Effects of soybean peptide on immune function, brain function, and neurochemistry in healthy volunteers

Yimit, Dilshat; Hoxur, Parida; Amat, Nurmuhammat; Uchikawa, Kimono; Yamaguchi, Nobuo

doi:10.1016/j.nut.2011.05.008

Cited by 64 publications

(31 citation statements)

References 55 publications

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“…Amino acid analysis showed that the amino acids compositions in SP and FSP were similar. Asparagine and glutamic acid were major amino acids in both SP and FSP (Dilshat, Parida, Nurmuhammat, Kimono, & Nobuo, 2012;Liu, Lv, Xu, & Guo, 2016). In this study, the contents of isoleucine, leucine, methionine, and valine in FSP were increased by 34.74%, 47.31%, 109.80%, and 30.4%, respectively, compared to SP (Table 3).…”

Section: Amino Acids Composition Of Peptides In Fsbmmentioning

confidence: 48%

Peptides derived from fermented soybean meal suppresses intestinal inflammation and enhances epithelial barrier function in piglets

Chen

Zong

Shi

et al. 2019

Food and Agricultural Immunology

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This study was to investigate the effects of peptides derived from fermented soybean meal (FSP) on intestinal inflammation and epithelial barrier function of the piglets. Compared to fed soybean meal, piglets fed with fermented soybean meal (FSBM) exhibit lower serum levels of IL-6, IL-1β and D-lactate, and reduced ileum macrophage infiltration. Besides, the FSBM upregulated (p < 0.05) expression of mucins and tight junction (TJ) proteins in the jejunum and ileum of piglets. The FSP were prepared with alkali extraction and a 3-kDa molecular weight cut-off membrane system. In vitro, FSP reducing the mRNA expression of IL-6, IL-1β, IL-8 and attenuated Escherichia coli K88induced inflammation in the intestinal porcine epithelial cells-J2 (IPEC-J2). Furthermore, FSP increased (p < 0.05) the expression of TJ proteins and transepithelial electrical resistance in IPEC-J2 cells. These results suggest that FSP could improve small intestinal health by enhancing epithelial barrier function and suppressing inflammation.

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Section: Amino Acids Composition Of Peptides In Fsbmmentioning

confidence: 48%

Peptides derived from fermented soybean meal suppresses intestinal inflammation and enhances epithelial barrier function in piglets

Chen

Zong

Shi

et al. 2019

Food and Agricultural Immunology

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“…Oil obtained from soybeans is very rich in essential fatty acids like linoleic and linolenic acids. Both are very important for human health, as they help regulate blood pressure and facilitate the absorption of vital nutrients [8]. Soybean contains isoflavones that minimizes the risk of developing certain cancers, particularly, genistein-an isoflavone that has extensive antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

Proximate Composition, Phytoconstituents and Mineral Contents of Soybean (Glycine Max) Flour Grown and Processed in Northern Nigeria

Uwem¹,

Babafemi²,

Sunday³

2017

AAS

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Soybean (Glycine max), is a species of legume widely grown for its edible bean which has numerous uses.Soybeans are an important source of not only proteins, but carbohydrates, fats, and many essential vitamins and minerals. So, they facilitate normal growth and development in young children. In this study, the phytoconstituents, proximate composition and mineral contents of soybean flour was evaluated using standard processing techniques. The preliminary phytochemical screening indicated the presence of phenols, cardiac glycosides, steroids, saponins, flavonoids in both the methanol and aqueous extracts. The quantitative phytochemical screening showed that saponin had the highest content (18.4%) followed by phenol (16.8%) and flavonoids (12.4%) while phytate was the least (0.07%). The proximate composition was in this order: protein >carbohydrate > crude fat > moisture > crude fibre > ash content which showed that the soy flour is relatively high in protein. The minerals analyzed for were: Ca (231.6), Fe (5.790), Mg (249.8), Zn (2.414) and Mn (0.651) which were within the FAO/WHO standards for metals in foods.

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“…Evidence suggests that soybean oil may also convey neuroprotective effects. Soybean oil is a natural source of isoflavone phytoestrogens, and previous animal studies have demonstrated that estrogens can have antioxidant effects in the brain and can modulate neurotransmitters (Yaman et al, 2007;Yimit et al, 2012). Indeed, after estrogen treatment in experimental TBI, blood levels of glutamate are reduced, and brain activity of the antioxidant superoxide dismutase is increased (Shahrokhi et al, 2012;Zlotnik et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Effect of fish oil supplementation in a rat model of multiple mild traumatic brain injuries

Wang

Van

Gavitt

et al. 2013

Restorative Neurology and Neuroscience

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Purpose: Repetitive mild traumatic brain injury (TBI) is a major military and sports health concern. The purpose of this study was to determine if a diet rich in omega-3 fatty acids would reduce cognitive deficits and neuronal cell death in a novel fluid percussion rat model of repetitive mild TBIs. Methods: Thirty-two Sprague-Dawley rats were assigned to either an experimental rat chow enhanced with 6% fish oil (source of omega-3 fatty acids) or a control rat chow. Both rat chows contained equivalent quantities of calories, oil, and nutrients. After four weeks, both groups received mild repetitive bilateral fluid percussion TBIs on two sequential days. Pre-injury diets were resumed, and the animals were monitored for two weeks. On post-injury days 10-14, Morris Water Maze testing was performed to assess spatial learning and cognitive function. Animals were euthanized at 14 days post-injury to obtain specimens for neurohistopathology. Results: There was no difference in pre-injury weight gain between groups. Post-injury, animals on the fish oil diet lost less weight and recovered their weight significantly faster. By 14 days, the fish oil diet group performed significantly better in the Morris Water Maze. Neurohistopathology identified a non-significant trend toward a higher density of hippocampal neurons in the fish oil diet group. Conclusions: Pre-injury dietary supplementation with fish oil improves recovery of body weight and provides a small improvement in cognitive performance in a rat model of multiple mild TBIs.

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Effects of soybean peptide on immune function, brain function, and neurochemistry in healthy volunteers

Cited by 64 publications

References 55 publications

Peptides derived from fermented soybean meal suppresses intestinal inflammation and enhances epithelial barrier function in piglets

Peptides derived from fermented soybean meal suppresses intestinal inflammation and enhances epithelial barrier function in piglets

Proximate Composition, Phytoconstituents and Mineral Contents of Soybean (Glycine Max) Flour Grown and Processed in Northern Nigeria

Effect of fish oil supplementation in a rat model of multiple mild traumatic brain injuries

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