Dual-Ligand Surface Passivation Enables Monodisperse Ag₂S Colloidal Quantum Dots for Efficient Near-Infrared Photothermal Therapy

Noble Metal Nanoparticle-Based Photothermal Therapy: Development and Application in Effective Cancer Therapy

“…Yoo et al utilized oleic acid and oleylamine as the co-ligands for surface passivation to achieve the enhanced confinement of the CQD morphology, effectively prevented the CQD fusion, and prepared high monodispersity silver sulfide (Ag 2 S) colloidal quantum dots (CQDs) for tumor diagnosis and therapy ( Figure 4 H). Experimental results showed that the CQDs that were synthesized using dual ligands exhibited uniform size distribution, showed efficient photothermal effects under near-infrared laser irradiation ( Figure 4 I), and were able to effectively kill tumor cells [ 64 ]. Bian et al drew inspiration from biomineralization processes to fabricate silver-based peptide-directed mineralized silver nanocages (AgNCs).…”

“…Copyright 2023, Wiley-VCH GmbH; ( E ) Schematic diagram of the synthesis of the HASAIC probe; ( F ) Temperature change at tumor site under laser irradiation after injection of PBS and probe, respectively; ( G ) Temperature changing curve of tumor site under laser irradiation after injection of PBS and probe [ 62 ]. Copyright 2021, Elsevier B.V. All rights reserved; ( H ) Schematic illustration of ligand passivation on the Ag 2 S CQD surface; ( I ) On-off cycles of the photothermal effect with 500 nM CQDs under 1.5 W/cm 2 [ 64 ]. Copyright 2024, American Chemical Society.…”