Effects of shape and charge of colloidal gold nanoparticles in colorimetric determination of DNA sequences

Pylaev, Timofey; Khanadeev, Vitaly A.; Хлебцов, Б. Н.; Дыкман, Л. А.; Богатырев, В. А.; Khlebtsov, N. G.

doi:10.1134/s1061933x11020104

Cited by 5 publications

(6 citation statements)

References 32 publications

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“… Various types of gold plasmon-resonance nanoparticles: 16-nm nanospheres (a) [ 8 ], nanorods (b) [ 15 ], bipyramids (с) [ 16 ], gold nanorods with silver coating (d) [ 17 ], “nanorice” – Fe 2 O 3 nanorods covered by a gold nanoshell (e) [ 18 ], gold nanoshells onto silica cores, SiO 2 /Au (f) [ 19 ] (the inset shows a hollow gold nanoshell [ 20 ]), nanobowls with a gold seed on the bottom (g) [ 21 ],“spiky nanoshells” with SiO 2 /Au cores [ 22 ] (the inset shows a “nanostar” particle [ 23 ]) (h), tetrahedra, octahedra, and cubooctahedra (i) [ 24 ], nanocubes (j) [ 24 ], silver nanocubes and gold-silver nanocages obtained with silver cube templates (insets) (k) [ 25 ], nanonecklaces [ 26 ] (l). The figures were adapted from the cited works.…”

Section: Gold Nanoparticles In Diagnosticsmentioning

confidence: 99%

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Gold Nanoparticles in Biology and Medicine: Recent Advances and Prospects

Дыкман¹,

Khlebtsov²

2011

Acta Naturae

Self Cite

250

161

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Functionalized gold nanoparticles with controlled geometrical and optical properties are the subject of intensive studies and biomedical applications, including genomics, biosensorics, immunoassays, clinical chemistry, laser phototherapy of cancer cells and tumors, the targeted delivery of drugs, DNA and antigens, optical bioimaging and the monitoring of cells and tissues with the use of state-of-the-art detection systems. This work will provide an overview of the recent advances and current challenges facing the biomedical application of gold nanoparticles of various sizes, shapes, and structures. The review is focused on the application of gold nanoparticle conjugates in biomedical diagnostics and analytics, photothermal and photodynamic therapies, as a carrier for delivering target molecules, and on the immunological and toxicological properties. Keeping in mind the huge volume and high speed of the data update rate, 2/3 of our reference list (certainly restricted to 250 Refs.) includes publications encompassing the past 5 years.

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Section: Gold Nanoparticles In Diagnosticsmentioning

confidence: 99%

“…In the optimized version where absorption spectroscopy is used [ 79 ], the detection limit was reduced to 0.1 pM. It has been recently demonstrated that positively charged GNP coated with CTAB can be used for the detection of DNA targets in combination with spectroscopy and dynamic scattering methods [ 15 ].…”

Section: Gold Nanoparticles In Diagnosticsmentioning

confidence: 99%

Gold Nanoparticles in Biology and Medicine: Recent Advances and Prospects

Дыкман¹,

Khlebtsov²

2011

Acta Naturae

Self Cite

250

161

View full text Add to dashboard Cite

show abstract

“…[10][11][12][13][14] In the past decades, Au nanorods have been extensively applied in the field of non-aggregation colorimetricbased biosensing. 23 However, one of the disadvantages of aggregation-based detection is that Au nanorods are unstable and easily coagulate under external environmental changes such as the charge of the colloidal particles, 24 pH value 25,26 and ion strength induced by NaCl. Based on this mechanism, a series of different colorimetric sensors were designed.…”

Section: Introductionmentioning

confidence: 99%

“…21,22 The assembly of Au nanorods in the side-by-side and end-to-end fashions were also applied to the detection of an environmental toxin. 23 However, one of the disadvantages of aggregation-based detection is that Au nanorods are unstable and easily coagulate under external environmental changes such as the charge of the colloidal particles, 24 pH value 25,26 and ion strength induced by NaCl. 27 As more and more nanoparticles with a tailored morphology are fabricated, silver triangular prisms are also utilized for colorimetric detection.…”

