Effects of Self-Assembling Peptide Hydrogel Scaffold on Bone Regeneration with Recombinant Human Bone Morphogenetic Protein-2

Ikeno, Masayuki; Hibi, Hideharu; Kinoshita, K; Hattori, Hiroyuki

doi:10.11607/jomi.te09

Cited by 25 publications

(16 citation statements)

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“…BMP-2 group compared with the negative control group. This result can be attributed to the osteoinductive ability of BMP-2 (Urist, 1965) and agrees with the many other studies of vertical bone augmentation (Ikeno, Hibi, Kinoshita, Hattori, & Ueda, 2013;Jung et al, 2008;Polo et al, 2013).…”

Section: Discussionsupporting

confidence: 92%

“…For the whole VOI, significant increases in the augmented bone width and height, peri‐implant mineralized tissue volume, as well as bone‐to‐implant contact percentage, were observed in the inc.BMP‐2 group compared with the negative control group. This result can be attributed to the osteoinductive ability of BMP‐2 (Urist, ) and agrees with the many other studies of vertical bone augmentation (Ikeno, Hibi, Kinoshita, Hattori, & Ueda, ; Jung et al, ; Polo et al, ).…”

Section: Discussionsupporting

confidence: 90%

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Vertical bone augmentation with simultaneous implantation using deproteinized bovine bone block functionalized with a slow delivery of BMP‐2

Teng

Wei

et al. 2020

Clinical Oral Implants Res

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Objective We hypothesized that a biomimetic calcium phosphate (CaP) coating which incorporates morphogenetic protein 2 (BMP‐2) on the deproteinized bovine bone (DBB) blocks could be used to enhance the vertical alveolar ridge augmentation for the one‐stage onlay surgery with simultaneous implants insertion. We aimed to test this hypothesis in vivo. Material and methods Beagles dogs were used for the study (n = 6 specimens per group). One month after building the edentulous animal model, 4 mm vertical alveolar bone loss were surgically created and four groups of blocks (W × L × H: 7 mm × 10 mm × 4 mm) were randomly fixed onto the reduced alveolar ridge by implants: (a) DBB blocks alone (negative control group); (b) DBB blocks with superficial adsorption of 50 μg BMP‐2 (ad.BMP‐2 group); (c) DBB blocks coated by biomimetic CaP coating which incorporates 50 μg BMP‐2 (inc.BMP‐2 group); and (d) autologous bone blocks (positive control group). After 3 months of healing, samples were harvested for micro‐CT and histomorphometric analyses. Results In histomorphometry, the inc.BMP‐2 group showed a significantly thicker (coronal‐apically) and wider (buccal‐lingually) augmented bone area, better bone‐to‐implant contact than the negative control group. In both the micro‐CT and histomorphometry, the inc.BMP‐2 group showed more mineralized tissue than the negative control group and the inc.BMP‐2 group also showed significantly more newly formed bone and residual grafts than the negative control group in the upper half of the blocks. In micro‐CT, the inc.BMP‐2 group showed significantly more bone‐to‐graft contact percentage than the ad.BMP‐2 group. In both micro‐CT and histomorphometry, the inc.BMP‐2 group showed significantly more percentage of mineralized tissue than the ad.BMP‐2 group. No significant differences were found between the inc.BMP‐2 group and the positive control group either in micro‐CT or in histomorphometry. Conclusions The DBB blocks with coating‐delivered BMP‐2 significantly enhanced the efficacy of vertical alveolar bone augmentation, compared with the unloaded blocks and blocks with adsorbed BMP‐2, in the one‐stage onlay surgery with simultaneous implant insertion.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Vertical bone augmentation with simultaneous implantation using deproteinized bovine bone block functionalized with a slow delivery of BMP‐2

Teng

Wei

et al. 2020

Clinical Oral Implants Res

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“…In another related study, PuraMatrix served as the carrier for recombinant human bone morphogenetic protein-2, which significantly enhances bone regeneration in a bone augmentation rabbit model. 1122 …”

Section: Applicationsmentioning

confidence: 99%

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

et al. 2015

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In this review we intend to provide a relatively comprehensive summary of the work of supramolecular hydrogelators after 2004 and to put emphasis particularly on the applications of supramolecular hydrogels/hydrogelators as molecular biomaterials. After a brief introduction of methods for generating supramolecular hydrogels, we discuss supramolecular hydrogelators on the basis of their categories, such as small organic molecules, coordination complexes, peptides, nucleobases, and saccharides. Following molecular design, we focus on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators. Particularly, we discuss the applications of supramolecular hydrogelators after they form supramolecular assemblies but prior to reaching the critical gelation concentration because this subject is less explored but may hold equally great promise for helping address fundamental questions about the mechanisms or the consequences of the self-assembly of molecules, including low molecular weight ones. Finally, we provide a perspective on supramolecular hydrogelators. We hope that this review will serve as an updated introduction and reference for researchers who are interested in exploring supramolecular hydrogelators as molecular biomaterials for addressing the societal needs at various frontiers.

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“…The efficacy of rhBMP‐2 to promote de novo bone formation has been successfully documented in the rabbit calvarial “dome model.” In titanium sealed cylinders, adding rhBMP‐2 to synthetic or bovine‐derived grafts (Polo, Lima, De Lucca, Piacezzi & Naclerio‐Homem, ), to a PEG hydrogel and HA/TCP (Jung, Weber, Thoma, Ehrbar & Cochran, ), or to a synthetic self‐assembling peptide (RADA16‐I; Ikeno, Hibi, Kinoshita, Hattori & Ueda, ) significantly increased the amount of newly formed bone. Similarly, increased bone augmentation was observed for PLLA/TCP domes loaded with rhBMP‐2 vs. non‐loaded domes (Lee, Nam, Seol, Kim & Lee, ), when a collagen sponge (ACS) loaded with rhBMP‐2 vs. a non‐loaded ACS was placed under a titanium cup (Hasegawa, Sato, Takayama, Murai & Suzuki, ), and when rhBMP‐2 with a poly(lactic‐co‐glycolic acid) copolymer/gelatin sponge (PGS) carrier was placed under a e‐PTFE mould compared with the carrier alone (Takeishi, Irie, Okuda, Ozawa & Yajima, ).…”

Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

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Effects of Self-Assembling Peptide Hydrogel Scaffold on Bone Regeneration with Recombinant Human Bone Morphogenetic Protein-2

Cited by 25 publications

References 0 publications

Vertical bone augmentation with simultaneous implantation using deproteinized bovine bone block functionalized with a slow delivery of BMP‐2

Vertical bone augmentation with simultaneous implantation using deproteinized bovine bone block functionalized with a slow delivery of BMP‐2

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

The use of bioactive factors to enhance bone regeneration: A narrative review

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