Effects of silver nanoparticles on zebrafish (<i>Danio rerio</i>) and <i>Escherichia coli</i> (ATCC 25922): A comparison of toxicity based on total surface area versus mass concentration of particles in a model eukaryotic and prokaryotic system

Bowman, Christopher R.; Bailey, Frank C.; Elrod-Erickson, Matthew; Neigh, Arianne M.; Otter, Ryan R.

doi:10.1002/etc.1881

Cited by 58 publications

(26 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our experiments, the concentrations of NPs detected in finished waters were below the concentrations reported to damage intestinal cells in vitro (Abbott Chalew and Schwab 2013; Koeneman et al 2010) but high enough to cause adverse effects to aquatic organisms (Bowman et al 2012; Gaiser et al 2012). However, NPs and metal ions released from NPs will only increase over time with greater production and use of NP-containing consumer products, leading to a potentially greater health risk.…”

Section: Discussioncontrasting

confidence: 59%

Evaluating Nanoparticle Breakthrough during Drinking Water Treatment

Chalew

Ajmani

Huang

et al. 2013

Environ Health Perspect

138

View full text Add to dashboard Cite

Background: Use of engineered nanoparticles (NPs) in consumer products is resulting in NPs in drinking water sources. Subsequent NP breakthrough into treated drinking water is a potential exposure route and human health threat.Objectives: In this study we investigated the breakthrough of common NPs—silver (Ag), titanium dioxide (TiO2), and zinc oxide (ZnO)—into finished drinking water following conventional and advanced treatment.Methods: NPs were spiked into five experimental waters: groundwater, surface water, synthetic freshwater, synthetic freshwater containing natural organic matter, and tertiary wastewater effluent. Bench-scale coagulation/flocculation/sedimentation simulated conventional treatment, and microfiltration (MF) and ultrafiltration (UF) simulated advanced treatment. We monitored breakthrough of NPs into treated water by turbidity removal and inductively coupled plasma–mass spectrometry (ICP-MS).Results: Conventional treatment resulted in 2–20%, 3–8%, and 48–99% of Ag, TiO2, and ZnO NPs, respectively, or their dissolved ions remaining in finished water. Breakthrough following MF was 1–45% for Ag, 0–44% for TiO2, and 36–83% for ZnO. With UF, NP breakthrough was 0–2%, 0–4%, and 2–96% for Ag, TiO2, and ZnO, respectively. Variability was dependent on NP stability, with less breakthrough of aggregated NPs compared with stable NPs and dissolved NP ions.Conclusions: Although a majority of aggregated or stable NPs were removed by simulated conventional and advanced treatment, NP metals were detectable in finished water. As environmental NP concentrations increase, we need to consider NPs as emerging drinking water contaminants and determine appropriate drinking water treatment processes to fully remove NPs in order to reduce their potential harmful health outcomes.Citation: Abbott Chalew TE, Ajmani GS, Huang H, Schwab KJ. 2013. Evaluating nanoparticle breakthrough during drinking water treatment. Environ Health Perspect 121:1161–1166; http://dx.doi.org/10.1289/ehp.1306574

show abstract

Section: Discussioncontrasting

confidence: 59%

Evaluating Nanoparticle Breakthrough during Drinking Water Treatment

Chalew

Ajmani

Huang

et al. 2013

Environ Health Perspect

138

View full text Add to dashboard Cite

show abstract

“…10,48 Previous studies have demonstrated that toxicity outcomes can vary differently with mass concentration than with exposed surface area of NPs. 49 Because APTES-functionalized NPs have a lower surface area, there would be less exposed surface area per treatment compared to bare silica NPs when the samples are prepared via mass concentration. Therefore, the MTS assay was repeated with the same time points, however, the particle treatments were calculated according to exposed particle surface area per volume of medium (figure 2 D, E and F).…”

