Effects of Smoking on Central Corneal Thickness and the Corneal Endothelial Cell Layer in Otherwise Healthy Subjects

İlhan, Nilüfer; İlhan, Özgür; Çoşkun, Mesut; Dağlioğlu, Mutlu Cıhan; Tuzcu, Esra Ayhan; Kahraman, Hilal; Keskın, Uğurcan

doi:10.1097/icl.0000000000000212

Cited by 21 publications

(22 citation statements)

References 37 publications

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“…Smoking is prevalent among Egyptian men much more than Egyptian women [36]. This assumption was tested by Sayin et al who revealed a lower percentage of endothelial hexagonal cells observed in smokers than nonsmokers ( P < 0.001) [37] and Ilhan et al who found decreased ED and Hex, with increased CV in smokers versus nonsmokers [38].…”

Section: Discussionmentioning

confidence: 99%

Corneal Endothelial Cell Density and Morphology in Healthy Egyptian Eyes

Abdellah

Ammar

Anbar

et al. 2019

Journal of Ophthalmology

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Purpose. To evaluate the corneal endothelial cell density and morphology in normal Egyptian eyes. Methods. In total, 568 healthy eyes of 568 Egyptian volunteers aged 20 to 85 years were examined using noncontact specular microscopy for the central corneal thickness (CCT), mean endothelial cell density (MCD), coefficient of variation (CV) in cell area, mean cell area (MCA), and hexagonal cell (Hex) percentage. Variables were compared between sexes and between different age groups. Results. The mean CCT, MCD, and MCA were 514.45 ± 43.04 μm, 2647.50 ± 382.62 cells/mm2, and 390.59 ± 149.94 μm2, respectively. MCD and MCA showed no significant differences between men and women (P=0.171 and 0.099, respectively), whereas CV (%) and Hex (%) showed significant differences (P=0.024 and 0.015, respectively). CCT (P=0.007, r = −0.113) and MCD (P<0.001, r = −0.357) exhibited a significant negative correlation with age, whereas CV (%) (P<0.001, r = 0.341) and MCA (P=0.008, r = 0.111) exhibited a significant positive correlation. The mean rate of endothelial cell loss from 20 to 85 years of age was 0.3% per year. Conclusions. Our results provide normative data for the corneal endothelium in healthy Egyptian eyes, thus increasing the knowledge base for corneal endothelial cell parameters in healthy Egyptian eyes. Furthermore, our findings can be used as baseline values for comparisons between Egyptian and other populations and for studies of the endothelial cell reserve and capacity for intraocular surgery and corneal transplantation.

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Section: Discussionmentioning

confidence: 99%

Corneal Endothelial Cell Density and Morphology in Healthy Egyptian Eyes

Abdellah

Ammar

Anbar

et al. 2019

Journal of Ophthalmology

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“…Golabchi et al reported that smoking results in an increased CV and decreased ECD (15). Ilhan et al (16) reported that smoking does not affect the CCT, CV, and percentage of hexagonality values, but there was a significant reduction in ECD in smokers. However, Kara et al (17) did not determine any significant difference between smokers and non-smokers regarding the mean ECD or parameters of endothelial cell morphology.…”

Section: Discussionmentioning

confidence: 98%

Assessment of anterior segment parameters and specular microscopy findings in patients with COPD

Taşlı¹

2020

Erciyes Med J

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Objective:The aim of the present study was to assess the anterior segment parameters of patients with chronic obstructive pulmonary disease (COPD) by corneal specular microscopy and biometry and to compare the results with healthy controls. Materials and Methods:Our prospective study consisted of 122 eyes of 61 patients with COPD and 110 eyes of 55 patients without any systemic diseases. A comprehensive medical history was obtained, and corrected visual acuity, bio microscopic and fundus examination, intraocular pressure (IOP) measurement with applanation tonometry, and non-contact specular microscopy were performed in all participants. Results:The endothelial cell density was lower in the COPD group than in the control group (p<0.001). The coefficient of variation (CV) was higher, central corneal thickness was significantly higher, and hexagonal cell ratio (HEX) was lesser in the COPD group than in the control group (p<0.001). Any significant difference between the control and the COPD groups was not determined in comparison with IOP, mean axial length keratometry (Kmean), anterior chamber depth (ACD), and white-to-white limbus length (WTW) measurements. Patients were grouped into two regarding the disease severity as mildmoderate (group 1, n=20), and moderate-severe (group 2, n=41) according to the Global Initiative for Chronic Obstructive Lung Disease criteria. The number of endothelial cells was lesser, the CV was higher, and the HEX was lower in the moderate-severe COPD group than in the mild-moderate COPD group (p<0.001). The duration of smoking was significantly longer in the moderate-severe group than in the mild-moderate COPD group (p<0.001). Conclusion:We suggest that in patients with COPD, due to the reduction of endothelial functional preserve, the risk of corneal endothelial damage is increased in intraocular surgery. In patients with end-stage COPD, caution should be exercised with regard to endothelial decompensation, frequent disease in the general population, corneal parameters, and to define the alterations that the ocular surgeons should be cautious about. Data regarding the alterations in anterior segment parameters in patients with COPD are highly limited in the previous literature.

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“…Aging, intraocular surgery, trauma, glaucoma, smoking and alcohol decrease the number of endothelial cells, and cause morphological changes in the endothelial cell layer (13)(14)(15). Endothelial cell analysis is important to evaluate corneal function and viability.…”

Section: Discussionmentioning

confidence: 99%