Effects of S-Allylcysteine on Biomarkers of the Polyol Pathway in Rats with Type 2 Diabetes

Naidu, Parim Brahma; Uddandrao, V. V. Sathibabu; Naik, Ramavat Ravindar; Palaniyandi, Suresh S.; Munipally, Praveen Kumar; Meriga, Balaji; Begum, Mustapha Sabana; Varatharaju, Chandrasekar; Pandiyan, Rajesh; Saravanan, G.

doi:10.1016/j.jcjd.2016.03.006

Cited by 28 publications

(6 citation statements)

References 39 publications

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“…More importantly, these effects of PBGJ were more potent than those of BGJ, which might be due to the increased contents of SAC and polyphenols in PBGJ (Figure –; Table ). The antidiabetic effects of SAC have been demonstrated in both type 1 and type 2 diabetic rodent models. ,,− These studies have suggested the possible action mechanisms of SAC, particularly in STZ-induced diabetes: improving the glutathione antioxidant system, increasing leptin and adiponectin secretion, inhibiting hepatic gluconeogenesis, and suppressing nuclear factor-κB (NF-κB)-mediated inflammatory signaling. In addition, there has been strong evidence for the hypoglycemic effects of dietary polyphenols, including the improvement of β-cell function and insulin action, modulation of the enzymes involved in glucose metabolism, and reduction of intestinal absorption of dietary carbohydrate. , Along with these results, our current data suggest that SAC- and polyphenol-enriched black garlic could be a promising candidate for the control of insulin-dependent diabetes.…”

Section: Discussionmentioning

confidence: 99%

Preparation of S-Allylcysteine-Enriched Black Garlic Juice and Its Antidiabetic Effects in Streptozotocin-Induced Insulin-Deficient Mice

Kim

Cho

et al. 2017

J. Agric. Food Chem.

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S-Allylcysteine (SAC), produced in large amounts during the aging process of garlic via enzymatic hydrolysis, is known as a key compound responsible for the multiple pharmacological activities of aged black garlic. This study investigated the effects of enzyme- and high hydrostatic pressure (HHP)-assisted extraction on the content of the bioactive compounds, including SAC, in black garlic juice (BGJ) and evaluated the antidiabetic effects of SAC-enriched BGJ in streptozotocin (STZ)-treated mice. The aging process increased the contents of SAC, total polyphenols, and total flavonoids in garlic juice. More importantly, pretreatment of pectinase cocktail with HHP resulted in a greater increase in those compounds during aging. Enzyme-treated BGJ reduced hyperglycemia and improved islet architecture and β-cell function in STZ-treated mice. Moreover, these effects were more potent than those of BGJ prepared by the conventional aging process. These findings provide useful information for the production of black garlic with improved bioactivities.

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Section: Discussionmentioning

confidence: 99%

Preparation of S-Allylcysteine-Enriched Black Garlic Juice and Its Antidiabetic Effects in Streptozotocin-Induced Insulin-Deficient Mice

Kim

Cho

et al. 2017

J. Agric. Food Chem.

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“…As a result, using natural products is seen to be one of the best ways to cure cancer because it has been shown to have fewer adverse effects. Antioxidant-rich diets were employed as a cancer preventive strategy 40 .…”

Section: Resultsmentioning

confidence: 99%

Inhibition of the Growth of Tumors Induced Ehrlich Ascites by Pre-Treatment with Pomegranate and Beetroot Juice in Mice

