Effects of Soy Protein Diet on the Expression of Adipose Genes and Plasma Adiponectin

Abstract

Many studies have reported the cholesterol-lowering, anti-lipogenic, anti-obesity and anti-hypertensive effects of soy protein. Adipose tissue-specific plasma protein, adiponectin, has anti-atherogenic and anti-insulin-resistance properties. Here, we investigated the effects of soy protein diet on body fat composition, plasma glucose, lipid and adiponectin levels and expression of genes involved in glucose and fatty acid metabolism in obese KK-A y mice. Body weights and adipose tissue weights of mesenteric, epididymal, and brown fat were lower in mice on calorie-restricted diet containing soy protein isolate. Plasma cholesterol, triglyceride, free fatty acid, and glucose levels were also decreased by this diet. Body fat content and plasma glucose levels in mice on a soy protein isolate diet were still lower than those treated with an isocaloric casein-protein-diet. Among the genes related to glucose and fatty acid metabolism, adiponectin mRNA levels in adipose tissue and adiponectin plasma concentrations were elevated in mice on a calorie-restricted diet, although there were no significant differences between soy protein and casein protein groups. Our results indicate that that soy protein diet decreased body fat content and plasma glucose levels more effectively than isocaloric casein-protein diet in obese mice.

Epicardial adipose tissue expression of adiponectin is lower in patients with hypertension

“…In animal models, adiponectin infusion has beneficial effects concerning the metabolic syndrome, insulin sensitivity and cardiovascular function. In humans, different factors can cause hyperadiponectinaemia and hence its beneficial effects: weight loss, 37 diet factors (soy protein, oils) 38 and drugs, such as thiazolidinediones, 30 angiotensin converter enzyme inhibitors 39 or angiotensin receptor blockers. 40 In our sample, prescription of the latter two groups of drugs was in total almost 10% higher in hypertensive patients.…”

O tratamento com isoflavonas mimetiza a ação do estradiol no acúmulo de gordura em ratas ovariectomizadas

“…Esses resultados são semelhantes a dados da literatura, que relacionam o uso de ISO com menor acúmulo de tecido adiposo branco, indicando efeito antilipogênico (43)(44)(45)(46).…”

β-Conglycinin Lowers Very-Low-Density Lipoprotein-Triglyceride Levels by Increasing Adiponectin and Insulin Sensitivity in Rats

“…[11][12][13] In a recent report, Nagasawa et al reported that SPI intake decreased blood glucose in diabetic kk-Ay mice. 14) Recently, Samoto et al found that 11S globulin (glycinin), lipophilic protein (LP), and 7S globulin (-conglycinin) are the major protein components of SPI. 15) They reported that the ratio of -conglycinin in SPI is 23%.…”