Effects of serotonin receptor agonists and antagonists on offensive aggression in mice

Lindgren, Tone; Kantak, Kathleen M.

doi:10.1002/1098-2337(1987)13:2<87::aid-ab2480130205>3.0.co;2-0

Cited by 41 publications

(13 citation statements)

References 25 publications

(14 reference statements)

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“…These observations of rather unselective antiaggressive effects of 8-OH-DPAT, buspirone, and ipsapirone are in line with what has been reported before by several authors using various aggression paradigms (Tompkins et al 1980;Flannely et al 1985;Lindgren and Kantak 1987;McMillen et al 1988;Blanchard et al 1988;Nikulina 1991;Olivier et al 1994Olivier et al , 1995Sanchez and Hyttel 1994;Miczek et al 1995;Bell andHobson 1994, Muehlenkamp et al 1995). Actually, the reduction in offensive aggression by these 5-HT 1A receptor agonists is generally explained by the predominant quiescent/akinetic (i.e., the 5-HT 1A receptor-mediated behavioral syndrome) effects these compounds induce due to their high-efficacy activation of postsynaptic 5-HT 1A receptors responsible for this (Tricklebank 1985;;Scott et al 1994;Millan et al 1994).…”

Section: Discussionsupporting

confidence: 87%

“…The potent anti-aggressive properties of 5-HT 1A receptor agonists have consistently been reported (Tompkins et al 1980; Flannelly et al 1985;Lindgren and Kantak 1987;McMillen et al 1988;Blanchard et al 1988;Nikulina 1991;Olivier et al 1994Olivier et al , 1995Sanchez and Hyttel 1994;Miczek et al 1995;Bell and Hobson 1994, Muehlenkamp et al 1995), but evidence on whether this occurs via a pre-or postsynaptic receptor mechanism is conflicting. Thus, it has been shown that depletion of neuronal 5-HT or lesioning of presynaptic function (with PCPA or 5,7 DHT respectively) either did not change (Sijbesma et al 1991) or even potentiates (Sanchez and Hyttel 1994) the anti-aggressive effect of 5-HT 1A receptor agonists, suggesting a postsynaptic site of action.…”

Section: Discussionmentioning

confidence: 99%

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Somatodendritic 5-HT1A Autoreceptors Mediate the Anti-Aggressive Actions of 5-HT1A Receptor Agonists in Rats An Ethopharmacological Study with S-15535, Alnespirone, and WAY-100635

Boer

Lesourd

Mocaër

et al. 2000

Neuropsychopharmacology

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Serotonin; Hypothermia; Rat A dysregulation of brain serotoninergic (5-HT) transmission, particularly at 5-HT 1A receptors, is implicated in the pathophysiology of anxiety, depression, and impulsive states like violent aggression (i.e., Coplan et al. 1995;Maes and Meltzer 1995;Berman et al. 1997). CorFrom the Department of Animal Physiology (SFB, JMK), University of Groningen, The Netherlands; and the Institut de Recherches Internationales Servier (ML, EM), Courbevoie Cedex, France.Address correspondence to: Dr. Sietse F. de Boer, Department of Animal Physiology, University of Groningen, PO Box 14, 9750 AA Haren, The Netherlands.Received January 13, 1999; revised August 5, 1999; accepted January 4, 2000. N EUROPSYCHOPHARMACOLOGY 2000 -VOL . 23 , NO . 1 Somatodendritic 5-HT 1A Autoreceptors and Aggression 21 respondingly, various 5-HT 1A receptor agonists exert potent anxiolytic, antidepressant, and anti-aggressive properties in experimental models (see for reviews, De Vry 1995;Broekkamp et al. 1995;Miczek et al. 1995;Olivier et al. 1995) and in man (Stahl 1994;Mann 1995;Ratey et al. 1991).Brain 5-HT 1A receptors are located postsynaptically, on various neurons in the limbic system and cortex, and presynaptically, as somatodendritic autoreceptors on the perikarya of serotoninergic neurons in the dorsal and median raphé (Palacios et al. 1987(Palacios et al. , 1990. Actions at both pre-and postsynaptic 5-HT 1A receptors appears to play a role in the therapeutic properties of 5-HT 1A receptor ligands, although their relative contribution remains to be clarified more precisely. To date, the anxiolytic-like effects of 5-HT 1A receptor agonists are generally ascribed to a selective stimulation of somatodendritic 5-HT 1A autoreceptors, thereby inhibiting the firing activity of 5-HT neurons consequently leading to a transient decrease in (anxiety-enhanced) 5-HT neurotransmission in limbic brain areas (Kidd et al. 1993;Schreiber and De Vry 1993;Millan et al. 1997). On the other hand, the rapid (i.e., immediately after drug administration) antidepressant-like effects of the same drugs mainly involve the acute stimulation of certain forebrain populations of postsynaptic 5-HT 1A receptors (Martin et al. 1990). Whereas a net increase in the tonic activation of these postsynaptic receptors is thought to underlie the therapeutic effects of several classes of antidepressants for long-term treatment Haddjeri et al. 1998).Concerning the potent anti-aggressive properties of 5-HT 1A receptor agonists, evidence on whether this occurs via a pre-or postsynaptic receptor mechanisms is conflicting. (e.g., McMillen et al. 1988;Sijbesma et al. 1991;Mos et al. 1993;Millan et al. 1997;De Almeida and Lucion 1997;Sanchez and Hyttel 1994). However, all these studies investigating the role of pre-and/or postsynaptic receptors in the anti-aggressive actions of 5-HT 1A receptor agonists have relied on 5-HT lesion/depletion or intracranial microinjection techniques, and it must be realized that both experimental approaches have limitati...

