Effects of smoking on thermal pain threshold in deprived and minimally-deprived habitual smokers

Pauli, Paul; Rau, Harald; Zhuang, Ping; Brody, Stuart; Birbaumer, Niels

doi:10.1007/bf02253538

Cited by 54 publications

(30 citation statements)

References 16 publications

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“…109 Second, analgesic effects of nicotine may differ across experimental pain models (table 1). Although nicotine consistently increases pain thresholds in cold pressor tests, 9,11,13,110 results are inconsistent with heat 108,111,112 or electrical stimulation pain models. 10,12,[113][114][115] Finally, the effects of nicotine may depend on sex.…”

Section: Human Studiesmentioning

confidence: 85%

“…10,12,[113][114][115] Finally, the effects of nicotine may depend on sex. Studies of male subjects find that smoking consistently produces analgesia, 9,11,13,112 whereas studies with only or mostly females report negative results. 113,116 In one study involving both sexes, transdermal nicotine increased pain thresholds to electrical stimulation in males but not females.…”

Section: Human Studiesmentioning

confidence: 89%

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Smoking and Pain

Weingarten²,

et al. 2010

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Cigarette smoke, which serves as a nicotine delivery vehicle in humans, produces profound changes in physiology. Experimental studies suggest that nicotine has analgesic properties. However, epidemiologic evidence shows that smoking is a risk factor for chronic pain. The complex relationship between smoking and pain not only is of scientific interest, but also has clinical relevance in the practice of anesthesiology and pain medicine. This review will examine current knowledge regarding how acute and chronic exposure to nicotine and cigarette smoke affects acute and chronic painful conditions. It will cover the relevant pharmacology of nicotine and other ligands at the nicotinic acetylcholine receptor as related to pain, explore the association of cigarette smoking with chronic painful conditions and potential mechanisms to explain this association, and examine clinical implications for the care of smokers with pain.

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Section: Human Studiesmentioning

confidence: 85%

Section: Human Studiesmentioning

confidence: 89%

Smoking and Pain

Weingarten²,

et al. 2010

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“…In general, smoking a cigarette increases thresholds to painful stimulation in experimental settings [88][89][90][91]. Nicotine administered to nonsmoking surgical patients shortly before emergence from anesthesia decreases pain scores and morphine utilization [92].…”

Section: Nervous System Effectsmentioning

confidence: 99%

Tobacco control for anesthesiologists

Warner

2007

J Anesth

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Anesthesiologists daily witness the consequences of tobacco use, the most common preventable cause of death. Smoking-related diseases such as atherosclerosis and chronic obstructive pulmonary disease increase anesthetic risk, and even smokers without overt disease are at increased risk for morbidity such as pulmonary and wound-related complications. Evidence suggests that stopping smoking will reduce the frequency of these complications. Nicotine and the other constituents of cigarette smoke, such as carbon monoxide, have important physiologic effects that may affect perioperative management. In addition, it is now apparent that the scheduling of elective surgery represents an excellent opportunity for smokers to quit in the long term. This review serves as an introduction to tobacco control for anesthesiologists, first examining issues of importance to perioperative management. It then discusses how anesthesiologists and other perioperative physicians can help address tobacco use, both at an individual level with their patients, and by contributing to the implementation of effective public health strategies in their countries. Anesthesiologists can play a key role in helping their patients quit smoking. Effective tobacco control measures applied to surgical patients will not only improve immediate perioperative outcomes but also long-term health.

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“…Pomerleau and colleagues have shown that smoking a nicotine-containing cigarette increased the pain awareness thresholds in the cold pressor test (Fertig et al, 1986;Pomerleau et al, 1984). Pauli et al (1993) demonstrated that cigarette smoking decreased sensitivity to thermal stimuli. Girdler et al (2005) in their recent study also observed that women smokers had greater threshold and tolerance to ischemic pain than women nonsmokers when pain testing followed rest.…”

Section: Human Studiesmentioning

confidence: 99%

Tobacco/nicotine and endogenous brain opioids

Xue

Domino

2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Smoking is a major public health problem with devastating health consequences. Although many cigarette smokers are able to quit, equal numbers of others cannot! Standard medications to assist in smoking cessation, such as nicotine replacement therapies and bupropion, are ineffective in many remaining smokers. Recent developments in the neurobiology of nicotine dependence have identified several neurotransmitter systems that may contribute to the process of smoking maintenance and relapse. These include: especially dopamine, but also norepinephrine, 5-hydroxytryptamine, acetylcholine, endogenous opioids, gamma-aminobutyric acid (GABA), glutamate, and endocannabinoids. The present review examines the limited contribution of the endogenous opioid system to the complex effects of nicotine/tobacco smoking.

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Effects of smoking on thermal pain threshold in deprived and minimally-deprived habitual smokers

Cited by 54 publications

References 16 publications

Smoking and Pain

Smoking and Pain

Tobacco control for anesthesiologists

Tobacco/nicotine and endogenous brain opioids

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