Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults

Ardekani, Babak A.; Izadi, Neema; Hadid, Somar A.; Meftah, Amir Mohammad; Bachman, Alvin H.

doi:10.1016/j.pscychresns.2020.111107

Cited by 7 publications

(8 citation statements)

References 65 publications

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“…In patients with MCI, lower HPF may be at a higher risk of dementia, and in patients with AD, lower HPF may be at a higher risk of more severe symptoms. While it has been previously reported that there were significant associations between the HPF and cognitive function in cognitively normal older adults [14], here we did not find correlations between the HPF and MoCA scores in the CN group. The discrepancies might be due to the small individual variability of the MoCA scores in the CN group.…”

Section: Discussioncontrasting

confidence: 96%

“…Second, we examined whether and how hippocampal volumetric integrity would be associated with cognitive ability as measured by the Montreal Cognitive Assessment (MoCA), a popular screening tool for cognitive function impairment [ 22 ]. As associations between the HPF and cognitive ability have been reported in normal aging [ 14 ], we hypothesized there would be associations between the HPF and cognitive ability across participants. Lastly, we explored the coupling between hippocampal atrophy and cortical grey matter atrophy during AD progression.…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that the HPF can be used to classify stable MCI patients from those who are transitioning to AD [11]. Studies have reported that HPF values reduce with age [14,15] and dementia severity, with AD patients having the lowest values, followed by MCI patients and then healthy controls [15]. In both normal aging and AD groups, there was right asymmetry in HPF [14,15], and the HPF values were positively associated with cognitive ability in normal aging [14].…”

Section: Introductionmentioning

confidence: 99%

“…Studies have reported that HPF values reduce with age [14,15] and dementia severity, with AD patients having the lowest values, followed by MCI patients and then healthy controls [15]. In both normal aging and AD groups, there was right asymmetry in HPF [14,15], and the HPF values were positively associated with cognitive ability in normal aging [14]. A few studies have shown HPF to be more sensitive than hippocampal volume in classifying AD patients and controls [10] and patients with first-episode psychosis [16].…”

Section: Introductionmentioning

confidence: 99%

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Coupling Between Hippocampal Parenchymal Fraction and Cortical Grey Matter Atrophy at Different Stages of Cognitive Decline

Xiao

Liao

Huang

et al. 2023

JAD

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Background: Hippocampal atrophy is a significant brain marker of pathology in Alzheimer’s disease (AD). The hippocampal parenchymal fraction (HPF) was recently developed to better assess the hippocampal volumetric integrity, and it has been shown to be a sensitive measure of hippocampal atrophy in AD. Objective: To investigate the clinical relevance of hippocampal volumetric integrity as measured by the HPF and the coupling between the HPF and brain atrophy during AD progression. Methods: We included data from 143 cognitively normal (CN), 101 mild cognitive impairment (MCI), and 125 AD participants. We examined group differences in the HPF, associations between HPF and cognitive ability, and coupling between the HPF and cortical grey matter volume in the CN, MCI, and AD groups. Results: We observed progressive decreases in HPF from CN to MCI and from MCI to AD, and increases in the asymmetry of HPF, with the lowest asymmetry index (AI) in the CN group and the highest AI in the AD group. There was a significant association between HPF and cognitive ability across participants. The coupling between HPF and cortical regions was observed in bilateral hippocampus, parahippocampal gyrus, temporal, frontal, and occipital regions, thalamus, and amygdala in CN, MCI, and AD groups, with a greater involvement of temporal, occipital, frontal, and subcortical regions in MCI and AD patients, especially in AD patients. Conclusion: This study provides novel evidence for the neuroanatomical basis of cognitive decline and brain atrophy during AD progression, which may have important clinical implications for the prognosis of AD.

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Section: Discussioncontrasting

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Coupling Between Hippocampal Parenchymal Fraction and Cortical Grey Matter Atrophy at Different Stages of Cognitive Decline

Xiao

Liao

Huang

et al. 2023

JAD

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“…The volumes of the structures were obtained from the binary segmentations by counting voxels and multiplying with the voxel dimensions. In multivariate regression analyses, we controlled for known confounders, namely age [ 38 , 39 , 40 ], sex [ 38 , 41 , 42 , 43 ], and intracranial volume (ICV) [ 18 , 44 , 45 , 46 ] defined as the total volume within the skull including left and right hemispheres, brainstem, cerebellum and cerebrospinal fluid. The regression model used was:

where

are coefficients for cVEMP, ICV, age and sex respectively, and

is the constant term.…”

Section: Methodsmentioning

confidence: 99%

Vestibular function and cortical and sub-cortical alterations in an aging population

Jacob

Tward

Resnick

et al. 2020

Heliyon

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While it is well known that the vestibular system is responsible for maintaining balance, posture and coordination, there is increasing evidence that it also plays an important role in cognition. Moreover, a growing number of epidemiological studies are demonstrating a link between vestibular dysfunction and cognitive deficits in older adults; however, the exact pathways through which vestibular loss may affect cognition are unknown. In this cross-sectional study, we sought to identify relationships between vestibular function and variation in morphometry in brain structures from structural neuroimaging. We used a subset of 80 participants from the Baltimore Longitudinal Study of Aging, who had both brain MRI and vestibular physiological data acquired during the same visit. Vestibular function was evaluated through the cervical vestibular-evoked myogenic potential (cVEMP). The brain structures of interest that we analyzed were the hippocampus, amygdala, thalamus, caudate nucleus, putamen, insula, entorhinal cortex (ERC), trans-entorhinal cortex (TEC) and perirhinal cortex, as these structures comprise or are connected with the putative “vestibular cortex.” We modeled the volume and shape of these structures as a function of the presence/absence of cVEMP and the cVEMP amplitude, adjusting for age and sex. We observed reduced overall volumes of the hippocampus and the ERC associated with poorer vestibular function. In addition, we also found significant relationships between the shape of the hippocampus (p = 0.0008), amygdala (p = 0.01), thalamus (p = 0.008), caudate nucleus (p = 0.002), putamen (p = 0.02), and ERC-TEC complex (p = 0.008) and vestibular function. These findings provide novel insight into the multiple pathways through which vestibular loss may impact brain structures that are critically involved in spatial memory, navigation and orientation.

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Missing apolipoprotein E ɛ4 allele associated with nonamnestic Alzheimer’s disease in a Tunisian population

Fray

Achouri-Rassas

Belal

et al. 2022

J Genet

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Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults

Cited by 7 publications

References 65 publications

Coupling Between Hippocampal Parenchymal Fraction and Cortical Grey Matter Atrophy at Different Stages of Cognitive Decline

Coupling Between Hippocampal Parenchymal Fraction and Cortical Grey Matter Atrophy at Different Stages of Cognitive Decline

Vestibular function and cortical and sub-cortical alterations in an aging population

Missing apolipoprotein E ɛ4 allele associated with nonamnestic Alzheimer’s disease in a Tunisian population

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