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Somatodendritic 5-HT1A Autoreceptors Mediate the Anti-Aggressive Actions of 5-HT1A Receptor Agonists in Rats An Ethopharmacological Study with S-15535, Alnespirone, and WAY-100635

Boer

Lesourd

Mocaër

et al. 2000

Neuropsychopharmacology

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“…From a pharmacological perspective, research has focused on the 5-HT 1 receptor family as being primarily involved in the suppression of offensive aggression (Lindgren and Kantak 1987;Muehlenkamp et al 1995). Selective 5-HT 1A agonists such as 8-OH-DPAT and flesinoxan attenuate aggressive behavior in mice and rats in a dose-dependent manner (Olivier et al 1989b;Mos et al 1993;Sanchez et al 1993;Miczek et al 1998b).…”

Section: Introductionmentioning

confidence: 96%

Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT1B receptor agonist CP-94,253

1999

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“…Pharmacological reduction of the availability of 5-HT and its precursors increases aggressive behaviors (Chamberlain et al 1987;Young et al 1989). Conversely, pharmacologically increasing availability of 5-HT and its precursors results in reduced rates of aggression (Lindgren and Kantak 1987;Raleigh 1987;Shea et al 1990; see review by Olivier et al 1991). Some patients who exhibit selfaggressivity have low CSF 5-HIAA concentrations (Lopez-Ibor et al 1985).…”

mentioning

confidence: 99%

Effect of Tryptophan Treatment on Self-Biting and Central Nervous System Serotonin Metabolism in Rhesus Monkeys (Macaca mulatta)

Weld

Mench

Woodward

et al. 1998

Neuropsychopharmacology

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Two studies were conducted to examine the effects of oral L-tryptophan (TRP) supplementation as a treatment for self-injurious behavior (SIB) and to investigate behavior Meyer-Holzapfel 1968;Jones and Barraclough 1978). In humans, SIB has been described as representing a continuum of behavior ranging from occasional noninjurious biting, scratching, and head banging to persistent self-biting and cutting associated with severe physical injuries (Harris 1995;Walsh and Rosen 1988). SIB also occurs in rhesus monkeys, most often as a result of self-biting (Tinklepaugh 1928;Erwin et al. 1973;Capitanio 1986). A retrospective study documenting the incidence of wounding in three primate colonies (Bayne et al. 1995) showed that, of 253 monkeys studied, 0.8% engaged in self-injurious behavior that resulted in wounds requiring veterinary treatment. Although severe self-biting in nonhuman primates is a relatively uncommon phenomenon, it nevertheless remains a serious concern, because it can lead to severe and sometimes fatal injuries.

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Effects of serotonin receptor agonists and antagonists on offensive aggression in mice

Cited by 41 publications

References 25 publications

Somatodendritic 5-HT1A Autoreceptors Mediate the Anti-Aggressive Actions of 5-HT1A Receptor Agonists in Rats An Ethopharmacological Study with S-15535, Alnespirone, and WAY-100635

Somatodendritic 5-HT1A Autoreceptors Mediate the Anti-Aggressive Actions of 5-HT1A Receptor Agonists in Rats An Ethopharmacological Study with S-15535, Alnespirone, and WAY-100635

Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT1B receptor agonist CP-94,253

Effect of Tryptophan Treatment on Self-Biting and Central Nervous System Serotonin Metabolism in Rhesus Monkeys (Macaca mulatta)

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