Antioxidant Activity of Spirulina Powder in Male Rate with Adenine–Induced Chronic Renal Failure

Abstract

The present study aimed evaluate the role of spirulina in reduction the ability of adenine induction renal failure and its complication in male rates. Twenty four adult male rats used in the present study and divided into four groups, first group consider as control group, the second group received adenine (100 mg/kg) intraperitoneal, while the third group receive mixed with feed and adenine (100 mg/kg) intraperitoneal combined with spirulina powder (750 mg/kg) and the fourth group receive just spirulina powder (750 mg/kg) also with feed, the result showed experiment blood was collected to assessment kidney function for (KIM-1, Ureaandcreatinine), lipid profile function test for (cholesterol, triglyceride, LDL and HDL). parameter of antioxidant concentration for (SOD,GSH,MAD and ON).in the present study when treated by adenine group that showed increases KIM, Urea and creatinine. the lipid profile results showed significance increase (p≤0.05) in Cholesterol,TG and LDL in the second group which administrated adenine while HDL was decreased in the same group. . the results showed significance (p≤0.05) decrease in the GSH, SOD and increase in the MAD and No in the second group. Spirulina powder showed significance enhancement in the most of parameters which studied to return near to the control group.