O tratamento com isoflavonas mimetiza a ação do estradiol no acúmulo de gordura em ratas ovariectomizadas

Abstract

RESUMOObjetivo: As isofl avonas (ISO) presentes na soja são consideradas fi toestrógenos. A administração de fi toestrógenos tem efeito benéfi co nos distúrbios da pós-menopausa que são caracterizados pela suspensão da função ovariana com declínio da secreção de estrogênio e conseqüentes desajustes histomorfológicos e metabóli-cos. O objetivo do presente estudo foi investigar o efeito da suplementação com ISO sobre a espessura do endométrio uterino, o acúmulo de gordura tecidual, o colesterol HDL e a glicose plasmática de ratas ovariectomizadas (OVX ABSTRACT Treatment with Isofl avones Replaces Estradiol Effect on the Tissue Fat Accumulation from Ovariectomized Rats.Objective: Isofl avones (ISO) present in soybean are named phytoestrogens because they show estrogen effect. The use of isofl avones has benefi cial effect in disturbance of post-menopause, which is characterized by ovarian function suppression. Decreasing of estrogen secretion and consequent morphologic and metabolic disarrangements are observed in female hormonal decline. The aim of present work was to investigate the effect of ISO on the fat accretion of uterin endometric tissue, and HDL and glucose blood concentration from ovariectomized rats (OVX). Methods: Female Wistar rats with 60 days-old were submitted a surgery to remove bilaterally the ovarium. After 8-day recovery period the animals were distributed into three groups: sham operate (GC); OVX ISO untreated (GI) and OVX supplemented with ISO (G II). Total uterus mass, uterus fat and retroperitoneal fat pad, were removed, washed and weighted. Samples of uterus were histological processed to measure endometrium thickness. Blood samples were also collected to analyze the concentration of HDL and glucose. The OVX caused endometric atrophy, decrease of uterus weight and HDL reduction. The treatment with ISO provoked decrease of uterin and retroperitoneal fat pad. HDL increase and glycemia reduction were also observed. However, there was no uterotrophic effect. Conclusions: ISO treatment causes decrease in tissue fat accretion from ovariectomized rats. (Arq Bras Endocrinol Metab 2008; 52/9:1489-1496)

Protection of estrogen in portal hypertension gastropathy: an experimental model

“…Torrezan et al (36) demonstrated that ovariectomy decreases the weight of uterine horns, a fact that was confirmed in our study, comparing the efficacy of surgery as well as evidencing the absence of circulating estrogen (Figure 1).…”

“…Thus, after the process of castration there is a decrease in serum E2 as well as a reduction of the weight of uterine horns (36) . In cells, E2 can inhibit apoptosis of endothelial cells and promotes angiogenic activity in vitro (15) .…”

Autonomic activity and glycemic homeostasis are maintained by precocious and low intensity training exercises in MSG-programmed obese mice

“…Plasmas obtained were stored in freezer for posterior analyses of glucose by the glucoseoxidize method [68] and for insulin concentration by radioimmunoassay [69].…”

Influência da proteína de soja e dos exercícios com pesos sobre o gasto energético de repouso de mulheres na pós-menopausa

“…In addition to protein, soy stands out among the legumes due to its high content of phytoestrogens, including isoflavones 16 , which have been investigated (among other reasons) for their stimulating effect on production of thyroxine, a potent mediator of energy metabolism 38 . Isoflavones also appear to assist in reducing body fat by decreasing lipogenesis and increasing lipolysis 39 , which contributes to a proportional increase in muscle mass.…”