Effects of soybean isoflavones, probiotics, and their interactions on lipid metabolism and endocrine system in an animal model of obesity and diabetes

Ali, Aidy; Velasquez, Manuel T.; Hansen, Carl T.; Mohamed, Ali I.; Bhathena, Sam J.

doi:10.1016/j.jnutbio.2004.04.005

Cited by 110 publications

(80 citation statements)

References 62 publications

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“…a,b,c Values within column with different superscript letters are significantly different (P<0.05). in agreement with the reports of several studies [42,43]. In the present study, the level of plasma TAGs was significantly (P<0.05) reduced in rats fed with LaVK2 Dahi when compared to Dahi or BM.…”

Section: Abcsupporting

confidence: 94%

Probiotic LaVK2 Dahi Improves Lipid Profiles in Hypercholesterolemic Rats

Kumar¹,

Sagwal²,

Kružliak³

2015

J Adv Dairy Res

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Background: There is a growing interest concerning the role of probiotics as natural hypocholesterolemic agents in etiopathogenesis of cardiovascular and related heart diseases. Based on the growing evidence of the importance of probiotics with potential cardiovascular benefits, the efforts to improve the lipid profile using lactic acid bacteria in an optimal direction are gathering momentum. Methods:The effects of probiotic Dahi containing L. acidophilus LaVK2 and Dahi culture on lipid profiles in rats with diet-induced hypercholesterolemia were studied. Three treatment groups of rats (n=7) were fed experimental diets: LaVK2 Dahi, Dahi or buffalo milk (BM) for 120 days. After the consumption of experimental diets, animals were fed a hypercholesterolemic diet ad libitum.Results: Supplementation with LaVK2 Dahi decreased plasma total cholesterol by 22.6%; however, in BM and Dahi fed groups, the increase was over 70%. The decrease in triacylglycerol level in rats fed LaVK2 Dahi was 64.2%. Plasma high density lipoprotein (HDL) increased by 72.6% in LaVK2 Dahi fed group, whereas low density lipoprotein (LDL) + very low density lipoprotein (VLDL)-cholesterol decreased by 89%, respectively. As a result, the atherogenic index (AI), the ratio of HDL to LDL+VLDL was decreased by 91.2% on LaVK2 Dahi when compared to only 13.1% decline on BM. Futhermore, the accumulations of total cholesterol and triacylglycerols in liver and aortic tissues were significantly (P<0.05) reduced in rats fed with LaVK2 Dahi. Conclusion:These observations suggest that oral administration of probiotic LaVK2 Dahi attenuated dietinduced hypercholesterolemia leading to cardiac protection by decreasing VLDL+LDL-cholesterol, LDL-cholesterol and TAGs and increasing HDL-cholesterol. Probiotic LaVK2 Dahi may have a therapeutic potential to improve the lipid profile and the risk of cardiovascular diseases.

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Section: Abcsupporting

confidence: 94%

Probiotic LaVK2 Dahi Improves Lipid Profiles in Hypercholesterolemic Rats

Kumar¹,

Sagwal²,

Kružliak³

2015

J Adv Dairy Res

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“…Contrary to this, other authors did not observe any effect, neither on the cholesterol level nor on the fatty acid profile, when animals and humans were supplemented with probiotics [24][25][26][27].…”

Section: Introductioncontrasting

confidence: 63%

Modification of the fat composition of the Iberian pig using Bacillus licheniformis and Bacillus subtilis

Parra¹,

Petrón²,

Martín³

et al. 2010

Euro J Lipid Sci & Tech

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The aim of this work was to study the influence of a diet with probiotic bacteria on the lipid composition of different tissues from Iberian pigs. Cholesterol and fatty acid profiles were measured in liver, subcutaneous fat, and Serratus ventralis muscle samples. Feeding Iberian pigs a mixture of probiotic microorganisms for 45 days prior to slaughter affected the tissue composition. The feeds of the control and probiotic groups were identical except for the added Bacillus licheniformis and Bacillus subtilis (1.28 × 109 cfu/kg feed) in the feed of the probiotic group. The diet with probiotics significantly affected the fatty acid profile of liver, subcutaneous fat and Serratus ventralis muscle samples, but no significant differences were found for the cholesterol content. The livers of the probiotic group contained lower levels of n‐6 fatty acids and higher levels of n‐3 fatty acids. The subcutaneous fat contained lower levels of n‐6 fatty acids. Serratus ventralis muscles from the probiotic group contained a significantly higher percentage of oleic acid than those of the control group.Practical applications: This study deals with the effect of the addition of probiotic bacteria to the diet of pigs on both the cholesterol and fatty acid content. B. subtilis and B. licheniformis can be used in pig feed (Regulation EC no. 2148/2004), but there are no studies about their effects on fresh meat or other tissues, particularly regarding the fat composition. Thus, it is interesting to study how feeding these microorganisms affects the different tissues. Including these microorganisms in the basic diet could serve as a strategy to modify the fat composition and to obtain healthier products from pigs.

