Effects of Smoking Intervention and the Use of an Inhaled Anticholinergic Bronchodilator on the Rate of Decline of FEV1. The Lung Health Study

Anthoisen, N. R.; Connett, John E.; Kiley, James P.; Altose, M. D.; Bailey, William C.; Buist, A. Sonia; Conway, William; Enright, P.; Kanner, Richard E.; Hara, P. O; Owens, Gregory R.; Scanlon, Paul D.; Tashkin, D.P.; Wise, Robert A.

doi:10.1097/00132586-199510000-00063

Cited by 104 publications

(135 citation statements)

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“…Rates of decline of FEV 1 This tendency has been noted in other follow-up studies of cliniwere assessed in terms of change expressed as a percentage cal trials involving smoking cessation (5), and indeed a similar of the predicted normal value, which should account for sex trend was observed during LHS 1 in that cross-sectional quit differences in stature and lung size. There was a small sex differrates in the UC group after the first year increased faster than ence among SQs favoring the women, but none among CSs, in the SI group (2). This was presumably due to the much higher apparently indicating that the effects of smoking and smoking quit rate being obtained in the SI group at the onset of LHS 1, cessation were similar for the two sexes.…”

Section: Smokers the Ordinate Rep-mentioning

confidence: 77%

“…mortality (1). Intent-to-treat analysis showed that smoking Measurements of FEV 1 and FVC were made before and at least 20 cessation reduced the rate of decline of lung function, minutes after two puffs (200 g) of albuterol from a metered dosed whereas inhaled bronchodilator did not (2).…”

mentioning

confidence: 99%

“…Results were analyzed according to the original LHS 1 treatment for assessment of pulmonary function (2). Further, at the end assignment: usual care (UC) and smoking intervention (SI).…”

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confidence: 99%

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Smoking and Lung Function of Lung Health Study Participants after 11 Years

Anthonisen

Connett²,

Murray

2002

Am J Respir Crit Care Med

599

367

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Eleven years after Lung Health Study (LHS) entry, we performed spirometry in 77.4% of surviving participants who enrolled in a long-term follow-up study. Those not enrolling tended to be younger male heavy smokers who continued to smoke during the LHS. Their initial LHS lung function, after adjustment for these factors, did not differ from that of enrollees. Smoking habits by original LHS treatment groups (smoking intervention vs. usual care) tended to converge, but 93% of participants who were abstinent throughout the LHS were still abstinent at 11 years. Differences in lung function between treatment groups persisted; smoking intervention participants had less decline in FEV(1) than usual care participants. Men who quit at the beginning of the LHS had an FEV(1) rate of decline of 30.2 ml/year, whereas women who quit declined at 21.5 ml/year. Men continuing to smoke throughout the 11 years declined by 66.1 ml/year, and women continuing to smoke declined by 54.2 ml/year. When decline in FEV(1) was expressed as a percentage of predicted normal value, no significant sex-based difference was apparent among continuing smokers. At 11 years, 38% of continuing smokers had an FEV(1) less than 60% of the predicted normal value compared with 10% of sustained quitters.

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Section: Smokers the Ordinate Rep-mentioning

confidence: 77%

mentioning

confidence: 99%

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Smoking and Lung Function of Lung Health Study Participants after 11 Years

Anthonisen

Connett²,

Murray

2002

Am J Respir Crit Care Med

599

367

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“…All the moderate-heavy smokers should also undergo spirometry because they could be more motivated to stop smoking if they realise that their respiratory problems are caused by smoking and that they are at risk of developing COPD [29]. Smoking cessation has been proven to be capable of reversing the steep decline in lung function [30] and, at present, it is the only intervention able to do so. Recent results of the Lung Health Study showed that males and females who quit smoking at the beginning of the study and were still abstaining after 11 yrs had almost halved the decline of FEV1 per year as compared to those who continued to smoke throughout the 11 yrs.…”

Section: Discussionmentioning

confidence: 99%

Chronic cough and phlegm in young adults

Cerveri¹,

Accordini²,

Corsico³

et al. 2003

Eur Respir J

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The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines underline that the presence of chronic cough and sputum production before airflow obstruction offers a unique opportunity to identify subjects at risk of chronic obstructive pulmonary disease for an early intervention. Current epidemiological data on these subjects are scant.Between 1998-2000, the authors evaluated the prevalence and characteristics of these symptoms by a multicentre cross-sectional survey of Italian people aged between 20-44 yrs from the general population (Italian Study on Asthma in Young Adults (ISAYA)). Besides the questions on asthma, more than 18,000 subjects answered the question: "Have you had cough and phlegm on most days for as much as 3 months per year and for at least two successive years?"The adjusted prevalence of subjects with chronic cough and phlegm was 11.9%, being 11.8% in males and 12.0% in females. From these subjects y20% reported coexisting asthma and y30%, predominately females, were nonsmokers. The survey showed that sex (female), smoking and low socioeconomic status were significantly and independently associated with chronic cough and phlegm, current smoking playing the major role.The prevalence of subjects with chronic cough and phlegm is startlingly high among young adults. Further follow-up studies are needed to establish how many of them will go on to develop chronic obstructive pulmonary disease. Eur Respir J 2003; 22: 413-417.

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“…Un metaanálisis de la colaboración Cochrane 26 revisó 123 ensayos aleatorizados y encontró que todas las formas de TSN son efectivas, reportando Odds Ratio (OR) resumen de 1,77 (IC 95% 1,66-1,88). En los pacientes con EPOC en el Lung Health Study, Anthonisen et al 27 , utilizaron tratamiento conductual intensivo más chicles de nicotina, con resultados favorables (22% de abstinencia a los 5 años vs 5% en grupo control) y sin efectos adversos serios.…”

Section: Terapia De Sustitución De Nicotinaunclassified