Effects of social isolation rearing on learning in the morris water maze

Wongwitdecha, Noppamars; Marsden, C.A.

doi:10.1016/0006-8993(95)01578-7

Cited by 85 publications

(41 citation statements)

References 41 publications

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“…It is well known that the effects of MS on cognitive function are related to differences in the experimental design, animal strain, age, or other factors. Similarly, it has been reported that social isolation can induce the impairment [14] or enhancement [46] of the reversal learning ability in the MWM. Our study is the first observation that investigated the effects of long term repeated MS on reversal learning in the MWM in rats.…”

Section: Reversal Learning In the Mwmmentioning

confidence: 96%

The different effects of maternal separation on spatial learning and reversal learning in rats

Wang

et al. 2015

Behavioural Brain Research

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Section: Reversal Learning In the Mwmmentioning

confidence: 96%

The different effects of maternal separation on spatial learning and reversal learning in rats

Wang

et al. 2015

Behavioural Brain Research

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“…In addition, IR rats demonstrate neophobia Gentsch et al 1982;Hall et al 1997b), increased timidity , increased anxiety (Wright et al 1991), and perseverative behaviours Dalrymple-Alford and Benton 1984). Moreover, IR seems to affect cognitive learning in diverse tasks (Greenough et al 1972;Gardner et al 1975;Holson 1986;Weiss et al 2001), although some conflicting results exist regarding the IR effect on spatial learning tasks (Wongwitdecha and Marsden 1996; G. Gregorian, I. Weiss and J. Feldon, unpublished observations). Finally, IR does not affect LI (Feldon et al 1990;Weiss et al 2001).…”

Section: Social Isolationmentioning

confidence: 99%

Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review

2001

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Rationale: In schizophrenia research, the study of animal models has received considerable attention in the past 20 years. The value of animal models in preclinical research is widely recognised, largely because they can provide precious knowledge regarding the neurobiology of schizophrenia and can also be used for developing antipsychotic drugs. Prepulse inhibition (PPI; reduction in startle reflex induced by a prestimulus) is impaired in schizophrenic patients, a finding that has been associated with a loss of sensorimotor gating abilities. In rats, the schizophrenic-like PPI deficit can be induced by pharmacological or surgical manipulations targeting mainly the cortico-meso-limbic circuitry. Objectives: The literature was critically reviewed in an effort to determine the robustness and the relevance for schizophrenia of another category of animal models, based purely on manipulations of the social environment, that encompasses the neurodevelopmental hypothesis of schizophrenia. Specifically, we focused our attention on the long-term effects of such environmental models on sensorimotor gating processes as assessed in the PPI paradigm, with an attempt to evaluate their face, predictive and construct validity. Results: Our review of the literature leads to the conclusion that social deprivation performed directly after weaning (~21 days of age) is more likely to be a relevant model for PPI impairments in schizophrenia than pre-weaning manipulations. Conclusions: Although the robustness of such environmental models requires further study, these animal models offer the advantage of avoiding invasive manipulations, which allows for a variety of anatomical, electrophysiological, neuroendocrine or neurochemical investigations in the absence of confounding pharmacological or surgical effects.

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“…Isolation rearing is considered an animal model of chronic stress because it is an experience that is ecologically unnatural for this species (Moyer & Korn, 1965;Palanza, 2001;Sutanto & de Kloet, 1994). Thus, many studies have examined the effects of isolation on a variety of behaviors such as reactivity to a novel environment (Gentsch, Lichtsteiner, Kraeuchi, & Feer, 1982;Hall, Humby, Wilkinson, & Robbins, 1997b;Sahakian, Burdess, Luckhurst, & Trayhurn, 1982), social behavior (Brotto, Gorzalka, & Hanson, 1998;Van den Berg, van Ree, & Spruijt, 1999), and maze learning (Wade & Maier, 1986;Wongwitdecha & Marsden, 1996). Activity in a novel environment is one of the main measures used in these studies.…”

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confidence: 99%

The effects of isolation rearing on open‐field behavior in male rats depends on developmental stages

Arakawa

2003

Developmental Psychobiology

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The effects of the duration of isolation and age during isolation on open-field behavior in rats were examined. An inner wall divided the floor of the field into two areas, a peripheral alley and the center square, and the subjects' behavior in each area was measured. An increase in the tendency to avoid the center square was found in rats isolated during their juvenile stage, which disappeared if they were reared in pairs for a long period after isolation. On the other hand, subjects isolated during their postmaturity stage displayed an increased tendency to approach the center square whereas isolation during sexual maturity had no effect. The duration of isolation showed no consistent effect; rather, the effect depended on the age of the subjects during isolation. These findings suggest that isolation affects the open-field behavior of rats in various ways, depending on their age during isolation.

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Effects of social isolation rearing on learning in the morris water maze

Cited by 85 publications

References 41 publications

The different effects of maternal separation on spatial learning and reversal learning in rats

The different effects of maternal separation on spatial learning and reversal learning in rats

Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review

The effects of isolation rearing on open‐field behavior in male rats depends on developmental stages

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