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“…While our results showed that soy flour and oat bran have no effect on the lipid profile of rats, Madani et al (2004) reported no difference in CHOL and TG and a decrease in LDL in rats that consumed soy in comparison with casein (both with cholesterol in the diet), after 2 months of the diet. Ali et al (2004) showed that isoflavones also reduce total as well as LDL and HDL cholesterol in rats. However, in many studies, a small increase in HDL cholesterol is observed after feeding soybean or isoflavones alone, whereas in others either no change or a small decrease in HDL cholesterol is observed (MASILAMANI; WEI; SAMPSON, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…Soy protein components, such as isoflavones, have well-known chemopreventive and anti-inflammatory activities (MASILAMANI; WEI; SAMPSON, 2012). Furthermore, although soluble fibres and soy protein also have hypercholesterolaemic activities (ALI et al, 2004;DENG, 2009;TONG et al, 2015), the mechanisms by which they lower blood cholesterol and lipid levels have not yet been explained. The cholesterol-lowering activities of dietary fibre and soy protein have been associated with β-glucan and isoflavones, respectively (ALI et al, 2004;DENG, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, although soluble fibres and soy protein also have hypercholesterolaemic activities (ALI et al, 2004;DENG, 2009;TONG et al, 2015), the mechanisms by which they lower blood cholesterol and lipid levels have not yet been explained. The cholesterol-lowering activities of dietary fibre and soy protein have been associated with β-glucan and isoflavones, respectively (ALI et al, 2004;DENG, 2009). Active compounds are normally ingested inside a food matrix and their properties are influenced by the interaction with other components and processing.…”

Section: Introductionmentioning

confidence: 99%

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The effects of oat bran and soy flour on humoral immune response in rats fed hypercholesterolaemic diets

Lobato¹,

Fernandes²,

Juliani³

et al. 2017

Semin. Cienc. Biol. Saude

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Estudos anteriores têm demonstrado os efeitos sobre o sistema imune e sobre os níveis de colesterol da dieta com fibra solúvel e proteína de soja em ratos. Nesse estudo, nós avaliamos os efeitos do farelo de aveia e da farinha de soja na resposta imune humoral de ratos Wistar tratados com dietas hipercolesterolêmicas. Os animais (6 grupos) foram alimentados com diferentes dietas por 6 semanas e inoculados duas vezes com antígeno (IgY). As amostras de plasma foram coletadas após cada inoculação e os níveis de anticorpos anti-IgY (IgM, IgG1 e IgG2a) foram avaliados por ELISA. Os animais que receberam 1% de colesterol apresentaram um aumento de IgG1 anti-IgY e uma redução de IgM e IgG2a anti-IgY em relação aos animais controle. Estes efeitos foram anulados em animais alimentados com ARTIGOS / ARTICLES CIÊNCIAS BIOLÓGICAS E DA SAÚDEPrevious studies have demonstrated the immunological and hypercholesterolaemic effects of soluble dietary fibre and soy protein in rats. In this study, we evaluated the effects of oat bran and soy flour on humoral immune response in Wistar rats fed hypercholesterolaemic diets. Animals (6 groups) fed with different diets for 6 wks were inoculated twice with antigen (IgY). Plasma samples were collected after each inoculation and anti-IgY antibody (IgM, IgG1 and IgG2a) levels were evaluated by ELISA. Animals receiving 1% cholesterol presented an increase in anti-IgY IgG1 and a reduction in anti-IgY IgM and IgG2a relative to control animals. These effects were abrogated in animals fed 1% cholesterol and oat bran or oat bran+soy protein, but not in animals fed 1% cholesterol and soy protein. Diets containing 1% cholesterol resulted in hepatic lesions and higher liver and spleen relative weights, but did not affect lipid profile, weight gain, food intake, or food conversion efficiency. In conclusion, a high-cholesterol diet influences classes of antibodies produced in response to an antigen in a way that can be reversed by oat bran. Resumo

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Effects of soybean isoflavones, probiotics, and their interactions on lipid metabolism and endocrine system in an animal model of obesity and diabetes

Cited by 110 publications

References 62 publications

Probiotic LaVK2 Dahi Improves Lipid Profiles in Hypercholesterolemic Rats

Probiotic LaVK2 Dahi Improves Lipid Profiles in Hypercholesterolemic Rats

Modification of the fat composition of the Iberian pig using Bacillus licheniformis and Bacillus subtilis

The effects of oat bran and soy flour on humoral immune response in rats fed hypercholesterolaemic diets

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