Effects of silver sulfide quantum dots coated with 2-mercaptopropionic acid on genotoxic and apoptotic pathways in vitro

Vardar, Deniz Özkan; Aydın, Sevtap; Hocaoglu, Ibrahim; Acar, Havva Yağcı; Başaran, Nurşen

doi:10.1016/j.cbi.2018.06.032

Cited by 29 publications

(8 citation statements)

References 65 publications

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“…In contrast, incubation of the dual-ligand CQDs on MCF-7 cells showed minimal cell death in the absence of laser irradiation (Figure S9), indicating the strong anticancer effects of PTT. This also verifies that the dual-ligand CQDs have a low cytotoxicity owing to the nontoxic composition of Ag 2 S. − …”

supporting

confidence: 61%

Dual-Ligand Surface Passivation Enables Monodisperse Ag₂S Colloidal Quantum Dots for Efficient Near-Infrared Photothermal Therapy

Yoo,

Jeong,

et al. 2023

ACS Materials Lett.

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supporting

confidence: 61%

Dual-Ligand Surface Passivation Enables Monodisperse Ag₂S Colloidal Quantum Dots for Efficient Near-Infrared Photothermal Therapy

Yoo,

Jeong,

et al. 2023

ACS Materials Lett.

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“…Ag 2 S QDs with 2-mercaptopropionic acid coating have previously also been shown to be nontoxic in vitro (IC: 50− 1000 μg/mL). 33 Finally, QD-metformin was found to induce biological effects in SK-Hep1 cells following 2 h of treatment. Twentyfive ng QDs conjugated with 300 ng metformin promoted increased expression of phosphorylated eNOS and eNOS compared to QD treated cells (Figure 10D).…”

Section: Resultsmentioning

confidence: 97%

“…SK-Hep 1 cells incubation of QDs (250 μg/mL) with/without FSA biopolymer coating and inhibitor treatments for 2, 4, and 24 h in serum-free media did not show any toxicity (Figure C). Ag 2 S QDs with 2-mercaptopropionic acid coating have previously also been shown to be nontoxic in vitro (IC: 50–1000 μg/mL) …”

Section: Resultsmentioning

confidence: 99%

Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots

et al. 2020

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Quantum dots (QDs) are used for imaging and transport of therapeutics. Here we demonstrate rapid absorption across the small intestine and targeted delivery of QDs with bound materials to the liver sinusoidal endothelial cells (LSECs) or hepatocytes in vitro and in vivo following oral administration. QDs were radiolabeled with 3 H-oleic acid, with a fluorescent tag or 14 C-metformin placed within a drug binding site. Three different biopolymer shell coatings were compared (formaldehyde-treated serum albumin (FSA), gelatin, heparin). Passage across the small intestine into mesenteric veins is mediated by clathrin endocytosis and micropinocytosis. 60% of an oral dose of QDs was rapidly distributed to the liver within 30 min, and this increased to 85% with FSA biopolymer coating. Uptake into LSECs also increased 3-fold with FSA coating, while uptake into hepatocytes was increased from 40% to 85% with gelatin biopolymer coating. Localization of QDs to LSECs was confirmed with immunofluorescence and transmission electron microscopy. 85% of QDs were cleared within 24 h of administration. The bioavailability of 14 C-metformin 2 h post-ingestion was increased 5-fold by conjugation with QD-FSA, while uptake of metformin into LSECs was improved 50-fold by using these QDs. Endocytosis of QDs by SK-Hep1 cells (an LSEC immortal cell line) was via clathrin-and caveolae-mediated pathways with QDs taken up into lysosomes. In conclusion, we have shown high specificity targeting of the LSEC or hepatocytes after oral administration of QDs coated with a biopolymer layer of FSA or gelatin, which improved the bioavailability and delivery of metformin to LSECs.

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“…In the table of Cd-free-metal QDs, we can see that the toxicity of InGaP QD was 10 times lower than CdSe QD with the same surface condition, size and treated time (Stern et al, 2008). IC50 of Ag 2 S and AgInS 2 QDs are larger than 1,000 μg/ml and their PLQYs are not low (Vardar et al, 2018;Wang, Kang, & Pan, 2017), which means Agbased QDs are low toxic and suitable for bioimaging. The element of…”

Section: Ic50mentioning

confidence: 96%

Research advance on cell imaging and cytotoxicity of different types of quantum Dots

Huang

Tang

2020

J of Applied Toxicology

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Quantum dots (QDs), as one of the emerging nanomaterials, have been widely studied by scientists due to their advantages and potential in bioimaging, especially cell imaging. Cadmium (Cd)‐based QDs, which have the best photoluminescence property, have received widespread attention. However, due to the obvious toxicity problem of these QDs, their cell imaging application is hindered. Recently, the emergence of Cd‐free‐metal and metal‐free QDs with lower toxicity makes people consider that Cd‐based QDs may be substituted by these QDs. However, problems of these QDs in cytotoxicity also cannot be ignored. Some reports claimed that their prepared emerging QDs for cell imaging were low toxicity, but there still exist up‐regulation of oxidative stress, inflammation, and apoptosis from other reports. And, up to now, few reports have separately summarized and discussed the issues of cell imaging and cytotoxicity of different types of QDs. Therefore, in this review, we classify QDs as following three types, Cd‐based, Cd‐free‐metal and metal‐free QDs, focus on the cell, the essential unit of life, discuss cell imaging application and cytotoxicity of QDs, and finally elucidate main mechanisms of cytotoxicity respectively. This review provides reference for the toxicity evaluation of QDs and highlights the potential cytotoxicity of Cd‐free QDs.

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Effects of silver sulfide quantum dots coated with 2-mercaptopropionic acid on genotoxic and apoptotic pathways in vitro

Cited by 29 publications

References 65 publications

Dual-Ligand Surface Passivation Enables Monodisperse Ag₂S Colloidal Quantum Dots for Efficient Near-Infrared Photothermal Therapy

Dual-Ligand Surface Passivation Enables Monodisperse Ag₂S Colloidal Quantum Dots for Efficient Near-Infrared Photothermal Therapy

Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots

Research advance on cell imaging and cytotoxicity of different types of quantum Dots

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Effects of silver sulfide quantum dots coated with 2-mercaptopropionic acid on genotoxic and apoptotic pathways in vitro

Cited by 29 publications

References 65 publications

Dual-Ligand Surface Passivation Enables Monodisperse Ag2S Colloidal Quantum Dots for Efficient Near-Infrared Photothermal Therapy

Dual-Ligand Surface Passivation Enables Monodisperse Ag2S Colloidal Quantum Dots for Efficient Near-Infrared Photothermal Therapy

Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots

Research advance on cell imaging and cytotoxicity of different types of quantum Dots

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Product

Resources

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Dual-Ligand Surface Passivation Enables Monodisperse Ag₂S Colloidal Quantum Dots for Efficient Near-Infrared Photothermal Therapy

Dual-Ligand Surface Passivation Enables Monodisperse Ag₂S Colloidal Quantum Dots for Efficient Near-Infrared Photothermal Therapy