Effects of Sri Lankan Black Tea (<i>Camellia sinensis</i> L.) on Pregnancy of Rats

Ratnasooriya, W.D.; Fernando, T. S. P.

doi:10.1111/j.1742-7843.2008.00345.x

Cited by 10 publications

(9 citation statements)

References 11 publications

(16 reference statements)

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“…Black tea brew, which naturally contains caffeine, has been demonstrated to produce no risk in terms of pregnancy outcome in rats (Ratnasooriya et al 2009). No adverse effects have been noted even upon treatment with high doses corresponding to the consumption of 24 cups/day in humans.…”

Section: Combined Exposurementioning

confidence: 99%

The effects of prenatal exposure to methylxanthines

Skopiński

Woronkowicz²,

Skopińska-Różewska³

et al. 2011

Polish Journal of Veterinary Sciences

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This review discusses epidemiology and laboratory studies on the effects of prenatal methylxanthine administration on some systems developing organisms. They are mainly absorbed from coffee, tea and cocoa products such as cola beverages and chocolate bars.Prenatal methylxanthine exposure can induce several unfavourables changes in the developing organism, which are persistent even in later phases of life. Based on results obtained from animal studies, the effect on embryogenesis is not only poorly understood but also controversial. It is therefore important to study interspecies differences as results may differ depending on animals used and administration methods.

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Section: Combined Exposurementioning

confidence: 99%

The effects of prenatal exposure to methylxanthines

Skopiński

Woronkowicz²,

Skopińska-Różewska³

et al. 2011

Polish Journal of Veterinary Sciences

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“…Many research studies have shown that caffeine readily crosses the placenta causing teratogenic and embryotoxic effects [6,7,8]. Also shown are the adverse effects of high doses of caffeine ingested during pregnancy, both for the mother and the developing foetus [9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

The influence of caffeine administered at 10°C on bone tissue development

Tomaszewski¹,

Olchowik²,

Tomaszewska³

et al. 2016

Ann Agric Environ Med.

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Introduction and objective. Caffeine is a natural methylxanthine widespread throughout the food industry. Many research studies have shown that caffeine readily crosses the placenta causing teratogenic and embryotoxic effects. The objective of this study was to assess the influence of caffeine, administered at 10°C, on the development of a rat's bone tissue, with particular reference to elemental bone composition using an X-ray microprobe. Materials and methods. The research was conducted on white rats of the Wistar strain. The fertilized females were divided into two groups: an Experimental Group (Group E) and a Control Group (Group C). The females in Group E were given caffeine orally (at 10°C) in 30 mg/day doses from the 8 th-21 st day of pregnancy. The females in Group C were given water at the same temperature. The foetuses were used to assess the growth and mineralization of the skeleton. Qualitative analysis of the morphology and mineralization of bones was conducted using the alcian-alizarin method. For calcium and potassium analysis, an X-ray microprobe was used. Results. By staining the skeleton using the alcian-alizarin method, changes in 47 Group E foetuses were observed. The frequency of the development variants in the Group E rats was statistically higher, compared with Group C. Conclusions. On the basis of these results, it can be concluded that caffeine in high doses disturbs the development of bone tissue. An additional factor which enhances the adverse effects of this substance on bone tissue is the temperature of the administered solution (10 o C). In the Experimental Group, a significant decrease in the calcium level, as well as an increase in the potassium level, was observed. The X-ray microprobe can be a perfect complement to the methods which enable determination of the mineralization of osseous tissue.

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“…Since then, a number of studies have confirmed the negative effect of high doses of caffeine ingested during pregnancy both for the mother and the developing foetus [2,3,7,15,16,18,22,25,27,30,31].…”

Section: Introductionmentioning

confidence: 99%

The temperature of caffeine administered during pregnancy and foetal morphometric parameters

et al. 2014

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Background: Caffeine is one of the most frequently ingested (at various tempe- Materials and methods: The research was conducted on rats. The fertilised females were randomly divided into two main groups: an experimental (E) and a control group (C). The experimental groups received caffeine (30 mg/day) in 10 (E1), 25 (E2) and 45°C (E3). The females in the control group were given water at the same temperature (C 1 , C 2 and C 3 ). On the 21 st day of pregnancy, the pregnant females were killed by decapitation using a specially prepared laboratory guillotine and were assessed morphometric parameters of foetuses.Results and Conclusions: Based on this work showed that: the embryotoxic effect of caffeine was only confined to a reduction in the number of offspring; the greatest changes in the morphometric parameters occurred in foetuses whose mothers received caffeine at 10°C; in the control groups, the greatest changes were observed in foetuses whose mothers were given water at 10°C during pregnancy. (Folia Morphol 2014; 72, 3: 347-352)

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Effects of Sri Lankan Black Tea (Camellia sinensis L.) on Pregnancy of Rats

Cited by 10 publications

References 11 publications

The effects of prenatal exposure to methylxanthines

The effects of prenatal exposure to methylxanthines

The influence of caffeine administered at 10°C on bone tissue development

The temperature of caffeine administered during pregnancy and foetal morphometric parameters

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