Effects of Selenium Supplement on B Lymphocyte Activity in Experimental Autoimmune Thyroiditis Rats

Li, Yang; Zuo, Xuelan; Hua, Chuan; Zhao, Yong; Pei, Xiaolin; Tian, Man

doi:10.1155/2021/9439344

Cited by 6 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A booster dose was given on days 7, 14, and 21 following the initial immunization, using the same dosage but emulsifying the pTg solution with in incomplete Freund's adjuvant (IFA) rather than CFA . (12,13) .…”

Section: Methodsmentioning

confidence: 99%

The Potential Effect of Simvastatin on Regulatory T cells in Experimentally Induced Autoimmune Thyroiditis in Female Rats

Yaqeen Talib Mohammed,

Nadia Hameed Mohammed,

Inam Sameh Arif

2023

AJPS

View full text Add to dashboard Cite

Autoimmune thyroiditis also named Hashimoto's thyroiditis: is an inflammatory disorder of the thyroid gland. It is characterized by circulating antibodies to thyroid antigens, and enlargement of the gland with lymphocytic infiltration. Regulatory T cells (Tregs), a particular subset of CD4+ T cells that express CD25 at a markedly increased level. they can regulate immune response in order to preserve homeostasis and self-tolerance. T cell expansion and cytokine production are restricted by Tregs. The development of this autoimmune disease is influenced by TGF-ß1 shortage. Management of HT is usually a symptomatic therapy that concentrates on HT's symptoms rather than its underlying cause. Statins, the lipid lowering medications have pleotropic effects. they can alter immunological reactions. Twenty-four female rats were used for this experiment divided into four groups (n=6), the disease was induced in all groups except group1 (control) where rats only received phosphate buffer saline, group 2 (induction group), group 3 received Prednisolone 2mg\kg orally for 30 days and group 4 received Simvastatin (4mg\kg) orally for 30 days too. Hashimoto’s thyroiditis was induced experimentally by subcutaneous injection of porcine thyroglobulin in Freund’s adjuvant emulsion (4mg/ml). Results showed an increase in Tregs and serum TGF-ß level in rats treated with simvastatin. In conclusion, simvastatin improves the number of functioning Tregs and increases TGF-ß signaling to suppress the autoimmune reaction. Therefore, simvastatin can be a promising approach in the treatment of this disease.

show abstract

Section: Methodsmentioning

confidence: 99%

The Potential Effect of Simvastatin on Regulatory T cells in Experimentally Induced Autoimmune Thyroiditis in Female Rats

Yaqeen Talib Mohammed,

Nadia Hameed Mohammed,

Inam Sameh Arif

2023

AJPS

View full text Add to dashboard Cite

show abstract

“…The immunomodulating effect of Se on the humoral and cellular components of the autoimmune process in the thyroid gland is noted. In rats with experimental AIT, after the use of selenium yeast dietary supplement, in addition to a decrease in the levels of TgAb, TPOAb and a decrease in B-cell-activating factor (BAFF) in the blood serum, the expression of IL-10 in the thyroid tissue increased, the number of Breg in the spleen increased, and also decreased TSH level ( 77 ). Selenium increased the percentage and enhanced the activity of Treg, suppressed the secretion of pro-inflammatory cytokines, prevented the apoptosis of follicular cells and provided protection against thyroiditis ( 45 , 74 ).…”

Section: The Role Of Minerals In the Pathogenesis Of Aitd Prerequisit...mentioning

confidence: 99%

Thyroid hormones and minerals in immunocorrection of disorders in autoimmune thyroid diseases

Kravchenko,

Zakharchenko

2023

Front. Endocrinol.

View full text Add to dashboard Cite

Thyroid hormones and essential elements iodine (I), selenium (Se), iron (Fe), copper (Cu), zinc (Zn), calcium (Ca), magnesium (Mg), etc. play an important role in the work of many organs and systems of the body, including the immune system and the thyroid gland, and a violation of their supply can be the cause of pathological changes in them. In pathology, the interaction between thyroid hormones (TG), minerals and the immune system is disturbed. The review of the literature examines the immunomodulatory role of TG, minerals, their properties, and their participation in the pathogenesis of autoimmune thyroid diseases (AITD). The study of the relationship between the excess or deficiency of minerals and AITD is described. The basis of the development of AITD - Hashimoto’s thyroiditis (HT), Graves’ disease (GD), Graves’ ophthalmopathy (GO) is the loss of immune tolerance to thyroid antigens - thyroid peroxidase (TPO), thyroglobulin (Tg) and thyroid-stimulating hormone receptor (TSH-R). Immune-mediated mechanisms - production of autoantibodies to thyroid antigens and lymphocytic thyroid infiltration - are involved in the pathogenesis of AITD. Insufficiency of regulatory T cells (Treg) and regulatory B cells (Breg), imbalance between Th17-lymphocytes and Treg-lymphocytes, abnormal production of pro-inflammatory cytokines has a significant influence on the progression of AITD. With AITD, the balance between oxidants and antioxidants is disturbed and oxidative stress (OS) occurs. The lack of modern effective pharmacological therapy of AITD prompted us to consider the mechanisms of influence, possibilities of immunocorrection of pathogenetic factors using TG, micro/macronutrients. In order to develop a more effective treatment strategy, as well as approaches to prevention, a critical analysis of the ways of immunotherapeutic use of dietary supplements of I, Se, Zn, Mg and other minerals in AITD was carried out.

show abstract

“…In a rat model of experimental autoimmune thyroiditis, selenium yeast was found to partially attenuate immune imbalances, including preventing fluctuations in serum TSH [ 218 ]. Additionally, in a recent study following males with chronic autoimmune thyroiditis suffering from infertility, selenium supplementation was effective at improving sperm parameters [ 219 ].…”

Section: Signals From Brain To Bodymentioning

confidence: 99%

Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication

Toh

Nicholson

Vetter

et al. 2022

IJMS

View full text Add to dashboard Cite

The ability of the body to maintain homeostasis requires constant communication between the brain and peripheral tissues. Different organs produce signals, often in the form of hormones, which are detected by the hypothalamus. In response, the hypothalamus alters its regulation of bodily processes, which is achieved through its own pathways of hormonal communication. The generation and transmission of the molecules involved in these bi-directional axes can be affected by redox balance. The essential trace element selenium is known to influence numerous physiological processes, including energy homeostasis, through its various redox functions. Selenium must be obtained through the diet and is used to synthesize selenoproteins, a family of proteins with mainly antioxidant functions. Alterations in selenium status have been correlated with homeostatic disturbances in humans and studies with animal models of selenoprotein dysfunction indicate a strong influence on energy balance. The relationship between selenium and energy metabolism is complicated, however, as selenium has been shown to participate in multiple levels of homeostatic communication. This review discusses the role of selenium in the various pathways of communication between the body and the brain that are essential for maintaining homeostasis.

show abstract

Effects of Selenium Supplement on B Lymphocyte Activity in Experimental Autoimmune Thyroiditis Rats

Cited by 6 publications

References 34 publications

The Potential Effect of Simvastatin on Regulatory T cells in Experimentally Induced Autoimmune Thyroiditis in Female Rats

The Potential Effect of Simvastatin on Regulatory T cells in Experimentally Induced Autoimmune Thyroiditis in Female Rats

Thyroid hormones and minerals in immunocorrection of disorders in autoimmune thyroid diseases

Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication

Contact Info

Product

Resources

About