Effects of some commonly used drugs on cognitive functions

Currently, cognitive impairment is a determining factor in the decline in adaptation in the elderly. Damage to the cerebral vessels is one of the most common causes of the development of cognitive deficits. Patients with severe cognitive impairments are not easily treatable, require outside help, and have significant limitations in daily activities. In most cases, this stage is preceded by a period of mild cognitive impairment. As a rule, mild cognitive impairments often remain undiagnosed, since they do not cause restrictions in daily activities for a long time and are detected only thanks to highly specific neuropsychological tests. But it is precisely the timely diagnosis and treatment of cognitive impairment without dementia, that make it possible to achieve longterm remission of the disease, to delay the onset of pronounced cognitive deficit. Among the correction methods, non-drug methods and pharmacological therapy are distinguished. Of no small importance is the impact on vascular risk factors such as arterial hypertension, diabetes mellitus, hyperlipidemia, smoking, alcohol abuse, etc. Nutrition planning, dosed exercise and cognitive training are the most common non-pharmacological strategies for correcting cognitive impairment. Pharmacological treatment includes anticholinesterase and neurometabolic drugs, as well as drugs aimed at correcting risk factors. A growing number of researchers agree that complex therapy, including lifestyle modification and the use of pharmacotherapy, is preferable. The article discusses the most commonly used methods of treating non-demented cognitive impairments, presents the results of large randomized clinical trials devoted to this problem, presents our own experience of both exclusively non-drug effects on patients and the use of complex treatment using a neurometabolic drug.

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Formation, Assessment and Correction of Cognitive Disorders in Patients With Comorbid Chronic Obstructive Pulmonary and Coronary Heart Diseases

Tokarieva

2021

IMJ

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Chronic obstructive pulmonary disease is an important health, social and economic issue. It is one of the leading morbidity and mortality causes worldwide. Comorbid pathology of chronic obstructive pulmonary and coronary heart diseases occurs quite often. For the patients over 60 years, the frequency of their combination directly depends on age due to common pathogenetic mechanisms (oxidative stress, endothelial dysfunction, systemic inflammation, etc.). Often these diseases are accompanied with cognitive disorders. Impaired memory and other cognitive functions significantly reduce the quality of life of the patients, negatively affect professional activities, reduce the ability to learn, reduce compliance with therapy, complicate psychological contact with the physician, and worsen the lives of relatives. But there is still no common clear understanding of many aspects of the development of cognitive disorders, their mechanisms in chronic obstructive pulmonary disease in combination with coronary heart disease. Therefore, there is no single standard method to treat such patients. In addition to medications (vasoactive and neurotropic drugs), alternative methods are used to treat cognitive disorders, namely these are special exercises to train memory and attention (cognitive training). Methods aimed at increasing the patient's motivation, learning effective memorization strategies, training the ability to maintain a long−term concentration, active involvement of emotional support and imagination are relevant. The use of available non−drug methods, dosed exercise and proper nutrition can reduce the severity of cognitive disorders and thereby improve the quality of life of the patients and their immediate environment. Key words: chronic obstructive pulmonary disease, coronary heart disease, comorbidity, cognitive disorders

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Effects of some commonly used drugs on cognitive functions

Cited by 3 publications

References 21 publications

Drug-induced cognitive impairment and dementia

Drug-induced cognitive impairment and dementia

Treatment of non-demented vascular cognitive disorders

Formation, Assessment and Correction of Cognitive Disorders in Patients With Comorbid Chronic Obstructive Pulmonary and Coronary Heart Diseases

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