Missing apolipoprotein E ɛ4 allele associated with nonamnestic Alzheimer’s disease in a Tunisian population

Fray, Saloua; Achouri-Rassas, Afef; Belal, Samir; Messaoud, Taieb

doi:10.1007/s12041-022-01384-9

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…A total of 80 classic neuropsychological tests, batteries, scales, and questionnaires were used in this literature (see Table 3 for a full list), with the most frequent five tests being MoCA, MMSE, Brief Visuospatial Memory Test‐Revised, Brief International Cognitive Assessment for Multiple Sclerosis, and ACE‐III. By far, Arabic versions of MoCA and MMSE are the most used tests in the MENA region ( n = 10 21 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ), ( n = 8 20 , 45 , 54 , 55 , 56 , 57 , 58 , 59 ), respectively. Interestingly, one study introduced the first Arabic memory test, The Verbal Memory Arabic Test.…”

Section: The Case Of the Mena Regionmentioning

confidence: 99%

Cognitive decline assessment in speakers of understudied languages

Hatahet,

Roser,

Seghier

2023

A&D Transl Res & Clin Interv

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Projected trends in population aging have forecasted a massive increase in the number of people with dementia, in particular in sub‐Saharan Africa and the Middle East and North Africa (MENA) region. Cognitive decline is a significant marker for dementia, typically assessed with standardized neuropsychological tools that have been validated in some well‐researched languages such as English. However, with the existing language diversity, current tools cannot cater to speakers of understudied languages, putting these populations at a disadvantage when it comes to access to early and accurate diagnosis of dementia. Here, we shed light on the detrimental impact of this language gap in the context of the MENA region, highlighting inadequate tools and an unacceptable lack of expertise for a MENA population of a half billion people. Our perspective calls for more research to unravel the exact impact of the language gap on the quality of cognitive decline assessment in speakers of understudied languages.Highlights Cognitive decline is a marker for dementia, assessed with neuropsychological tests. There is a lack of culturally valid tests for speakers of understudied languages. For example, suboptimal cognitive tests are used in the Middle East and North Africa region. Linguistic diversity should be considered in the development of cognitive tests.

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Section: The Case Of the Mena Regionmentioning

confidence: 99%

Cognitive decline assessment in speakers of understudied languages

Hatahet,

Roser,

Seghier

2023

A&D Transl Res & Clin Interv

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Association of the apolipoprotein E ε4 allele in a Serbian population with Alzheimer’s dementia

Bašić

Milošević

Djordjević

et al. 2023

ARCH BIOL SCI BELGRA

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Although single nucleotide polymorphisms rs429358 and rs7412 in the apolipoprotein E gene (APOE) are widely investigated to analyze APOE alleles, there are no data on their association with Alzheimer?s disease (AD) dementia in a Serbian population. This study aimed to investigate the distribution of APOE ?2/?3/?4 alleles in patients with dementia due to AD and cognitively unimpaired subjects and to assess the association of the APOE ?4 allele with disease risk in the Serbian population. A case-control study included patients with dementia due to AD and cognitively unimpaired individuals. APOE rs429358 and rs7412 were analyzed using the Real-Time PCR method with allelespecific TaqMan assays, followed by APOE ?2/?3/?4 allele carrier status analysis. Patients had a significantly higher frequency of the APOE ?4 allele than the control group (P<0.001). The APOE ?4 allele was found to be associated with a 3-fold higher risk of AD dementia compared to the reference ?3 allele (P<0.001). In conclusion, this is the first study to suggest that carriers of the APOE ?4 allele have a higher risk of developing dementia due to AD than those who carry the APOE ?3 allele in the Serbian population.

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Missing apolipoprotein E ɛ4 allele associated with nonamnestic Alzheimer’s disease in a Tunisian population

Cited by 2 publications

References 44 publications

Cognitive decline assessment in speakers of understudied languages

Cognitive decline assessment in speakers of understudied languages

Association of the apolipoprotein E ε4 allele in a Serbian population with Alzheimer’s dementia

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