Effects of statherin on the biological properties of titanium metals subjected to different surface modification

Lu, Xiong Gang; Xiong, Shibing; Chen, Yangmei; Zhao, Fenghua; Hu, Yi; Guo, Yuhua; Wu, Boyao; Huang, Ping; Yang, Bangcheng

doi:10.1016/j.colsurfb.2020.110783

Cited by 12 publications

(10 citation statements)

References 44 publications

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“…Implant surface modification is one of the most novel and productive research fields acquiring relevance in the search for a system that meets the ideal functional and biological goals [ 5 , 6 ]. Surface topography plays a crucial role in osseointegration and it is known that cell response can be modulated by adapting implant surface texture.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

López-Valverde

Flores-Fraile

Ramı́rez

et al. 2020

JCM

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Animal studies and the scarce clinical trials available that have been conducted suggest that bioactive surfaces on dental implants could improve the osseointegration of such implants. The purpose of this systematic review was to compare the effectiveness of osseointegration of titanium (Ti) dental implants using bioactive surfaces with that of Ti implants using conventional surfaces such as sandblasted large-grit acid-etched (SLA) or similar surfaces. Applying the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, the MEDLINE, PubMed Central and Web of Science databases were searched for scientific articles in April 2020. The keywords used were “dental implants”, “bioactive surfaces”, “biofunctionalized surfaces”, and “osseointegration”, according to the question: “Do bioactive dental implant surfaces have greater osseointegration capacity compared with conventional implant surfaces?” Risk of bias was assessed using the Cochrane Collaboration tool. 128 studies were identified, of which only 30 met the inclusion criteria: 3 clinical trials and 27 animal studies. The average STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) and ARRIVE (Animal Research: Reporting of In Vivo Experiments) scores were 15.13 ± 2.08 and 17.7±1.4, respectively. Implant stability quotient (ISQ) was reported in 3 studies; removal torque test (RTT)—in 1 study; intraoral periapical X-ray and microcomputed tomography radiological evaluation (RE)—in 4 studies; shear force (SF)—in 1 study; bone-to-implant contact (BIC)—in 12 studies; and BIC and bone area (BA) jointly—in 5 studies. All animal studies reported better bone-to-implant contact surface for bioactive surfaces as compared to control implants with a statistical significance of p < 0.05. Regarding the bioactive surfaces investigated, the best results were yielded by the one where mechanical and chemical treatment methods of the Ti surfaces were combined. Hydroxyapatite (HA) and calcium–phosphate (Ca–Ph) were the most frequently used bioactive surfaces. According to the results of this systematic review, certain bioactive surfaces have a positive effect on osseointegration, although certain coating biomolecules seem to influence early peri-implant bone formation. Further and more in-depth research in this field is required to reduce the time needed for osseointegration of dental implants.

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Section: Introductionmentioning

confidence: 99%

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

López-Valverde

Flores-Fraile

Ramı́rez

et al. 2020

JCM

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“…The water contact angle of the pure PLA scaffold was high, at more than 90° ( Figure 3 C), likely due to PLA lacking hydrophilic groups in its structure, resulting in a strong hydrophobicity on the material's surface ( Shuai et al., 2019a ). The water contact angle of the composite scaffold with the addition of nHA was significantly reduced, mainly attributed to the polar nature of HA with strong hydrophilic characteristics and the large number of active functional hydroxyl groups on its surface ( Lu et al., 2020 ). Due to the enhanced intermolecular forces, such as van der Waals, nHA often agglomerates and forms micron-sized particles ( Zhou et al., 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Improvement of the mechanical properties and osteogenic activity of 3D-printed polylactic acid porous scaffolds by nano-hydroxyapatite and nano-magnesium oxide

Cheng

et al. 2022

Heliyon

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“…Therefore, in the present study, we explored the activities of osteoblasts on the surface of different bioactive titanium implants under normoxic and hypoxic conditions. Currently, sandblasting and acid etching (SLA) is one of the most widely used non-coating surface treatment methods (Corvino et al, 2020;Lu et al, 2020). SLA combines the advantages of physical and chemical etching, while also offering an inexpensive and simple platform (Lu et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Currently, sandblasting and acid etching (SLA) is one of the most widely used non-coating surface treatment methods ( Corvino et al, 2020 ; Lu et al, 2020 ). SLA combines the advantages of physical and chemical etching, while also offering an inexpensive and simple platform ( Lu et al, 2020 ). In our study, irregular honeycomb-shaped holes were formed on the surface of the titanium plate following SLA.…”

Section: Discussionmentioning

confidence: 99%

Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium

Wang

Zhang

et al. 2021

Front. Physiol.

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Nowadays, the bone osseointegration in different environments is comparable, but the mechanism is unclear. This study aimed to investigate the osseointegration of different bioactive titanium surfaces under normoxic or high-altitude hypoxic environments. Titanium implants were subjected to one of two surface treatments: (1) sanding, blasting, and acid etching to obtain a rough surface, or (2) extensive polishing to obtain a smooth surface. Changes in the morphology, proliferation, and protein expression of osteoblasts on the rough and smooth surfaces were examined, and bone formation was studied through western blotting and animal-based experiments. Our findings found that a hypoxic environment and rough titanium implant surface promoted the osteogenic differentiation of osteoblasts and activated the JAK1/STAT1/HIF-1α pathway in vitro. The animal study revealed that following implant insertion in tibia of rabbit, bone repair at high altitudes was slower than that at low altitudes (i.e., in plains) after 2weeks; however, bone formation did not differ significantly after 4weeks. The results of our study showed that: (1) The altitude hypoxia environment would affect the early osseointegration of titanium implants while titanium implants with rough surfaces can mitigate the effects of this hypoxic environment on osseointegration, (2) the mechanism may be related to the activation of JAK1/STAT1/HIF-1α pathway, and (3) our results suggest the osteogenesis of titanium implants, such as oral implants, is closely related to the oxygen environment. Clinical doctors, especially dentists, should pay attention to the influence of hypoxia on early osseointegration in patients with high altitude. For example, it is better to choose an implant system with rough implant surface in the oral cavity of patients with tooth loss at high altitude.

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Effects of statherin on the biological properties of titanium metals subjected to different surface modification

Cited by 12 publications

References 44 publications

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

Improvement of the mechanical properties and osteogenic activity of 3D-printed polylactic acid porous scaffolds by nano-hydroxyapatite and nano-magnesium oxide

Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium

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