Hemdan¹

2022

PJMHS

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The present study was to investigate the antioxidant and antitumor effects of three natural juice (pomegranate, beetroot, and both of them pomegranate and beetroot) injected with Ehrlich ascites carcinoma (EAC) - bearing female mice. The results show that pomegranate and beetroot juice extract is notable sources of phenolic acids and flavonoids. The biological experimental were distributed into six mice groups, the control negative group, and the resultant mice were injected with EAC. The mice were divided into a control EAC positive, group (3) EAC and injected with cisplatin, in addition, the EAC (4, 5, and 6) groups were separately taken orally with pomegranate, beetroot, and both pomegranate and beetroot. The total blood count, hepatic lipid peroxidation index, thiobarbituric acid-reactive substances (TBARS), catalase enzyme activity (CAT), and glutathione peroxidase (GPx) levels were evaluated, as well as liver sections were histopathological examined. In mice harboring EAC, there was a reduction in CAT and GPx activity and an increase in TBARS content. Pomegranate, beetroot, and both pomegranate and beetroot juice treatments improved the complete blood count, the negative changes in the liver enzymes, and the histopathological changes in liver sections. These improvements included increased antioxidant activities, decreased lipid peroxidation, inhibition of EAC cell proliferation, and induction of apoptosis. From the results, it could be concluded that the pomegranate and beetroot had the highest contained phenolic and flavonoid content. As a result, it can prevent the biochemical and histological alterations brought on by EAC without having any negative side effects. Keywords: Pomegranate, Beetroot juice, Ehrlich Ascites carcinoma, Cisplatian, Cancer

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“…In recent times, high glucose levels induce the activation of PKC and the increase in the levels of diacylglycerol (DAG) in a number of tissues (retina, aorta, heart, and renal glomeruli) are involved in diabetic vascular complications using diabetic animal models and patients [46][47][48]. Also, a large amount of clinical and animal experimental models implicated elevated glucose levels to be the direct activator of the polyol pathway, and it is also linked with the excessive generation of reactive oxygen species (ROS) by the activity of mitochondria, PKC, and NADPH oxidase [49,50]. Furthermore, prolonged activation of PKC has been linked to influencing the activation of a number of growth factors, i.e., platelet-derived growth factor (PDGF), transforming growth factor β (TGFβ), and vascular endothelial growth factor (VEGF) in both cultured mesangial cells and glomeruli of diabetic rats [51,52].…”

Section: Activation Of Protein Kinase C (Pkc) and Diacylglycerolmentioning

confidence: 99%

“…Recent findings have implicated PARP to be strongly associated with a myriad pathogenesis of diabetic complications, e.g., AGEs, PKC, and oxidative stress. In addition, it has been revealed to stimulate cardiac damage via its activation of NF-κB (nuclear factor κB) and also inducing the overexpression of vasoconstrictor endothelin-1 (ET-1) [49,74,75]. Furthermore, attention has shifted to PARP as one of the intense subjects in the aetiology of diabetic complications [73,74].…”

Section: Increased Intracellular Formation Of Advanced Glycationmentioning

confidence: 99%

Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review

Unuofin

Lebelo

2020

Oxidative Medicine and Cellular Longevity

161

114

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Diabetes mellitus is a metabolic disorder that majorly affects the endocrine gland, and it is symbolized by hyperglycemia and glucose intolerance owing to deficient insulin secretory responses and beta cell dysfunction. This ailment affects as many as 451 million people worldwide, and it is also one of the leading causes of death. In spite of the immense advances made in the development of orthodox antidiabetic drugs, these drugs are often considered not successful for the management and treatment of T2DM due to the myriad side effects associated with them. Thus, the exploration of medicinal herbs and natural products as therapeutic sources for the treatment of T2DM is promoted because they have little or no side effects. Bioactive molecules isolated from natural sources have been proven to lower blood glucose levels via regulating one or more of the following mechanisms: improvement of beta cell function, insulin resistance, glucose (re)absorption, and glucagon-like peptide-1 homeostasis. In recent times, the mechanisms of action of different bioactive molecules with antidiabetic properties and phytochemistry are gaining a lot of attention in the area of drug discovery. This review article presents an update of the findings from clinical research into medicinal plant therapy for T2DM.

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Effects of S-Allylcysteine on Biomarkers of the Polyol Pathway in Rats with Type 2 Diabetes

Cited by 28 publications

References 39 publications

Preparation of S-Allylcysteine-Enriched Black Garlic Juice and Its Antidiabetic Effects in Streptozotocin-Induced Insulin-Deficient Mice

Preparation of S-Allylcysteine-Enriched Black Garlic Juice and Its Antidiabetic Effects in Streptozotocin-Induced Insulin-Deficient Mice

Inhibition of the Growth of Tumors Induced Ehrlich Ascites by Pre-Treatment with Pomegranate and Beetroot Juice in Mice

Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review

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