Effects of site, cerebral perfusion and degree of cerebral artery stenosis on cognitive function

Xie, Binbin; Liu, Yidan; Wu, Dongmei; Li, Gongbo; Chen, Taosong; Xiao, Shengnan; Yang, Jing; Li, Jiamin; Li, Xiaofeng

doi:10.1097/wnr.0000000000001588

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Intracranial artery stenosis degree = (1 − diameter at the most stenotic point/diameter of the artery distal to the stenosis) × 100%. Classification of cerebral artery stenosis: less than 50% stenosis is mild, 50% to 69% is moderate, and more than 70% is severe [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

Correlation between Lpa, APO-A, APO-B, and Stenosis of Middle Cerebral Artery in Patients with Cerebral Ischemic Stroke

Chen

et al. 2022

Emergency Medicine International

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Ischemic stroke (CIS) is characterized by a high incidence, disability, and mortality. Numerous studies have demonstrated that intracranial arterial stenosis is an important pathological basis of CIS, and its main cause is atherosclerosis. Dyslipidemia is an important risk factor for atherosclerosis. Lysophosphatidic acid (Lpa), apolipoprotein -A(APO-A), and apolipoprotein -B(APO-B) proved to be significantly correlated with the severity of coronary artery disease. This study retrospectively collected the case data of 186 patients with CIS treated from May 2020 to May 2022 and explored the correlation between Lpa, APO-A, APO-B, and middle cerebral artery (MCA) stenosis in CIS patients.

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Section: Methodsmentioning

confidence: 99%

Correlation between Lpa, APO-A, APO-B, and Stenosis of Middle Cerebral Artery in Patients with Cerebral Ischemic Stroke

Chen

et al. 2022

Emergency Medicine International

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“…Cerebral blood flow is essential to support neurons and other cells in brain, and disruption of cerebral blood flow may facilitate the development and progression of AD and other dementia [ 46 ]. Low cerebral perfusion may impair global cognitive function, memory, psychomotor speed, frontal lobe function and executive function [ 47 ]. Schwarz et al [ 48 ] suggested that n-3PUFAs supplementation may potentially improve cerebral perfusion in patients who suffer from MCI, and thus have the potential to delay or even prevent further cognitive decline and the conversion to AD.…”

Section: Discussionmentioning

confidence: 99%

N-3 Polyunsaturated Fatty Acids in Elderly with Mild Cognitive Impairment: A Systemic Review and Meta-Analysis

Yang

Zhao

Sun

et al. 2024

JAD

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Background: Mild cognitive impairment (MCI) is the prodromal stage of dementia. In this stage, reasonable intervention measures can help to delay the decline of cognitive function. Supplementation of n-3 polyunsaturated fatty acids (n-3PUFAs) may be beneficial to delay the decline of cognitive function in the elderly. Objective: To investigate the effectiveness of docosapentaenoic acid (DHA) or/and eicosapentaenoic acid (EPA) supplements in the elderly with MCI. Methods: Eight electronic databases, PubMed, Cochrane Library, Embase, VIP, SinoMed, Web of Science, CNKI, and WANFANG DATA, were searched for related articles from inception until January 2022. Subgroup analyses and sensitivity analyses were performed to detect confounding variables. Standardized mean differences (SMD) with 95% confidence intervals (CI) were determined. Heterogeneity was evaluated by I2 statistics. Publication bias was detected using funnel plots. Stata12.0 was used for Begg’s and Egger’s test to quantify whether publication bias. Linear relationship between global cognition and covariates was examined in meta-regression analysis. Results: Twelve studies (n = 1,124) were included. The methodological quality of research is mostly medium. Compared with placebo, n-3PUFAs supplements have benefits on global cognition [SMD = 0.51, 95% CI(0.12, 0.91), p = 0.01]. No significant differences were observed between intervention group and placebo on language fluency, executive functions, and depression. Conclusion: Our findings indicated DHA and/or EPA supplements have benefits on global cognition, and it may also reduce the level of blood amyloid-β (Aβ)-related biomarkers (e.g., Aβ 40, Aβ 42) and inflammatory factors (e.g., 1L-6, 1L-10). Since there are only two relative articles, more research is needed in the future to clarify the relationship.

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“…the most studies showed that anterior cerebral artery stenosis was associated with VCI, which may result in a deterioration in patients' executive function, shortterm memory, verbal fluency, spatial structure, and attention [5,6]. The plausible mechanism is that decreased cerebral blood perfusion leads to neuronal dysfunction [7]. A study with very small sample size demonstrated that approximate half of elderly patients with vertebrobasilar artery (VBA) stenosis might have VCI [8].…”

Section: Introductionmentioning

confidence: 99%

Association of Cerebral Hypoperfusion and Poor Collaterals with Cognitive Impairment in Patients with Severe Vertebrobasilar Artery Stenosis

Zhang,

Fu,

Zhang

2024

ADR

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Background: Effect of stenosis of vertebrobasilar artery (VBA) on cognitive function is elusive. Objective: To investigate association of cerebral hypoperfusion and poor collaterals with vascular cognitive impairment (VCI) in severe VBA stenosis patients. Methods: We consecutively enrolled patients with severe VBA stenosis confirmed by digital subtraction angiography who underwent computed tomographic perfusion (CTP) and cognitive assessments. Patients were divided into poor or good collaterals groups according to the collateral circulation status, and were grouped into different perfusion groups according to CTP. Cognitive function was measured by Montreal Cognitive Assessment (MoCA), Clock Drawing Test, Stroop Color Word Test, Trail Making Test, Digital Span Test, Auditory Verbal Learning Test, and Boston Naming Test scales. The association of cerebral perfusion and collaterals with VCI were explored. Results: Among 88 eligible patients, VCI occurred in 51 (57.9%) patients experienced. Poor collateral was present in 73 (83.0%) patients, and hypoperfusion in 64 (72.7%). Compared with normal perfusion patients, the odds ratio with 95% confidence interval for VCI was 12.5 (3.7–42.4) for overall hypoperfusion, 31.0 (7.1–135.5) for multiple site hypoperfusion, 3.3 (1.0–10.5) for poor collaterals, and 0.1 (0–0.6) for presence of posterior communicating artery (PcoA) compensated for posterior cerebral artery (PCA) and basilar artery (BA). Additionally, decreased scores of cognitive function tests occurred in patients with decompensated perfusion or poor collaterals. Conclusions: Hypoperfusion and poor collaterals were positively associated with cognitive impairment in patients with severe VBA. However, PcoA compensated for the PCA and BA had a protective role in cognitive impairment development.

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Effects of site, cerebral perfusion and degree of cerebral artery stenosis on cognitive function

Cited by 5 publications

References 22 publications

Correlation between Lpa, APO-A, APO-B, and Stenosis of Middle Cerebral Artery in Patients with Cerebral Ischemic Stroke

Correlation between Lpa, APO-A, APO-B, and Stenosis of Middle Cerebral Artery in Patients with Cerebral Ischemic Stroke

N-3 Polyunsaturated Fatty Acids in Elderly with Mild Cognitive Impairment: A Systemic Review and Meta-Analysis

Association of Cerebral Hypoperfusion and Poor Collaterals with Cognitive Impairment in Patients with Severe Vertebrobasilar Artery Stenosis

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