Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyroiditis

Karimi, Fariba; Omrani, Gholamhossein Ranjbar

doi:10.1007/s40618-018-0944-7

Cited by 30 publications

(18 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another important finding of the present study was the significant influence of nutritional pattern on oxidative stress parameters. Oxidative stress, defined as an imbalance between free radical production and antioxidant defense mechanisms, has been implicated in the pathogenesis of several inflammatory and immune-mediated disorders, including thyroid ADs, and the role of antioxidants is intensely debated (29,(38)(39)(40)(41)(42). Excess ROS production due to environmental agents could induce modification of tissue proteins or may dysregulate the immune system, influencing the onset of an AD.…”

Section: Discussionmentioning

confidence: 99%

Influence of Dietary Habits on Oxidative Stress Markers in Hashimoto's Thyroiditis

Ruggeri

Giovinazzo

Barbalace

et al. 2021

Thyroid

View full text Add to dashboard Cite

Background: There is a growing awareness that nutritional habits may influence risk of several inflammatory and immune-mediated disorders, including autoimmune diseases, through various mechanisms. The aim of the present study was to investigate dietary habits and their relationship with redox homeostasis in the setting of thyroid autoimmunity. Materials and Methods: Two hundred subjects (173 females and 27 males; median age, 37 years) were enrolled. None were under any pharmacological treatment. Exclusion criteria were any infectious/inflammatory/ autoimmune comorbidity, kidney failure, diabetes, and cancer. In each subject, serum thyrotropin (TSH), free thyroxine, antithyroid antibodies, and circulating oxidative stress markers were measured. A questionnaire on dietary habits, evaluating the intake frequencies of food groups and adherence to the Mediterranean diet, was submitted to each participant. Results: Among the 200 recruited subjects, 81 (71 females and 10 males) were diagnosed with euthyroid Hashimoto's thyroiditis (HT); the remaining 119 (102 females and 17 males) served as controls. In questionnaires, HT subjects reported higher intake frequencies of animal foods (meat, p = 0.0001; fish, p = 0.0001; dairy products, p = 0.004) compared with controls, who reported higher intake frequencies of plant foods (legumes, p = 0.001; fruits and vegetables, p = 0.030; nuts, p = 0.0005). The number of subjects who preferentially consumed poultry instead of red/processed meat was lower in HT subjects than in controls ( p = 0.0141). In logistic regression analysis, meat consumption was associated with increased odds ratio of developing thyroid autoimmunity, while the Mediterranean diet traits were protective. In HT subjects, serum advanced glycation end products (markers of oxidative stress) were significantly higher ( p = 0.0001) than in controls, while the activity of glutathione peroxidase and thioredoxin reductase, as well as total plasma antioxidant activity, were lower ( p = 0.020, p = 0.023, and p = 0.002, respectively), indicating a condition of oxidative stress. Stepwise regression models demonstrated a significant dependence of oxidative stress parameters on consumption of animal foods, mainly meat. Conclusions: The present study suggests a protective effect of low intake of animal foods toward thyroid autoimmunity and a positive influence of such nutritional patterns on redox balance and potentially on oxidative stress-related disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of Dietary Habits on Oxidative Stress Markers in Hashimoto's Thyroiditis

Ruggeri

Giovinazzo

Barbalace

et al. 2021

Thyroid

View full text Add to dashboard Cite

show abstract

“…Contrarily, selenium deficiency, by impairing deiodinases activity, decreases the synthesis of triiodothyronine (T3) [ 18 , 30 , 31 ]. At present, more and more studies have shown a beneficial effect of selenium supplementation on AIT and other autoimmune disorders such as asthma and rheumatoid arthritis by the improvement of autoimmune response [ 4 , 5 , 12 , 14 , 15 , 32 – 34 ]. A study conducted by Mantovani et al showed oral selenium supplementation had an effect in reducing TPOAb concentrations and the recurrence of postpartum thyroiditis during pregnancy [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Wu et al reported that the incidence of AIT is higher in the areas with selenium deficiency, but the exact mechanism remains unclear [ 10 ]. Recently, excessive oxidative stress has been implicated in the pathogenesis of AIT, and some authors support the opinion of selenium deficiency in the development of AIT and the potentially beneficial effects of selenium supplementation on AIT [ 11 – 14 ]. However, the underlying mechanisms of slowing down and preventing the development of AIT have not been fully clarified, and some studies even contrastly showed the different even opposite results.…”

