Effects of Sleeve Gastrectomy on the Metabolic Profile and on the Expression of Renin-Angiotensin System in Adipose Tissue of Obese Rats

Crespo, Thaísa Soares; Andrade, João Marcus Oliveira; Paraíso, Alanna Fernandes; Lelis, Deborah de Farias; Chagas, Pablo Vinicyus Ferreira; Jorge, Amanda Lacerda; Ferreira, Wagner Leite; Paula, Alfredo Maurício Batista de; Guimarães, André Luiz Sena; Santos, Sérgio Henrique Sousa

doi:10.2174/0929866524666170728155926

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…Therefore, obesity-induced angiotensin excess is a cornerstone in the management of obesity-associated hypertensive disease [59]. Bariatric surgery is associated with a 70% rate of resolution of the hypertensive disease, since it improves all the mechanisms that link obesity with hypertension, including the renin-angiotensin-aldosterone system (RAAS) overactivity [61] along with sympathetic activity-dependent vasoconstriction and insulin resistance.…”

Section: Specific Adipokinesmentioning

confidence: 99%

Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

et al. 2019

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Obesity, which is a worldwide epidemic, confers increased risk for multiple serious conditions including type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular diseases. Adipose tissue is considered one of the largest endocrine organs in the body as well as an active tissue for cellular reactions and metabolic homeostasis rather than an inert tissue only for energy storage. The functional pleiotropism of adipose tissue relies on its ability to synthesize and release a large number of hormones, cytokines, extracellular matrix proteins, and growth and vasoactive factors, which are collectively called adipokines known to influence a variety of physiological and pathophysiological processes. In the obese state, excessive visceral fat accumulation causes adipose tissue dysfunctionality that strongly contributes to the onset of obesity-related comorbidities. The mechanisms underlying adipose tissue dysfunction include adipocyte hypertrophy and hyperplasia, increased inflammation, impaired extracellular matrix remodeling, and fibrosis together with an altered secretion of adipokines. This review describes the relevance of specific adipokines in the obesity-associated cardiovascular disease.

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Section: Specific Adipokinesmentioning

confidence: 99%

Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

et al. 2019

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“…In a recent study, Crespo et al [ 39 ] explored the effect of sleeve gastrectomy (SG) on the metabolic profile and on the expression of inflammatory markers and RAS components in different tissues of rats featuring diet-induced obesity. Bearing this in mind, male Wistar rats were fed with a standard or a HFD (8 or 61% of energy as fat, respectively) for two months.…”

Section: Influence Of Different Dietary Patterns and Weight-loss Strategies In Adipose Tissue Ace2 Levels Evidence From Preclinical Studimentioning

confidence: 99%

“…The influence on Ace2 of other non-dietary treatments that lead to a reduction in adipose tissue weight such as administration of angiotensin (1-7) or gastrectomy have also been reported. These have shown an increase in Ace2 gene expression in adipose tissue [ 38 , 39 ]. Although a correlation analysis between adipose tissue size and Ace2 expression has not been carried out in the aforementioned studies, the reported data cannot be used to hypothesize about the potential relationship between these two parameters.…”

Section: Influence Of Different Dietary Patterns and Weight-loss Strategies In Adipose Tissue Ace2 Levels Evidence From Preclinical Studimentioning

confidence: 99%

An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity

Gómez‐Zorita

Milton-Laskíbar

García-Arellano

et al. 2021

IJMS

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The present review is aimed at analysing the current evidence concerning the potential modulation of obesity and/or diet in adipose tissue ACE2. Additionally, the potential implications of these effects on COVID-19 are also addressed. The results published show that diet and obesity are two factors that effectively influence the expression of Ace2 gene in adipose tissue. However, the shifts in this gene do not always occur in the same direction, nor with the same intensity. Additionally, there is no consensus regarding the implications of increased adipose tissue ACE2 expression in health. Thus, while in some studies a protective role is attributed to ACE2 overexpression, other studies suggest otherwise. Similarly, there is much debate regarding the role played by ACE2 in COVID-19 in terms of degree of infection and disease outcomes. The greater risk of infection that may hypothetically derive from enhanced ACE2 expression is not clear since the functionality of the enzyme seems to be as important as the abundance. Thus, the greater abundance of ACE2 in adipose tissue of obese subjects may be counterbalanced by its lower activation. In addition, a protective role of ACE2 overexpression has also been suggested, associated with the increase in anti-inflammatory factors that it may produce.

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Adipokines in obesity and metabolic-related-diseases

et al. 2023

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Effects of Sleeve Gastrectomy on the Metabolic Profile and on the Expression of Renin-Angiotensin System in Adipose Tissue of Obese Rats

Abstract: This study showed that SG leads to weight loss and improves metabolic parameters. Changes in the expression of RAS components and of inflammatory molecules in adipose tissue seem to play a role the before beneficial effects of the SG.

Cited by 5 publications

References 36 publications

Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity

Adipokines in obesity and metabolic-related-diseases

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