Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT1B receptor agonist CP-94,253

Fish, Eric W.; Faccidomo, Sara; Miczek, Klaus A.

doi:10.1007/pl00005484

Cited by 149 publications

(156 citation statements)

References 51 publications

(81 reference statements)

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“…Both male and female mice that lack functional expression of the 5-HT 1B receptor gene (5-HT 1B Ϫ/Ϫ ) are more aggressive (Saudou et al, 1994;Bouwknecht et al, 2001), consistent with the anti-aggressive effect of several 5-HT 1B agonists including eltoprazine (Olivier et al, 1990), CP-94,253 (Fish et al, 1999;Chiavegatto et al, 2001), zolmitriptan , and anpirtoline (Rilke et al, 2001;Miczek and de Almeida, 2001;de Almeida and Miczek, 2002). Although agonists at 5-HT 1A receptors also decrease aggression in rodents (Olivier et al, 1995;Miczek et al, 1998), the mutant mice lacking 5-HT 1A receptors are more anxious, less reactive, and possibly less aggressive (Zhuang et al, 1999).…”

Section: Serotonin (5-ht) and Male Aggressionmentioning

confidence: 65%

Interaction of nitric oxide and serotonin in aggressive behavior

Chiavegatto

Nelson

2003

Hormones and Behavior

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Nitric oxide (NO) modulates many behavioral and neuroendocrine responses. Genetic or pharmacological inhibition of the synthetic enzyme that produces NO in neurons evokes elevated and sustained aggression in male mice. Recently, the excessive aggressive and impulsive traits of neuronal NO synthase knockout (nNOS Ϫ/Ϫ ) mice were shown to be caused by reductions in serotonin (5-HT) turnover and deficient 5-HT 1A and 5-HT 1B receptor function in brain regions regulating emotion. The consistently high levels of aggression observed in nNOS Ϫ/Ϫ mice could be reversed by 5-HT precursors and by treatment with specific 5-HT 1A and 5-HT 1B receptor agonists. The expression of the aggressive phenotype of nNOS Ϫ/Ϫ knockout mice requires isolated housing prior to testing. The effects of social factors such as housing condition and maternal care can affect 5-HT and aggression, but the interaction among extrinsic factors, 5-HT, NO, and aggression remains unspecified. Taken together, NO appears to play an important role in normal brain 5-HT function and may have significant implications for the treatment of psychiatric disorders characterized by aggressive and impulsive behaviors.

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Section: Serotonin (5-ht) and Male Aggressionmentioning

confidence: 65%

Interaction of nitric oxide and serotonin in aggressive behavior

Chiavegatto

Nelson

2003

Hormones and Behavior

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“…Maternal aggression and 5-HT 1B receptor agonists www.bjournal.com.br temic injections of this compound are also very effective in decreasing species-typical aggressive behavior of male mice in the resident-intruder model and in alcoholheightened aggressive behavior in mice (2) as well as in suppressing the motivation to fight in male mice (13). CP-93,129 and CP-94,253 are highly selective agonists for the 5-HT 1B receptor subtype.…”

Section: A B Cmentioning

confidence: 99%

“…CP-94,253, anpirtoline and zolmitriptan, all 5-HT 1B receptor agonists, when administered systemically have anti-aggressive effects under conditions that induce moderate or escalated levels of aggression such as social instigation, self-administration of alcohol or frustration, without impairing non-aggressive activities (2,3). This 5-HT receptor subtype received considerable attention when mutant 129/Sv mice lacking the gene for the 5-HT 1B receptor were found to display more aggressive behavior (4,5).…”

mentioning

confidence: 99%

“…Stimulation of 5-HT 1B receptors in the VO PFC proved to effectively reduce aggressive behavior in resident male mice confronting an intruder without discernible side effects (12). From a clinical perspective, it is important to study animal aggression that escalates above the species-typical level (2,3). One experimental approach used to escalate aggressive behavior is to provoke an animal by exposing it to a rival, and this procedure is often referred to as social instigation (17)(18)(19).…”

mentioning

confidence: 99%

“…One experimental approach used to escalate aggressive behavior is to provoke an animal by exposing it to a rival, and this procedure is often referred to as social instigation (17)(18)(19). Most individuals engage in aggressive behavior at twice the usual level after being instigated than without such provocation (2,3). Nearly all evidence about 5-HT 1B receptors and escalated aggression has been obtained from experiments with males, and there is an urgent need to investigate this neurobiological mechanism in female aggression.…”

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confidence: 99%

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Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats

Veiga

Miczek

Lucion

et al. 2007

Braz J Med Biol Res

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Serotonin (5-HT 1B ) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT 1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT 1B receptor agonists 129), microinjected into the VO PFC, on maternal aggressive behavior after social instigation in rats. CP-94,253 (0.56 µg/0.2 µL, N = 8, and 1.0 µg/0.2 µL, N = 8) or CP-93,129 (1.0 µg/0.2 µL, N = 9) was microinjected into the VO PFC of Wistar rats on the 9th day postpartum and 15 min thereafter the aggressive behavior by the resident female against a male intruder was recorded for 10 min. The frequency and duration of aggressive and non-aggressive behaviors were analyzed using ANOVA and post hoc tests. CP-93,129 significantly decreased maternal aggression. The frequency of lateral attacks, bites and pinnings was reduced compared to control, while the non-aggressive behaviors and maternal care were largely unaffected by this treatment. CP-94,253 had no significant effects on aggressive or non-aggressive behaviors when microinjected into the same area of female rats. CP-93,129, a specific 5-HT 1B receptor agonist, administered into the VO PFC reduced maternal aggressive behavior, while the CP-94,253 agonist did not significantly affect this behavior after social instigation in female rats. We conclude that only the 5-HT 1B receptor agonist CP-93,129 administered into the VO PFC decreased aggression in female rats postpartum after social instigation. Correspondence

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Chronic passive exposure to aggression escalates aggressiveness of rat observers

Sano

Lucas

2009

Aggressive Behavior

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Previous studies have documented that exposure to aggression increases aggressiveness of human witnesses. However, the question of whether passive exposure to aggression can exclusively cause a risk of aggressive inclination for observers through a learning process, rather than mimicry effect, has not been readily addressed in the clinical literature. This study aimed to investigate this question by using a simple animal model to test the behavioral effect of chronic passive exposure to aggression. Our results indicate that observer rats that had been passively exposed to aggression for 10 min per day for 23 consecutive days exhibited more aggressive behavior than controls or those groups undergoing a single exposure to passive aggression. Furthermore, aggression levels in the group of 23-day chronic exposure to aggression lasted 16 days after the recovery from exposure to aggression. These data suggest that the development of aggression in this model occurred through a learning process because only chronic exposure to aggression resulted in this behavioral outcome in the long run.

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Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT1B receptor agonist CP-94,253

Abstract: The current results support the hypothesis that activation of 5-HT(1B) receptors modulates very high levels of aggressive behavior in a pharmacologically and behaviorally specific manner.

Cited by 149 publications

References 51 publications

Interaction of nitric oxide and serotonin in aggressive behavior

Interaction of nitric oxide and serotonin in aggressive behavior

Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats

Chronic passive exposure to aggression escalates aggressiveness of rat observers

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