Effects of spirulina on weight loss and blood lipids: a review

DiNicolantonio, James J.; Bhat, Anusha Ganapati; O’Keefe, James H.

doi:10.1136/openhrt-2018-001003

Cited by 45 publications

(31 citation statements)

References 37 publications

(59 reference statements)

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“…Treatment with spirulina along that showed decreases significantly in serum of LDL,Cholest and Trigly when comparative with group adenine . The HDL level significantly increase when comparative with group adenine .in this study reported with other study (Bhat et al,2020). The hypo-lipaemic ability of spirulina was also reported in mice with alloxan-induced diabetes represented by reduce triacylglycerol and LDL as well as increase in HDL levels 37 .…”

Section: Resultssupporting

confidence: 83%

Antioxidant Activity of Spirulina Powder in Male Rate with Adenine–Induced Chronic Renal Failure

Yonis¹,

Hassan²

2020

MLU

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The present study aimed evaluate the role of spirulina in reduction the ability of adenine induction renal failure and its complication in male rates. Twenty four adult male rats used in the present study and divided into four groups, first group consider as control group, the second group received adenine (100 mg/kg) intraperitoneal, while the third group receive mixed with feed and adenine (100 mg/kg) intraperitoneal combined with spirulina powder (750 mg/kg) and the fourth group receive just spirulina powder (750 mg/kg) also with feed, the result showed experiment blood was collected to assessment kidney function for (KIM-1, Ureaandcreatinine), lipid profile function test for (cholesterol, triglyceride, LDL and HDL). parameter of antioxidant concentration for (SOD,GSH,MAD and ON).in the present study when treated by adenine group that showed increases KIM, Urea and creatinine. the lipid profile results showed significance increase (p≤0.05) in Cholesterol,TG and LDL in the second group which administrated adenine while HDL was decreased in the same group. . the results showed significance (p≤0.05) decrease in the GSH, SOD and increase in the MAD and No in the second group. Spirulina powder showed significance enhancement in the most of parameters which studied to return near to the control group.

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Section: Resultssupporting

confidence: 83%

Antioxidant Activity of Spirulina Powder in Male Rate with Adenine–Induced Chronic Renal Failure

Yonis¹,

Hassan²

2020

MLU

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“…Moreover, spirulina has some potential anti‐appetite agents like amino acids, polyunsaturated fatty acids, and other micronutrients. Indeed, there is evidence reporting the beneficial role of spirulina on the progression of obesity and anthropometric indices (DiNicolantonio, Bhat, & OKeefe, 2020). Therefore, the aim of the current study was to examine the studies on effectiveness of spirulina supplementation on obesity indices, by performing a systematic review and meta‐analysis of randomized controlled trials ( RCTs).…”

Section: Introductionmentioning

confidence: 99%

Spirulina supplementation and anthropometric indices: A systematic review and meta‐analysis of controlled clinical trials

Zarezadeh

Faghfouri

Radkhah

et al. 2020

Phytotherapy Research

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Obesity and overweight are associated with the burden of chronic diseases. The aim of the present meta‐analysis is to determine the efficacy of spirulina in reducing of obesity indices. PubMed, Web of Science, Scopus, EMBASE and Cochrane library databases were searched up to November 2019. Randomized controlled trials comparing spirulina supplementation with a placebo or no treatment for anthropometric indices were included. Meta‐analysis was performed using random‐effects model. Subgroup analysis and meta‐regression were carried out. Publication bias was evaluated using standard methods. Spirulina had ameliorative effects on weight (WMD = −1.85 Kg; 95% CI: −2.44, −1.26; p < .001; I2 = 82.4%, p < .001), and waist circumference (WMD = −1.09 cm; 95% CI: −2.16, −0.01; p = .046; I2 = 0.0%, p = .757) while no significant effect was shown on body mass index, even after sensitivity analysis (SMD = −0.53 Kg/m2; 95% CI: −1.25, 0.19; p = .149; I2 = 92.9%, p < .001); however, spirulina was effective in studies lasted for at least 12 weeks (SMD = −1.25 Kg/m2; 95% CI: −2.21, −0.28; p = .011; I2 = 90.8%, p < .001). Spirulina supplementation exerts beneficial effects on weight and waist circumference. The ameliorative effect of spirulina on body mass index was revealed in longer duration of supplementation.

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“…This study supported the anti-obesity effect of Spirulina noticed in the present study. The proposed anti-obesity mechanisms of action of Spirulina are macrophage infiltration reduction into visceral fat, combating hepatic fat accumulation, reduction in oxidative stress, improvement in insulin sensitivity and satiety (DiNicolantonio et al, 2020). Spirulina was also found to render fat digestion and absorption in the small intestine (Han et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Spirulina as Anti-Obesity and Hepato-Renal Protective Agent in MSG -Exposed Female Rats

El-Hashash

2021

Alexandria Science Exchange Journal

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High intake of monosodium glutamate (MSG)containing foods was reported as a major health problem in Egypt. Thus, dietary interventions aim to prevent the deleterious effects of this additive were badly needed. This study was carried out to investigate the effect of concurrent consumption of MSG and Spirulina (S. platensis) on body weight as well as hepato-renal functions and histopathology in female rats. Twenty adult female albino rats were divided into four equal groups, including the control group, while groups 2 to 4 were administered 6 mg MSG/kg body weight daily, and kept untreated (group 2), or concurrently fed pelleted balanced diet supplemented with 0.5 and 1 % of Spirulina powder for 6 weeks (groups 3 and 4, respectively). At the end, body weight gain, feed intake and feed efficiency ratio were calculated. Liver and kidney functions were determined in sera, while oxidative stress markers were determined in liver and kidney tissue homogenates. Moreover, specimens from liver and kidney of sacrificed rats were histopathologically examined. On the other hand, phenolic profile of Spirulina powder was identified and quantified by HPLC. Findings indicated that MSG consumption resulted in overweight, liver and kidney dysfunction along with oxidative stress, which was further confirmed by histological staining. Due to the high content of phenolic compounds rather than other antioxidant agents, Spirulina powder exerted anti-obesity properties and alleviated the toxic hepato-renal effects caused by MSG consumption. So, dietary supplementation of MSG -containing food products with Spirulina powder is recommended to prevent its accompanied health abnormalities.

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Effects of spirulina on weight loss and blood lipids: a review

Cited by 45 publications

References 37 publications

Antioxidant Activity of Spirulina Powder in Male Rate with Adenine–Induced Chronic Renal Failure

Antioxidant Activity of Spirulina Powder in Male Rate with Adenine–Induced Chronic Renal Failure

Spirulina supplementation and anthropometric indices: A systematic review and meta‐analysis of controlled clinical trials

Spirulina as Anti-Obesity and Hepato-Renal Protective Agent in MSG -Exposed Female Rats

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