Effects of Sauropus androgynus extract and its combination with ampicillin against Methicillin-resistant Staphylococcus aureus: An in vitro study

Rahayu, Asih; Rini, Chylen Setiyo; Prakoso, Yos Adi; Palgunadi, Bagus Uda; Munandar, Muhammad Aris

doi:10.14202/ijoh.2020.128-133

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Interestingly, the extract S. androgynus shows antibacterial activity against antibiotic-resistant bacteria such as Staphylococcus aureus AMR strain. Rahayu et al [ 192 ] demonstrated the antibacterial activity of the 60% ethanol extract of S. androgynus against methicillin-resistant, ampicillin-resistant Staphylococcus aureus strain. Bioactive components such as phenolics and flavonoids cause ultrastructural changes in the bacterial membrane which result in their growth reduction.…”

Section: Pharmacology Of Sauropus Androgynusmentioning

confidence: 99%

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

2022

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Various plants form the basis of multiple traditional ethnic cuisines and ethnomedicinal practices across the globe. The ethnic cuisines cater to the nutritional, dietary and medicinal requirements of the tribal and rural communities even today. Using literature from various scholarly databases, this study was conducted to consolidate a comprehensive review on the use of Sauropus androgynus (L.) Merr. in various traditional ethnic cuisines and ethnomedicinal preparations across the globe. The survey shows that it is used in multiple ethnic cuisines and is variously known in different countries and among the communities. Further, it possesses multiple nutritional and ethnomedicinal properties. Considering its importance in ethnic foods and ethnomedicinal preparations, it is important to investigate the nutritional composition, phytochemical constitution and pharmacological basis of ethnomedicinal uses. Therefore, we further compiled this information and found that it is a rich source of both micro- and macronutrients and packed with several bioactive compounds. Survey of pharmacological studies on its traditional medicinal uses supports its ethnomedicinal properties. Despite its importance in traditional food and ethnomedicinal systems, it remains underexplored. Limited information on the toxicity of its various extracts shows that further studies should be conducted to understand its safety aspects. Further clinical studies to prospect possible drug candidates from it should be attempted.

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Section: Pharmacology Of Sauropus Androgynusmentioning

confidence: 99%

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

2022

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Community Service Reports: Animal Health Education, Service, and Prevention of Helminthiasis in Livestock Based on Herbal Areca catechu in Desa Bodag, Kare, Madiun

Rahayu,

Prakoso,

Palgunadi

2023

Ind. Jour. Cul. Comm. Dev

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Desa Bodag, Madiun, has a large livestock population. The increase in the livestock population needs to be compensated by good management. Furthermore, this village has much areca nut (Areca catechu) production that needs to be put to good use. This community service aimed to educate, give service and promote the increase of utilization of areca nut as an anthelmintic agent in livestock. The community service was conducted in three ways: animal health education, animal health service, and educate regarding the utilization of areca nut as an anthelminthic agent. Based on the community service that has been conducted, there is 48 livestock in a single area of a farmer, consisting of 56.25% goats and 43.75% cattle. A lot of them were suffering from diseases, including helminthiasis. Based on the data, community education was performed to educate farmers about good animal health management and helminthiasis prevention using areca nuts. Animal health service was also performed in this society to mitigate livestock diseases. The community of Desa Bodag shows enthusiasm during all the community services programs, and they follow all the guidance. It is also concluded that community service in Desa Bodag has been successfully implemented. Highlights : Implementation of areca nuts as a natural anthelmintic agent, enhancing sustainable livestock health management. Focused community education on animal health and disease prevention, particularly targeting helminthiasis in livestock. Successful community engagement and adoption of new practices, demonstrating effective community service outcomes in Desa Bodag. Keywords : Livestock Management, Areca Nut, Anthelmintic Agent, Helminthiasis Prevention, Community Education

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Effect of Katuk Leaves (Sauropus androgynus) on Haematology Profile of Infected Rats with Methicillin-Resistant Staphylococcus aureus

Prakoso,

Wahyuningtyas,

Mahendra

et al. 2024

J Lab Anim. Res

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Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a formidable pathogen, causing severe infections in humans and animals, often leading to local and systemic inflammation. In light of this, it becomes imperative to explore novel therapeutic avenues. One such promising approach is the utilization of herbal-derived antioxidants, with katuk leaves (Sauropus androgynus) being a prime example. This study aimed to evaluate the efficacy of katuk leaf extract (KLE) against systemic MRSA infection in rat models. Materials and methods: This study used 36 male Sprague-Dawley rats. The rats were divided into six groups including, healthy rats (Group C), infected rats without treatment (Group K), infected rats + 100 mg vancomycin per kg BW (Group V), infected rats + 1,000 mg/kg BW of KLE (Group T1), infected rats + 2,000 mg/kg BW of KLE (Group T2), and infected rats + 4,000 mg/kg BW of KLE (Group T4). The therapy was given twice daily for seven days. On the final day, the blood and sera were collected and tested against total erythrocytes, leucocytes, indices of erythrocytes, differential leucocyte count, and C-reactive protein (CRP). Results: The findings showed that the administration of 4,000 mg/kg BW of KLE potentially leads to more favorable changes in haematological parameters compared to the healthy group, particularly for hemoglobin (Hb), packed cell volume (PCV), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), platelets, monocytes, neutrophils, and CRP. Additionally, the 4,000 mg/kg BW of KLE increases the ratio of lymphocytes/neutrophils compared to the other groups. Conclusion: The KLE has the critical benefit of being a systemic antibacterial agent against MRSA at a dosage of 4,000 mg/kg BW, especially in improving the haematological profile and CRP in rat models.

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Effects of Sauropus androgynus extract and its combination with ampicillin against Methicillin-resistant Staphylococcus aureus: An in vitro study

Cited by 3 publications

References 28 publications

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

Community Service Reports: Animal Health Education, Service, and Prevention of Helminthiasis in Livestock Based on Herbal Areca catechu in Desa Bodag, Kare, Madiun

Effect of Katuk Leaves (Sauropus androgynus) on Haematology Profile of Infected Rats with Methicillin-Resistant Staphylococcus aureus

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