Effects of Smoking and Age on Chronic Obstructive Pulmonary Disease in Japan

Kojima, Shigeko; Sakakibara, Hiroki; Motani, Shinichi; Hirose, Katsumi; Mizuno, Fumio; Ito, Madoka; Hashimoto, Shuji

doi:10.2188/jea.15.113

Cited by 25 publications

(13 citation statements)

References 14 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1, we found that age, sex and smoking are substantial environmental risk factors of COPD phenotype and COPD-related quantitative trait (FEV1). This result agrees with the analysis performed by Kojima et al (2005), in which they showed age and smoking were strong risk factors for COPD under the standard diagnostic criteria. By analyzing the genetic risk factors of COPD phenotype, it appeared that two deleterious nsSNPs (rs1138272 and rs6712954) in BN1 (Fig.…”

Section: Construction Of Bayesian Networksupporting

confidence: 92%

A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population

Hua

et al. 2012

Genes Genet. Syst.

View full text Add to dashboard Cite

Chronic Obstructive Pulmonary Disease (COPD) is a complex human disease which is driven not only by genetic factors, but also by various environmental variables, such as gender, age and smoking. Therefore, there is a demand for investigating the complexity among various risk factors involved in COPD. In this study, 44 tagging SNPs from EPHX1, GSTP1, SERPINE2 and TGFB1 were selected and genotyped in 310 COPD cases and 203 controls, all of which belong to the Han from North China. We integrated functional prediction algorithms of nonsynonymous SNPs (nsSNPs) into Bayesian network to explore the complex regulatory relationships among disease traits and various risk factors. The results showed that three basic variables (age, sex and smoking) were risk factors of COPD-related trait and phenotype. Besides these environmental risk factors, deleterious nsSNPs were found to perform better than those of significant synonymous SNPs when used as variables to make risk prediction of disease outcome. This study provides further evidences for detecting the complexity of COPD in Northern Chinese Han Population.

show abstract

Section: Construction Of Bayesian Networksupporting

confidence: 92%

A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population

Hua

et al. 2012

Genes Genet. Syst.

View full text Add to dashboard Cite

show abstract

“…occupational exposure, respiratory disease during childhood, undernourished status and poor healthcare). Strong associations between COPD and age among nonsmokers could be attributed not only to the accumulative effects of risk factors over time, but also to the age-related weakening of respiratory muscles that leads to decreased peak expiratory flow and FEV1/FVC by standardised spirometry tests [36]. In the current study, male nonsmokers were more likely to have COPD than female nonsmokers, probably a result of higher exposure to risk factors.…”

Section: Copd In Chinese Nonsmokers Y Zhou Et Almentioning

confidence: 47%

COPD in Chinese nonsmokers

Zhou¹,

Yao²,

Chen³

et al. 2009

European Respiratory Journal

140

109

View full text Add to dashboard Cite

Little is known about chronic obstructive pulmonary disease (COPD) in Chinese nonsmokers. The present study aimed to investigate the profiles of COPD among nonsmokers based on the Chinese Epidemiological Survey of COPD (CESCOPD).In the CESCOPD, 20,245 subjects aged 40 yrs or older were interviewed with questionnaires and spirometry tests. Subjects with a post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ratio of ,0.70 were identified as having COPD. Data of 12,471 nonsmokers and 1,024 smoking COPD patients were analysed in the current study.The overall prevalence of COPD among nonsmokers was 5.2% (95% confidence interval 4.8-5.6). Being male, of advanced age, lower body mass index (BMI) and lower educational level, having exposure to environmental tobacco smoke, coal and/or biomass smoke, poor ventilation in the kitchen, a family history of respiratory disease and recurrent childhood cough were all independently associated with a higher risk of having COPD among nonsmokers. Nonsmokers with respiratory symptoms without airflow limitation showed a somewhat different pattern of risk factors. Nonsmokers with COPD were less likely to present with chronic productive coughs and lower BMI, while more likely to have received a physician diagnosis of asthma and respiratory diseases in childhood, than smokers with COPD.Chronic obstructive pulmonary disease is prevalent among Chinese nonsmokers, and nonsmoking chronic obstructive pulmonary disease may have different profiles from smoking chronic obstructive pulmonary disease.

show abstract

“…Young [69]2009MaleSpirometryNew Zealand654>40S. Kojima [70]2005Male and FemaleSpirometryJapan1146025–74S. Liu [71]2007Male and FemaleSpirometryChina3286>40T.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis approach to study the prevalence of chronic obstructive pulmonary disease among current, former and non-smokers

2015

View full text Add to dashboard Cite

Comparative risk assessment for Chronic Obstructive Pulmonary Disease (COPD) among current, former and non-smokers categories remains controversial and not studied in detail. We conducted a meta-analysis to summarize all the relevant published studies on this topic and to update the association between smoking and prevalence of COPD in current, former and non-smokers. Identification, screening, eligibility and inclusion of articles for the study were conducted as per the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Quality assessment of included studies was undertaken using a scoring sheet. Meta-analysis after the final synthesis of the selected studies was performed using the STATA and Comprehensive Meta-Analysis (CMA) software. Estimates from forty two independent studies reporting 547,391 individuals were identified. Twenty two studies were conducted in Europe, nine in America and ten in Asia and one from New Zealand. The meta-analysis showed that the prevalence of COPD was significantly higher in current smokers compared with former and non-smokers. However, owing to large heterogeneity among the estimates obtained from the studies, stratification was done with respect to continent, diagnostic criteria of COPD and study design which also showed similar results. The stratified analysis also revealed similar trend of results with prevalence of COPD being higher in current smokers as compared to former and non-smokers. The present meta-analysis highlights the positive association between smoking and COPD prevalence. There is an urgent need to implement more effective policies towards the restriction of tobacco use, to reduce the burden of COPD.

show abstract

Effects of Smoking and Age on Chronic Obstructive Pulmonary Disease in Japan

Cited by 25 publications

References 14 publications

A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population

A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population

COPD in Chinese nonsmokers

Meta-analysis approach to study the prevalence of chronic obstructive pulmonary disease among current, former and non-smokers

Contact Info

Product

Resources

About