Effects of Selective Angiotensin II Type 1 Receptor Blockade with Losartan on Arterial Compliance in Patients with Mild Essential Hypertension

Klemsdal, Tor Ole; Moan, Andreas; Kjeldsen, Sverre E.

doi:10.1080/080370599439599

Cited by 28 publications

(1 citation statement)

References 31 publications

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“…The results of previous studies10, 11 ) are consistent with this study. Klemsdal et al10 ) reported an increase in blood vessel compliance after exercise in subjects with atherosclerosis. Koichiro et al11 ) reported on the results of a 16-week aerobic exercise program for middle-aged men.…”

Section: Discussionsupporting

confidence: 93%

Effects of endurance exercise and half-bath on body composition, cardiorespiratory system, and arterial pulse wave velocity in men with intellectual disabilities

Kim

2017

J Phys Ther Sci

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[Purpose] The purpose of this study was to investigate the effects of endurance exercise and half-bath on body composition, cardiorespiratory system, and arterial pulse wave velocity of men with intellectual disabilities. [Subjects and Methods] Twenty-four men with intellectual disabilities, but capable of learning, were randomly assigned to aerobic exercise (N=8), half-bath (N=8), or control (N=8) treatment groups. Over the 12-week treatment period, the aerobic exercise group did treadmill and stationary bicycle. The half-bath treatment group was placed in a sitting position in a 39–40°C bath for 10 minutes. [Results] The aerobic exercise group showed a significant decrease in body fat than those in the half-bath and control groups. In addition, there was an increase in the respiratory system of the aerobic exercise group but no increase in the half-bath and control groups. The arterial pulse wave velocity change was greatest in the aerobic exercise group, but the half-bath group also showed a velocity change from that in the control group. [Conclusion] Aerobic exercise and a half-bath can have positive effects on improving body composition, respiratory system, and vascular function of people with intellectual disabilities.

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Section: Discussionsupporting

confidence: 93%

Effects of endurance exercise and half-bath on body composition, cardiorespiratory system, and arterial pulse wave velocity in men with intellectual disabilities

Kim

2017

J Phys Ther Sci

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Vascular Aging

Najjar¹,

Lakatta²

Contemporary Cardiology

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Pulse Pressure in der Therapiesteuerung der Hypertonie?

Scholze

2004

Herz

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Data from the Framingham and several other studies have demonstrated a relatively consistent increase of systolic blood pressure over lifetime but a decrease of diastolic blood pressure after the age of 50-60 years-resulting in an increase of pulse pressure (PP). Epidemiologic studies in the past 10-15 years have stressed the importance of PP as an independent risk factor for cardiovascular morbidity and mortality, especially myocardial infarction and congestive heart failure.A wide clinic PP (60-65 mmHg) has been shown to be a marker of increased arterial stiffness and an elevated cardiovascular morbidity. PP is determined by combined hemodynamic cardiac (ventricular ejection) and arterial factors, like arterial stiffness as well as the timing and intensity of wave reflections. Recent careful measurements have suggested that PP is transmitted much deeper into the microcirculation, which is strongly influenced by aging, hypertension, diabetes, and renal insufficiency (endothelial dysfunction, eutrophic and hypertrophic remodeling, progressive loss of microvessels). Antihypertensive drugs may improve vascular compliance and the alterations of microvascular architecture by reducing blood pressure, relaxing vascular smooth muscle, or promoting long-term effects on extracellular matrix, collagen, vascular smooth muscle, and cardiomyocyte growth and remodeling.Diuretics, beta blockers, long-acting calcium channel blockers, angiotensin-converting enzyme (ACE) inhibitors and angiotensin I (AT(1)) receptor antagonists were critically discussed in relation to their influence on vascular compliance, endothelial dysfunction, the remodeling process, PP, and cardiovascular morbidity and mortality. The vascular protective action of some (especially AT(1) antagonists, ACE inhibitors, calcium channel blockers) but not all (beta blockers) may contribute to improve the outcome of hypertensive patients, although this is presently unproven.

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Effects of Selective Angiotensin II Type 1 Receptor Blockade with Losartan on Arterial Compliance in Patients with Mild Essential Hypertension

Cited by 28 publications

References 31 publications

Effects of endurance exercise and half-bath on body composition, cardiorespiratory system, and arterial pulse wave velocity in men with intellectual disabilities

Effects of endurance exercise and half-bath on body composition, cardiorespiratory system, and arterial pulse wave velocity in men with intellectual disabilities

Vascular Aging

Pulse Pressure in der Therapiesteuerung der Hypertonie?

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