Section: Introductionmentioning

confidence: 99%

A promising direct visualization of an Au@Ag nanorod-based colorimetric sensor for trace detection of alpha-fetoprotein

Zhang

Zhu

et al. 2015

J. Mater. Chem. C

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The Ag coating-induced blue shift and enhancement of longitudinal plasmon of Au nanorods result in abundant and tunable optical absorptions in the visible region, which leads to the Au@Ag nanorod becoming a good candidate for colorimetric sensing. In this paper, we have reported an effective and simple approach for visualization detection of alpha-fetoprotein (AFP) based on Au@Ag core-shell nanorods. The AFP concentration-dependent colloid color of Au@Ag core-shell nanorods could change from green to gray, olivine to brown, and even blue to violet to pink, which are more varied color changes compared with the traditional red to blue color change. Besides, as the Ag shell thickness is increased, a dip was observed, which is located between two strong absorption peaks. The change of the dip is proposed as a new biosensor parameter for biomolecule detection based on absorption spectra.AFP concentration detection could be realized according to the change of the position and intensity of the dip, which has not been reported in the biomolecule detection field so far. Au@Ag core-shell nanorods with a small aspect ratio of inner Au nanorods are more suitable for direct read-out visualization, with a color change from blue to violet to pink. From the point of view of spectra analysis, Au@Ag core-shell nanorods with a greater aspect ratio of inner Au nanorods show higher spectral sensitivity. Furthermore, it is found that non-centrifuged Au@Ag core-shell nanorods are preferentially assembled in a side-by-side fashion with the addition of AFP, which will provide new approaches for other kinds of nanorods in controllable assembly fashions.

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“…magnetism, and optical properties thanks for their small (10-100 nm) sizes [5][6][7]. Nanomaterials, when combined with biological and molecular tools, exhibit many potential applications in biotechnological and bioanalytical applications; therefore, nanomaterials have many applications in bioassay, biological sensors, drug delivery, and nanoscale design [5,8,9].…”

mentioning

confidence: 99%

Gold nanoparticle-based colorimetric platform technology as rapid and efficient bacterial pathogens detection method from various sources

Shafiei

Ghasemian

Mostafavi

et al. 2019

Reviews in Medical Microbiology

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Rapid, sensitive, and reliable bacterial pathogens detection is a chief requirement. The gold nanoparticles (AuNPs) have numerous applications such as in the detection of biomolecules for their high surface to volume ratio and unique optical property facilitating development of highly efficient AuNPs-based bio-sensing tools. Although various molecular detection methods, such as PCR, real-time PCR, and loop-mediated isothermal amplification are sensitive and convenient, these techniques need elaborate work and require special skills to increase their specificity. Smartly fabricated gold nanoparticle (GNPs) play a role as probes for selective detection of pathogens. The AuNPs-based colorimetric methods have become applicable for rapid, simple, reliable and high-efficient, sensitive, inexpensive, and easy detection of the DNA, RNA, and protein biomolecules. Colorimetric detection using AuNPs has been used for rapid and high precision and multiplex detection of a large number and of bacterial pathogens. AuNPs act in functionalized and unfunctionalized ways. AuNPs-based colorimetric methods have incredible advantages compared with many other bacterial detection methods. In spite of many molecular techniques, AuNPs-based colorimetric methods do not require additional devices, fabrication cost, signal processing and interpretation complexities, and costly and complex instruments. This simple and rapid method is suitable, especially in low-income areas and for large number of samples analysis. In this review, applications of AuNPs and AuNPs-based colorimetric methods for bacterial pathogens detection have been overviewed.

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Effects of shape and charge of colloidal gold nanoparticles in colorimetric determination of DNA sequences

Cited by 5 publications

References 32 publications

Gold Nanoparticles in Biology and Medicine: Recent Advances and Prospects

Gold Nanoparticles in Biology and Medicine: Recent Advances and Prospects

A promising direct visualization of an Au@Ag nanorod-based colorimetric sensor for trace detection of alpha-fetoprotein

Gold nanoparticle-based colorimetric platform technology as rapid and efficient bacterial pathogens detection method from various sources

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