Effects of silica and clay nanoparticles on the mechanical properties of poly(vinyl alcohol) nanocomposite hydrogels

Takeno, H.; Aoki, Yukinari; Kimura, Kazuhiko

doi:10.1016/j.colsurfa.2021.127592

Cited by 23 publications

(13 citation statements)

References 30 publications

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“…One example of the approaches is the combination of two types of fillers: clay and SiO 2 nanoparticles, loaded in PVA to produce highly stretchable composite hydrogels. The authors confirm that there are synergistic effects in terms of extensibility due to the integration of both nanoparticles in the polymer network [ 94 ]. In addition, another study has been reported on different particle types and their concentrations; the study was about ZnO nanoparticles loaded into an alginate hydrogel.…”

Section: Resultsmentioning

confidence: 70%

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

et al. 2022

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The advancement of natural-based biomaterials in providing a carrier has revealed a wide range of benefits in the biomedical sciences, particularly in wound healing, tissue engineering and regenerative medicine. Incorporating nanoparticles within polymer composites has been reported to enhance scaffolding performance, cellular interactions and their physico-chemical and biological properties in comparison to analogue composites without nanoparticles. This review summarized the current knowledge of nanoparticles incorporated into natural-based biomaterials with effects on their cellular interactions in wound healing. Although the mechanisms of wound healing and the function of specific cells in wound repair have been partially described, many of the underlying signaling pathways remain unknown. We also reviewed the current understanding and new insights into the wingless/integrated (Wnt)/β-catenin pathway and other signaling pathways of transforming growth factor beta (TGF-β), Notch, and Sonic hedgehog during wound healing. The findings demonstrated that most of the studies reported positive outcomes of biomaterial scaffolds incorporated with nanoparticles on cell attachment, viability, proliferation, and migration. Combining therapies consisting of nanoparticles and biomaterials could be promising for future therapies and better outcomes in tissue engineering and regenerative medicine.

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Section: Resultsmentioning

confidence: 70%

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

et al. 2022

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“…Furthermore, we adopted the Percus–Yevick (PY) hard-sphere model [ 34 ] to calculate the structure factor S ( q ). The detailed representation of the function was described elsewhere [ 13 , 14 ]; in short, the function can be expressed using parameters of an interaction radius R HS and the volume fraction of spheres ϕ .…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, our previous studies clarified that the molecular mass of the constituent polymer is a key factor in the enhancement of mechanical performance [ 11 , 12 ]. Besides, we recently reported that composite hydrogels using two kinds of reinforcing agents such as clay and silica nanoparticles were robust and highly stretchable [ 13 , 14 ]; two identically charged nanoparticles formed multiple crosslinking and suppressed inhomogeneities in the composite hydrogels [ 13 , 14 ]. Thus, the construction of the gel network by multiple crosslinking was effective in fabricating tough polymer hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Robust and Highly Stretchable Chitosan Nanofiber/Alumina-Coated Silica/Carboxylated Poly (Vinyl Alcohol)/Borax Composite Hydrogels Constructed by Multiple Crosslinking

Takeno

Suto

2021

Gels

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We investigated the mechanical and structural properties of composite hydrogels composed of chitosan nanofiber (ChsNF), positively charged alumina-coated silica (ac-SiO2) nanoparticles, carboxylated poly (vinyl alcohol) (cPVA), and borax. ChsNF/cPVA/borax hydrogels without ac-SiO2 exhibited high Young’s modulus but poor elongation, whereas cPVA/ac-SiO2/borax hydrogels without ChsNF had moderate Young’s modulus but high elongation. ChsNF/ac-SiO2/cPVA/borax hydrogels using both ChsNF and ac-SiO2 as reinforcement agents exhibited high extensibility (930%) and high Young′s modulus beyond 1 MPa at a high ac-SiO2 concentration. The network was formed by multiple crosslinking such as the complexation between borate and cPVA, the ionic complexation between ac-SiO2 and cPVA, and the hydrogen bond between ChsNF and cPVA. Structural analysis by synchrotron small-angle X-ray scattering revealed that the nanostructural inhomogeneity in ChsNF/ac-SiO2/cPVA/borax hydrogel was suppressed compared to those of the ChsNF/cPVA/borax and cPVA/ac-SiO2/borax hydrogels.

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“…In another study, PAR-decorated polydopamine nanoparticles were incorporated into the gelatin hydrogels matrix for bone tissue engineering applications [ 103 ]. The results showed that the dispersed nanoparticles not only enhanced the antibacterial and mechanical properties of the hydrogel but also provided high stability and biocompatibility for the matrix [ 104 ].…”

Section: Biomolecule-responsive Hydrogelsmentioning

confidence: 99%

Smart Hydrogels for Advanced Drug Delivery Systems

Bordbar‐Khiabani

Gasik

2022

IJMS

137

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Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering field. Nowadays, drug delivery systems have received great attention and smart hydrogels can be potentially used in these systems due to their high stability, physicochemical properties, and biocompatibility. Smart hydrogels can change their hydrophilicity, swelling ability, physical properties, and molecules permeability, influenced by external stimuli such as pH, temperature, electrical and magnetic fields, light, and the biomolecules’ concentration, thus resulting in the controlled release of the loaded drugs. Herein, this review encompasses the latest investigations in the field of stimuli-responsive drug-loaded hydrogels and our contribution to this matter.

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Effects of silica and clay nanoparticles on the mechanical properties of poly(vinyl alcohol) nanocomposite hydrogels

Cited by 23 publications

References 30 publications

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

Robust and Highly Stretchable Chitosan Nanofiber/Alumina-Coated Silica/Carboxylated Poly (Vinyl Alcohol)/Borax Composite Hydrogels Constructed by Multiple Crosslinking

Smart Hydrogels for Advanced Drug Delivery Systems

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