Effects of sevoflurane general anesthesia: immunological studies in mice

Puig, N; Ferrero, P.; Bay, María Luisa; Hidalgo, Guillermo; Valenti, J. L.; Amerio, N; Elena, G

doi:10.1016/s1567-5769(01)00151-5

Cited by 52 publications

(40 citation statements)

References 29 publications

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“…According to MORISAKI et al (1998), total leukocyte count did not change following sevoflurane anesthesia, but the number of neutrophils decreased and the number of lymphocytes increased, which is in contrast to the results obtained in our study. Unlike the study cited above, the results reported by PUIG et al (2002) are consistent with our study. as mentioned above, they used 3% sevoflurane anesthesia in mice and demonstrated that it induced changes to the peripheral blood total leukocyte count, B-lymphocyte count, CD4…”

supporting

confidence: 92%

“…It has been demonstrated that anesthetic agents given during any procedure may lead to immunosuppression (KELBEL and WEISS, 2001). Most clinical studies have been focused on the combined effects of surgery and anesthesia on the immune function (MORISAKI et al, 1998, DELOGU et al, 2000SCHNEEMILCH and BANK, 2001;HORI et al, 2003;COCELLI et al, 2012), with only a few studies dealing specifically with anesthetic agents (DAGAN et al, 1989;MOUDGIL and SINGAL, 1997;PUIG et al, 2002;ELENA et al, 2003;MÜLLER-EDENBORN et al, 2015).…”

mentioning

confidence: 99%

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The effect of repeated sevoflurane and nitrous oxide exposure on immunity in rabbits

Adam¹,

Marin²,

Popović³

et al. 2018

Vet. arhiv

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: The effect of repeated sevoflurane and nitrous oxide exposure on immunity in rabbits. Vet. arhiv 88, 37-48, 2018. ABSTrACTThe aim of this study was to investigate the effect of repeated/prolonged exposure to sevoflurane and nitrous oxide on the immune response in rabbits. Venous blood samples were obtained from twenty New Zealand rabbits, randomly allocated to four groups of five rabbits each. Group A rabbits served as controls, breathing 100% oxygen, group B rabbits inhaled a mixture of oxygen and nitrous oxide, group C inhaled a combination of oxygen and sevoflurane, and group D inhaled a combination of oxygen, nitrous oxide and sevoflurane. Flow cytometry was used to determine the proportions of CD45+ and CD21 + leukocytes subpopulations. Peripheral lymph nodes, lungs and spleen were sampled and subjected to histologic examination. the greatest changes in the proportion of CD21 + and CD45 + cell counts on day 0 and day 21 showed a 30% decrease. This study demonstrated that sevoflurane alone and in combination with nitrous oxide exerts a strong immunosuppressive effect, modifying the physiological values of the hematologic parameters, and inducing histopathological alterations in peripheral lymph node, lung and spleen tissues.

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confidence: 92%

mentioning

confidence: 99%

The effect of repeated sevoflurane and nitrous oxide exposure on immunity in rabbits

Adam¹,

Marin²,

Popović³

et al. 2018

Vet. arhiv

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“…The effect on the number of B lymphocytes depends on the drug type. Isoflurane and desflurane increase the cell numbers 13,25 , while sevoflurane and propofol can increase 13,14,27 or decrease 18,20 it. Anaesthetics also affect B lymphocyte cell count and decreases cytotoxic activity 7,14 .…”

Section: B Lymphocytes (Cd19)mentioning

confidence: 95%

“…activation. Halothane increases the antibody titre 8 , and, as sevoflurane does, it increases the primary and secondary responses 5,8,9,20,21,27 .…”

Section: Il-6mentioning

confidence: 99%

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Untitled

2013

OA Anaesthetics

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IntroductionThe immune system protects us from infections through coordinate action of its components. Patients and animals undergoing anaesthesia and surgery show alterations in the immune response. In this paper, we review the effects of some of the most common anaesthetic drugs on the immune system, in particular the effects within 24 hours after their administration, describing their effects on cells and cytokines of the innate and acquired immune system. Discussion As it is difficult to isolate the effects of anaesthetic drugs in the case of surgery, diverse in vitro studies with human immune cells or in vivo with animal models have been used to study the effect of anaesthetic drugs on the immune system. These studies have demonstrated diverse effects, such as changes in immune cell counts and functionality, and on the secretion patterns of diverse cytokines affecting the inflammatory response in the postoperative period. Conclusion Effects of anaesthetic drugs on the immune system are clinically important because the amount and function of the immune cells, as well as the balance between pro-and anti-inflammatory cytokines secretion, are related to postoperative infections and tissue injury.

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Effects of Untreated Pain, Anesthesia, and Analgesia in Animal Experimentation

Jirkof

Potschka

2021

Experimental Design and Reproducibility in Preclinical Animal Studies

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Effects of sevoflurane general anesthesia: immunological studies in mice

Cited by 52 publications

References 29 publications

The effect of repeated sevoflurane and nitrous oxide exposure on immunity in rabbits

The effect of repeated sevoflurane and nitrous oxide exposure on immunity in rabbits

Untitled

Effects of Untreated Pain, Anesthesia, and Analgesia in Animal Experimentation

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