Effects of BMP‐2 on the osteogenic differentiation of bone marrow stem cells in fibrous dysplasia

Abstract

In patients with FD, stem cells in affected bone are influenced by the mutation, resulting in weak bone formation with the proliferation of immature osteogenic cells. Current treatment of FD involves surgical removal of excess bulk lesions, which can cause facial disfigurement. Our results suggest that BMP-2 application is a good adjunctive modality to the surgical treatment of patients with FD.

Carbon Monoxide-Releasing Molecule-3 Enhances Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells via miR-195-5p/Wnt3a Pathway

“… 21 Multiple biological materials and growth factors have been implemented for osteoinduction of BMSCs. 22 , 23 CORMs, a novel group of compounds that can sustainedly release CO, 24 have exhibited such potent effects as anti‑inflammatory, 25 anti-apoptotic, 26 neuroprotective, 27 vascular function improvement and so on. 24 , 28 Our previous study showed that CORM-3 promoted the osteogenic differentiation of rat BMSCs in vitro.…”

MicroRNA-195-5p regulates carbon monoxide releasing molecule-3-induced osteogenic differentiation of rat bone marrow mesenchymal stem cells by targeting Wnt3a

“…BMSCs are presently regarded as the gold standard cell source for bone tissue engineering, due to their self-renewal and multipotential differentiation capacity (Dai et al , 2018;Fuet al , 2019;Jing et al , 2019). Multiple biological materials and growth factors have been implemented for osteoinduction of BMSCs (Um et al , 2018;Zhang et al , 2016). CORMs, a novel group of compounds that are carriers of CO (Motterlini et al , 2002), have exhibited such potent effects as anti-inflammatory (Lee et al , 2018), anti-apoptotic (Ulbrich et al , 2016), neuroprotective (Ulbrich et al , 2017), vascular function improvement (Foresti et al , 2004;Motterlini et al , 2002) and so on.…”