Section: Resultsmentioning

confidence: 99%

Amine modification of nonporous silica nanoparticles reduces inflammatory response following intratracheal instillation in murine lungs

et al. 2016

View full text Add to dashboard Cite

Amorphous silica nanoparticles (NPs) possess unique material properties that make them ideal for many different applications. However, the impact of these materials on human and environmental health needs to be established. We investigated nonporous silica NPs both bare and modified with amine functional groups (3-aminopropyltriethoxysilane (APTES)) in order to evaluate the effect of surface chemistry on biocompatibility. In vitro data showed there to be little to no cytotoxicity in a human lung cancer epithelial cell line (A549) for neither bare silica NPs nor amine-functionalized NPs using doses based on both mass concentration (below 200 μg/mL) and exposed total surface area (below 14 m2/L). To assess lung inflammation, C57/B16 mice were administered bare and amine-functionalized silica NPs via intra-tracheal instillation. Two doses (0.1 and 0.5 mg NPs/mouse) were tested using the in vivo model. At the higher dose used, bare silica NPs elicited a significantly higher inflammatory response, as evidence by increased neutrophils and total protein in bronchoalveolar (BAL) fluid compared to amine-functionalized NPs. From this study, we conclude that functionalization of nonporous silica NPs with APTES molecules reduces murine lung inflammation and improves the overall biocompatibility of the nanomaterial.

show abstract

“…Some related the toxicity of NPs to the particle total weight, others to the number of particle per volume [25]. Recently, some studies suggested that the logical way to define particles toxicity is to calculate the dose based on the NPs total surface area also other studies on SiO2 NP S found that the shape of particle is the main cause of particle pathogenesis of lung diseases [26][27][28][29]. The ecotoxicological impact of SiO 2 NPs on freshwater fish has not been completely understood [30].…”

Section: Resultsmentioning

confidence: 99%

Toxicity of N-Nitrosodimethylamine and SiO2 nanoparticles to HaCaT and caco-2 cell lines found in waste water treatment

Almutary¹,

Sanderson²

2017

J Toxicol Health

View full text Add to dashboard Cite

Nanoparticles (NPs) offer the possibility of safe removal of pollutants and microbes in water treatment and purification. Nowadays, NPs are used in the detection and purification of water from chemicals and biological substance such as metals (cadmium, copper, lead and zinc) nutrients (nitrate, nitrite ammonia and phosphate) bacteria, viruses, parasite and antibiotics. Metal containing NPs are among the four classes of particles used commonly in water treatment. Membrane technologies such as Ultrafiltration (UF), Nanofiltration (NF) and Reverse Osmosis (RO) have been widely used all over the world especially for water treatment and desalination. NPs after have been incorporated into membranes gained attention due to its ability to enhance membrane permeability, mechanical properties and selectivity in some cases. However, these membranes are suspected to fouling causing NPs and other contaminate to reach waterways. In this study, we tested the toxicity of SiO 2 NPs synthesised by Stöber method and N-Nitrosodimethylamine (NDMA) as potent known carcinogens forms during chlorination on HaCaT and caco-2 cell lines for 4, 24 and 48h using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays also the morphology and size of SiO 2 determined by Scanning electron microscopy (SEM). After exposure to SiO 2 NPs (concentrations between 0.05-2 mg/mL), the concentration of 2 mg/mL inactivated LDH in both cell lines; however, it did not reduce the metabolic activity of both cell lines when MTT assay used. SEM revealed spherical and uniformed SiO 2 particles with size 200 nm in diameter. NDMA (concentrations between 0.1-1000 µg/mL) inactivated LDH leakage in HaCaT and caco-2 also reduced the metabolic activity of HaCaT cell line at 48 hours exposure. The outcome of this study suggest that a concentration of SiO 2 <2 mg/mL used in water treatment can reduce the risk of nanmaterials toxicity to human and possibly the ecosystem. Our results urgefor more studies on the effect of nanomaterials to the aquatic environment and human exposure to NPs.

show abstract

Effects of silver nanoparticles on zebrafish (Danio rerio) and Escherichia coli (ATCC 25922): A comparison of toxicity based on total surface area versus mass concentration of particles in a model eukaryotic and prokaryotic system

Cited by 58 publications

References 40 publications

Evaluating Nanoparticle Breakthrough during Drinking Water Treatment

Evaluating Nanoparticle Breakthrough during Drinking Water Treatment

Amine modification of nonporous silica nanoparticles reduces inflammatory response following intratracheal instillation in murine lungs

Toxicity of N-Nitrosodimethylamine and SiO2 nanoparticles to HaCaT and caco-2 cell lines found in waste water treatment

Contact Info

Product

Resources

About