“…33,35,36 Adherence of participants was clearly reported in all the included studies (from 67% to 96%), except four. [26][27][28]37 The PEDro score of the included studies ranged from 4 to 8 (median 6). Of the thirteen studies examined, eleven trials reported data on at least three shared outcome measures, that is, body weight in kilograms (BW); body mass index in Kg/m 2 (BMI); waist circumference in centimeters (WC); body fat mass in percentage or kilograms (BFM); heart rate peak in bpm (HR peak ) registered at cardiopulmonary exercise test (CPET); peak oxygen uptake in mL/Kg/min (VO 2peak ) at CPET; maximal exercise capacity (MExC) in watts, Abbreviations: 6MWT, six-minute walking test; ACSM, American College of Sport Medicine; AD, adherence; BBS, Berg balance scale; BFFM, body fat-free mass; BFM, body fat mass; BMI, body mass index; BW, body weight; CPET, cardiopulmonary exercise incremental test; CSST, chair sit-to-stand test; DBP, diastolic blood pressure; DO, dropout; DS, Down Syndrome; F, females; HC, hip circumference; HDL, high-density lipoprotein; HR, heart rate; hs-CRP, high sensitive C-reactive protein; ID, intellectual disability; IL-6, interleukin-6; IQ, intelligence quotient; IRM LL, maximal strength lower limb; IRM UL, maximal strength upper limb; LDL, low-density lipoprotein; M, males; MET, metabolic equivalent; MR, mental retardation; MVPA, moderate-vigorous physical activity; NR, not reported; PA, physical activity; RER, respiratory exchange ratio; RM, repetition-maximum; SBP, systolic blood pressure; TNF, tumor necrosis factor; TUG, timed up-and-go test; VAT, ventilatory anaerobic threshold; VE peak, peak minute ventilation; VO 2 peak, peak oxygen uptake; WC, waist circumference; WHR, waist hip ratio; y, years.…”