Effects of simvastatin-loaded polymeric micelles on human osteoblast-like MG-63 cells

Liu, Xiangning; Li, Xiaoran; Zhou, Lei; Li, Shaobing; Wang, Zhonglei; Gao, Yan; Jiang, Ying; Lu, Haibin; Wang, Qiangbin; Dai, Jianwu

doi:10.1016/j.colsurfb.2012.06.037

Cited by 36 publications

(33 citation statements)

References 30 publications

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“…Statins are known to upregulate critical osteogenic markers, such as bone morphogenetic protein 2 (BMP-2) 31 , runtrelated gene 2 (RUNX2) 32 , type I collagen (COLA1) 31 , and above all alkaline phosphatase (ALP) 31,33 , and this behaviour has also been observed with simvastatin released from colloidal carriers 34 .…”

Section: Example Of Functional Behaviourmentioning

confidence: 99%

The Effect of Branching (Star Architecture) on Poly(d,l-lactide) (PDLLA) Degradation and Drug Delivery

et al. 2017

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This study focuses on the comparative evaluation of star (branched) and linear poly(L,D-lactic acid) (PDLLA) as degradable materials employed in controlled release.The polymers were prepared via ring-opening polymerization initiated by decanol (linear), pentaerythritol (4-armed star) and dipentaerythritol (6-armed star), and processed both in the form of films and nanoparticles. Independently on the length or number of their arms, star polymers degrade slower than linear polymers, possibly through a surface (vs. bulk) mechanism Further, the release of a model drug (atorvastatin) followed a zero-order-like kinetics for the branched polymers, and a first order kinetics for linear PDLLA. Using NHOst osteoblastic cells, both linear and star polymers were devoid of any significant toxicity and released atorvastatin in a bioavailable form; cell adhesion was considerably lower on star polymer films, and the slower release from their nanoparticles appeared to be beneficial to avoid atorvastatin overdosing.

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Section: Example Of Functional Behaviourmentioning

confidence: 99%

The Effect of Branching (Star Architecture) on Poly(d,l-lactide) (PDLLA) Degradation and Drug Delivery

et al. 2017

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“…As in our previous study, 19 SV-loaded micelles were prepared by a membrane dialysis method. Briefly, 100 mg of TC-PECL polymer and a fixed amount of SV were dissolved in 16 mL acetone.…”

Section: Preparation and Properties Of Tc-grafted Pecl Micelles Prepamentioning

confidence: 99%

“…17,18 As the polymeric micellar system is considered promising for enhancing the bioavailability and reducing the toxic side effects of hydrophobic drugs, SV-loaded polymeric micelles with sustained-release profiles were developed with preferable bioavailability in our previous study. 19 Then, in our additional previous study, SV-loaded polymeric micelles were loaded in titania nanotube (TNT) arrays to develop a local delivery system. 11 However, a big difficulty for the application of this delivery system was the lack of bone-targeting effects; SV-loaded polymeric micelles could be rapidly released from the TNTs and spread far from the implant-bone interface, which seemingly prevents the best biological efficiency of SV on the osteoblasts, contributing to osseointegration.…”

Section: Introductionmentioning

confidence: 99%

Study of a new bone-targeting titanium implant–bone interface

Liu¹,

Zhang²,

Li³

et al. 2016

IJN

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“…In our previous study, SV-loaded poly(ethylene glycol)-poly ( -caprolactone) (PECL) micelles with sustained release profiles were developed, and we demonstrated that the SVloaded micelles provided improved bioavailability compared to free SV. 21 We hypothesized that if SV-loaded PECL micelles can be loaded into the TNTs, a local delivery system of SV could be constructed in an attempt at bridging the gap between research and orthopedic applications for greatly enhancing the effects of osseointegration regardless of existing osteoporosis. The aim of the present work was to construct a local delivery system of SV on Ti sheets, that is, SV-loaded TNTs-micelles, and to evaluate the levels of adhesion, proliferation, differentiation and mineralization of osteoblast-like MG-63 cells on Ti samples.…”

Section: Introductionmentioning

confidence: 99%

An In Vitro Study of a Titanium Surface Modified by Simvastatin-Loaded Titania Nanotubes-Micelles

Liu¹,

X²,

S³

et al. 2014

j biomed nanotechnol

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To develop an optimized local delivery system of simvastatin (SV) with improved osseointegration of titanium (Ti) implants, SV-loaded poly(ethylene glycol)-poly(epsilon-caprolactone) (PECL) micelles (80 nm in diameter) were loaded in titania nanotube (TNT) arrays (80-100 nm in diameter and 400 nm in length) that were fabricated by anodizing Ti sheets. An in vitro release experiment was performed and revealed that TNTs and micelles can jointly provide a sustained release of SV, and that TNTs alone might function in drug release. The effect of the Ti surface with TNTs or TNTs-micelles on osteoblast-like MG-63 cells was determined by analyzing cell morphology, cytoskeletal arrangement, early adhesion, proliferation, alkaline phosphatase activity, and intracellular and extracellular osteocalcin content. The results indicate that the Ti surface with SV-loaded TNTs-micelles not only has better able to promote early adhesion, spreading and early differentiation of osteoblasts than the Ti surface with TNTs alone but it is able to promote calcification of osteoblasts. Therefore, a Ti surface with TNTs or TNTs-micelles is expected to promote contact osteogenesis of the Ti implant, thus contributing to early osseointegration of the implant, whereas the osteogenic effect of the Ti surface with TNTs-micelles is expected to be stronger. This local delivery system can bridge the gap between basic research and applied science for a wide range of titanium-based orthopedic implants in diverse bone-loss diseases, including osteoporosis.

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Effects of simvastatin-loaded polymeric micelles on human osteoblast-like MG-63 cells

Cited by 36 publications

References 30 publications

The Effect of Branching (Star Architecture) on Poly(d,l-lactide) (PDLLA) Degradation and Drug Delivery

The Effect of Branching (Star Architecture) on Poly(d,l-lactide) (PDLLA) Degradation and Drug Delivery

Study of a new bone-targeting titanium implant–bone interface

An In Vitro Study of a Titanium Surface Modified by Simvastatin-Loaded Titania Nanotubes-Micelles

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Effects of simvastatin-loaded polymeric micelles on human osteoblast-like MG-63 cells

Cited by 36 publications

References 30 publications

The Effect of Branching (Star Architecture) on Poly(d,l-lactide) (PDLLA) Degradation and Drug Delivery

The Effect of Branching (Star Architecture) on Poly(d,l-lactide) (PDLLA) Degradation and Drug Delivery

Study of a new bone-targeting titanium implant&ndash;bone interface

An In Vitro Study of a Titanium Surface Modified by Simvastatin-Loaded Titania Nanotubes-Micelles

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Product

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Study of a new bone-targeting titanium implant–bone interface