patients. Materials and Methods: Fasting blood samples were collected from 64 KT patients. The endothelial function that indicated by vascular reactivity index (VRI) was measured by digital thermal monitoring test. Serum myostatin levels were measured using a commercial enzyme-linked immunosorbent assay kit. All patients were categorized into three groups according to their VRI values: poor vascular reactivity was considered if VRI <1.0; 1.0 ≤VRI <2.0 indicated intermediate vascular reactivity, and VRI ≥2.0 was grouped as good vascular reactivity. Results: Seven KT patients (10.9%) were categorized as poor vascular reactivity, 24 KT patients (37.5%) were grouped as intermediate vascular reactivity, and 33 KT patients had good vascular reactivity. Advanced age ( r = −0.372, P = 0.002) and serum alkaline phosphate (ALP) level ( r = −0.341, P = 0.006) were negatively correlated with VRI. However, serum myostatin level ( r = 0.430, P < 0.001) was positively correlated with VRI. In multivariable forward stepwise linear regression analysis, high serum level of myostatin (β = 0.441, adjusted R 2 change = 0.171; P < 0.001), advanced age (β = −0.317, adjusted R 2 change = 0.138; P = 0.003), and serum ALP level (β = −0.270, adjusted R 2 change = 0.060; P = 0.011) were significantly associated with VRI in KT patients. Conclusion: Our study showed that fasting myostatin level was positively associated with VRI and endothelial function among KT patients.

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Serum myostatin level is a positive predictor of endothelial function measured by digital thermal monitoring of vascular reactivity in kidney transplantation patients

Hsu

Lee

Lin

et al. 2022

Tzu Chi Medical Journal

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The serum sclerostin level is positively associated with the aortic augmentation index in patients on peritoneal dialysis

et al. 2019

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Objective: Sclerostin is a canonical Wingless (Wnt)/β-catenin signaling pathway inhibitor and had been associated with high arterial stiffness in patients with chronic kidney disease. The aortic augmentation index (AIx), a noninvasive method of assessing central hemodynamics/wave reflections, has been widely used as a clinical index of arterial stiffness. The aim of this study was to evaluate the relationship between fasting serum sclerostin levels and AIx values in peritoneal dialysis (PD) patients. Materials and Methods: Fasting blood samples were obtained from 75 PD patients. The aortic AIx value was measured using a validated tonometry system (SphygmoCor, AtCor Medical, Sydney, New South Wales, Australia). Serum sclerostin and dickkopf-1 (DKK1) levels were quantified using commercial enzyme-linked immunosorbent assay kits. Results: Women PD patients had higher aortic AIx values than men ( P = 0.039), while lower aortic AIx values were found in PD patients who used statins ( P = 0.004). Univariate linear analysis of the aortic AIx values in PD patients showed that systolic blood pressure ( P = 0.001), diastolic blood pressure ( P = 0.018), and serum sclerostin levels ( P = 0.001) were positively correlated, while height ( P = 0.018), body weight ( P = 0.001), body mass index ( P = 0.043), and weekly total creatinine clearance ( P = 0.015) were negatively correlated with aortic AIx values in PD patients. Multivariate linear regression analysis of the factors significantly associated with the aortic AIx values showed that serum sclerostin levels (adjusted R 2 = 0.057, P = 0.011) and systolic blood pressure (adjusted R 2 = 0.125, P = 0.004) were positively associated, while body weight (adjusted R 2 = 0.113, P = 0.002) was inversely associated with aortic AIx values in PD patients. Conclusion: In this study, the serum sclerostin level, but not DKK1, was positively associated with aortic AIx values in PD patients.

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Hyperleptinemia is associated with the aortic augmentation index in kidney transplant recipients

Cited by 2 publications

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Serum myostatin level is a positive predictor of endothelial function measured by digital thermal monitoring of vascular reactivity in kidney transplantation patients

Serum myostatin level is a positive predictor of endothelial function measured by digital thermal monitoring of vascular reactivity in kidney transplantation patients

The serum sclerostin level is positively associated with the aortic augmentation index in patients on peritoneal dialysis

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