Section: Introductionmentioning

confidence: 99%

Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis

Tian

et al. 2020

International Journal of Endocrinology

View full text Add to dashboard Cite

Objective. Selenium, as an antioxidant, has been implicated in the development of autoimmune thyroiditis (AIT). Many studies showed selenium supplementation could decrease thyroid autoantibodies in patients with AIT. However, the underlying mechanisms have not been well determined. Therefore, we performed a clinical study to investigate the possible mechanism of beneficial effects of selenium treatment on AIT patients. Methods. Forty euthyroid patients with AIT were randomized into two groups. Group I was treated with 200 μg/day selenium supplementation, and group II received a placebo over a 3-month period. Thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), antithyroglobulin antibody (TgAb), malondialdehyde (MDA), total antioxidant capacity (TAC), and superoxide dismutase (SOD) were measured before and 3 months after treatments. Additionally, twenty healthy volunteers also served as a control group for the evaluation of such parameters in basic condition. Results. Totally, 32 patients (group I, n = 18; group II, n = 14) completed the clinical study and were incorporated into the statistics. MDA level was higher and SOD activity and TAC were lower in patients compared to healthy individuals. After 3 months, TPOAb titer significantly decreased within group I (P<0.001) but did not change within group II (P=0.001). There were also no statistically significant changes in TSH and TgAb titers within the two groups (all P>0.05). Additionally, decreased MDA level (from 6.8 ± 1.3 nmol/ml to 4.9 ± 0.7 nmol/ml; P<0.001) and increased TAC (from 10.0 ± 1.9 mmol/l to 12.9 ± 3.1 mmol/l; P=0.003) and SOD activity (from 72.3 ± 10.3 U/ml to 84.3 ± 13.2 U/ml; P=0.007) were simultaneously observed after 3 months’ selenium treatment. Moreover, there was a negative correlation between TAC and TgAb/TPOAb and a positive correlation between MDA and TgAb/TPOAb in AIT patients. Conclusions. Our findings support the hypothesis that selenium treatment could decrease TPOAb titer via enforcing the defense against oxidative stress in euthyroid patients with AIT, which may be a potential underlying mechanism.

show abstract

“…Bonfig found that selenium supplementation with sodium selenite did not decrease TPOAb concentrations but could reduce TGAb concentrations in children and adolescents [ 30 ]. Karimi did not find any statistically significant difference in TSH and TGAb levels after sodium selenite treatment in patients with AIT [ 31 ]. Eskes conducted an RCT study in euthyroid TPOAb-positive women and concluded that six months selenium supplementation with sodium selenite had no effect on serum TPOAb and TSH levels [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Selenium Supplement on B Lymphocyte Activity in Experimental Autoimmune Thyroiditis Rats

Zuo

Hua

et al. 2021

International Journal of Endocrinology

View full text Add to dashboard Cite

Background and Objective. Thyroid is the organ with the highest selenium content in mammals, and selenium is an essential micronutrient that has close relationship with thyroid autoimmunity. However, the mechanism of how selenium modulates autoimmune thyroiditis remains to be elucidated. Thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb), which are produced by B lymphocytes, play a crucial role in autoimmune thyroiditis. The present study was aimed to investigate the effects of selenium supplement on thyroid autoimmunity and B lymphocyte activity in experimental autoimmune thyroiditis (EAT) model rats. Methods. 45 healthy and adult female SD rats were randomly divided into three groups: normal control group, EAT model group, and selenium yeast supplement EAT group. The EAT model rats were induced by subcutaneous injection of porcine thyroglobulin and fed with high iodine water. The concentrations of serum thyroid-stimulating hormone (TSH), TGAb, TPOAb, and B cell activating factor (BAFF) were detected in each group by enzyme-linked immunosorbent assay (ELISA), and the expression of interleukin-10 (IL-10) in thyroid tissue was detected by immunohistochemistry. B cells and regulatory B cells (Bregs) ratios in the spleen of rats were analyzed by flow cytometry. Results. In contrast with the EAT model group, the levels of serum TSH, TGAB, TPOAb, and BAFF were decreased, while IL-10 expression was increased in thyroid tissue, and Bregs ratio was upregulated in the spleen (all p < 0.05 ) in the selenium yeast supplement EAT group. Conclusion. Selenium yeast supplement could partially attenuate immune imbalance in EAT rats, which may be related to the mechanism of modulating B lymphocyte activity.

show abstract

Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyroiditis

Abstract: Our findings supported the hypothesis of antioxidant beneficial effects of Se in AIT. However, it was not superior to vitamin C, regarding its effects on thyroid-specific antibodies.

Cited by 30 publications

References 46 publications

Influence of Dietary Habits on Oxidative Stress Markers in Hashimoto's Thyroiditis

Influence of Dietary Habits on Oxidative Stress Markers in Hashimoto's Thyroiditis

Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis

Effects of Selenium Supplement on B Lymphocyte Activity in Experimental Autoimmune Thyroiditis Rats

Contact Info

Product

Resources

About