Effects of selenium supplementation on pregnancy outcomes and disease progression in HIV‐infected pregnant women in Lagos: A randomized controlled trial

Okunade, Kehinde Sharafadeen; Olowoselu, Olusola; John‐Olabode, Sarah; Hassan, Basirat O; Akinsola, O J; Nwogu, Chidinma Magnus; Ugwu, Aloy Okechukwu; Moses, Olusanjo E; Rabiu, Kabiru Afolarin; Ajepe, Adegbenga; Adenekan, Muisi A; Adejimi, Adebola A; Kanki, Phyllis J.

doi:10.1002/ijgo.13514

Cited by 10 publications

(21 citation statements)

References 22 publications

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“…These results confirm the important role of selenium, even if administered along with a multivitamin, in the maintenance of the immune system [ 223 ]. Specific trials on HIV-infected pregnant women show neither amelioration on the CD4+ cell count [ 217 ] nor decrease in the preterm delivery [ 224 ]. However, this may be due to the poor baseline nutritional status of the considered patients.…”

Section: Hivmentioning

confidence: 99%

The Role of Selenium in Pathologies: An Updated Review

2022

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Selenium is an essential microelement required for a number of biological functions. Selenium—and more specifically the amino acid selenocysteine—is present in at least 25 human selenoproteins involved in a wide variety of essential biological functions, ranging from the regulation of reactive oxygen species (ROS) concentration to the biosynthesis of hormones. These processes also play a central role in preventing and modulating the clinical outcome of several diseases, including cancer, diabetes, Alzheimer’s disease, mental disorders, cardiovascular disorders, fertility impairments, inflammation, and infections (including SARS-CoV-2). Over the past years, a number of studies focusing on the relationship between selenium and such pathologies have been reported. Generally, an adequate selenium nutritional state—and in some cases selenium supplementation—have been related to improved prognostic outcome and reduced risk of developing several diseases. On the other hand, supra-nutritional levels might have adverse effects. The results of recent studies focusing on these topics are summarized and discussed in this review, with particular emphasis on advances achieved in the last decade.

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Section: Hivmentioning

confidence: 99%

The Role of Selenium in Pathologies: An Updated Review

2022

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“…Included studies were performed in seven different countries and 18 were primary [ 34 – 39 , 41 – 48 , 51 , 53 – 55 ] while four were secondary studies [ 40 , 49 , 50 , 52 ]. Ten studies were graded as fair [ 34 , 36 , 37 , 39 , 41 – 43 , 48 , 50 , 53 ], nine as good [ 35 , 38 , 40 , 45 , 49 , 51 , 52 , 54 , 55 ], and three as excellent quality [ 44 , 46 , 47 ] ( Figure 2 ). Seventeen studies reported maternal outcomes, two reported neonatal outcomes, and three reported both.…”

Section: Resultsmentioning

confidence: 99%

“…The third trial, of excellent quality, reported that Se supplementation significantly lowered the risk of preterm delivery (relative risk 0.32, 95% confidence interval 0.11–0.96) compared to placebo. But it did not affect HIV-disease progression in pregnant women, as evidenced by no significant changes in CD4+ cell count [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes

Biswas

McLay

Campbell

2022

Journal of Nutrition and Metabolism

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Background. Several studies have suggested that increased oxidative stress during pregnancy may be associated with adverse maternal and foetal outcomes. As selenium is an essential mineral with an antioxidant role, our aim was to perform a systematic review of the existing literature reporting the effects of selenium supplementation during pregnancy on maternal and neonatal outcomes. Materials and Methods. Six electronic databases (Medline, Embase, Cochrane Library, Web of Science, Scopus, and PubMed) were searched for studies reporting the effects of selenium supplementation during pregnancy and the postpartum period on maternal and neonatal outcomes. Only randomised controlled trials on human subjects reported in English and published up to October 2021 were included. Quality assessments were conducted using the modified Downs and Black quality assessment tool. Data were extracted using a narrative synthesis. Results. Twenty-two articles were included in our systematic review (seventeen reported on maternal outcomes, two on newborn outcomes, and three on both). Maternal studies reported the effects of selenium supplementation in the prevention of thyroid dysfunction, gestational diabetes, pregnancy-induced hypertension/preeclampsia, oxidative stress, postpartum depression, premature rupture of membranes, intrauterine growth retardation, breastmilk composition, and HIV-positive women. Newborn studies reported the effects of maternal selenium supplementation on foetal oxidation stress, foetal lipid profile, neonatal hyperbilirubinemia, and newborn outcomes in HIV-positive mothers. The majority of studies were inappropriately designed to establish clinical or scientific utility. Of interest, four studies reported that selenium supplementation reduced the incidence of thyroid dysfunction and permanent hypothyroidism during the postpartum period by reducing thyroid peroxidase and thyroglobulin antibody titres. Conclusion. The evidence supporting selenium supplementation during pregnancy is poor and there is a need for appropriately designed randomised controlled trials before routine use can be recommended.

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“…Similarly, low selenium levels in HIV-infected mothers increase the risk of preterm birth and the delivery of low-birth-weight neonates. Okunade et al [48] undertook a study looking at the effects of selenium supplementation on pregnancy outcomes and disease progression in a Nigerian population of HIV-infected pregnant women. A total of 90 women were randomly assigned to receive either a daily 200 µg selenium or placebo tablet.…”

Section: Seleniummentioning

confidence: 99%

“…In Section 3.7, a study by Okunade et al [48] is referred, which demonstrated in a Nigerian population of HIV-infected pregnant women that selenium lowered the risk of preterm delivery, but had no effects on disease progression.…”

Section: Micronutrients Malaria and Hivmentioning

confidence: 99%

Do Micronutrient and Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity during Pregnancy? A Scoping Review

et al. 2022

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Maternal dietary micronutrients and omega-3 fatty acids support development of the fetal and neonatal immune system. Whether supplementation is similarly beneficial for the mother during gestation has received limited attention. A scoping review of human trials was conducted looking for evidence of biochemical, genomic, and clinical effects of supplementation on the maternal immune system. The authors explored the literature on PubMed, Cochrane Library, and Web of Science databases from 2010 to the present day using PRISMA-ScR methodology. Full-length human trials in English were searched for using general terms and vitamin A, B12, C, D, and E; choline; iodine; iron; selenium; zinc; and docosahexaenoic/eicosapentaenoic acid. Of 1391 unique articles, 36 were eligible for inclusion. Diverse biochemical and epigenomic effects of supplementation were identified that may influence innate and adaptive immunity. Possible clinical benefits were encountered in malaria, HIV infections, anemia, Type 1 diabetes mellitus, and preventing preterm delivery. Only limited publications were identified that directly explored maternal immunity in pregnancy and the effects of micronutrients. None provided a holistic perspective. It is concluded that supplementation may influence biochemical aspects of the maternal immune response and some clinical outcomes, but the evidence from this review is not sufficient to justify changes to current guidelines.

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Effects of selenium supplementation on pregnancy outcomes and disease progression in HIV‐infected pregnant women in Lagos: A randomized controlled trial

Cited by 10 publications

References 22 publications

The Role of Selenium in Pathologies: An Updated Review

The Role of Selenium in Pathologies: An Updated Review

Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes

Do Micronutrient and Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity during Pregnancy? A Scoping Review

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