Effects of S 15511, a therapeutic metabolite of the insulin‐sensitizing agent S 15261, in the Zucker Diabetic Fatty rat

Pickavance, Lucy; Wilding, John

doi:10.1111/j.1463-1326.2006.00586.x

Cited by 18 publications

(6 citation statements)

References 7 publications

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“…Such a decrease in insulin demand following chronic treatment with Poly-GLP-1 is in agreement with previous findings in insulin-resistant obese fa/fa Zucker rats after 6 weeks of exenatide therapy [37]. Both HOMA-IR and QUICKI are the most widely used indices for assessing insulin sensitivity, which derived from fasting glucose and insulin [38][39][40]. Although the values depend on the fasting concentrations of insulin and glucose and thereby estimate mainly hepatic insulin sensitivity [41,42], it provided additional evidence for an insulin-sensitizing effect of Poly-GLP-1 in response to exogenous insulin.…”

Section: Discussionsupporting

confidence: 91%

Poly‐GLP‐1, a novel long‐lasting glucagon‐like peptide‐1 polymer, ameliorates hyperglycaemia by improving insulin sensitivity and increasing pancreatic beta‐cell proliferation

Hui

Liu

et al. 2009

Diabetes Obesity Metabolism

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Section: Discussionsupporting

confidence: 91%

Poly‐GLP‐1, a novel long‐lasting glucagon‐like peptide‐1 polymer, ameliorates hyperglycaemia by improving insulin sensitivity and increasing pancreatic beta‐cell proliferation

Hui

Liu

et al. 2009

Diabetes Obesity Metabolism

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“…Homeostasis Model Assessment HOMA-IR was used to estimate insulin resistance [28] and was calculated as [fasting glucose (mM) × fasting insulin (μU/mL)]/22.5.…”

Section: Methodsmentioning

confidence: 99%

Long-term high-fat-diet feeding induces skeletal muscle mitochondrial biogenesis in rats in a sex-dependent and muscle-type specific manner

et al. 2012

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BackgroundMitochondrial dysfunction is thought to play a crucial role in the etiology of insulin resistance, in which skeletal muscle is the main tissue contributor. Sex differences in skeletal muscle insulin and antioxidant responses to high-fat-diet (HFD) feeding have been described. The aim of this study was to elucidate whether there is a sex dimorphism in the effects of HFD feeding on skeletal muscle mitochondrial biogenesis and on the adiponectin signaling pathway, as well as the influence of the muscle type (oxidative or glycolytic).MethodsGastrocnemius and soleus muscles of male and female Wistar rats of 2 months of age fed with a high-fat-diet (HFD) or a low fat diet for 26 weeks were used. Mitochondrial biogenesis and oxidative damage markers, oxidative capacity and antioxidant defences were analyzed. Serum insulin sensitivity parameters and the levels of proteins involved in adiponectin signaling pathway were also determined.ResultsHFD feeding induced mitochondrial biogenesis in both sexes, but to a higher degree in male rats. Although HFD female rats showed greater antioxidant protection and maintained a better insulin sensitivity profile than their male counterparts, both sexes showed an impaired response to adiponectin, which was more evident in gastrocnemius muscle.ConclusionsWe conclude that HFD rats may induce skeletal muscle mitochondrial biogenesis as an attempt to compensate the deleterious consequences of adiponectin and insulin resistance on oxidative metabolism, and that the effects of HFD feeding are sex-dependent and muscle-type specific.

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“…Homeostasis Model Assesment HOMA-β and HOMA-IR were used to estimate insulin secretion and insulin resistance, respectively [18]. HOMA-β was calculated as [20 x fasting insulin (µU/mL)]/[fasting glucose (mM) -3.5] and HOMA-IR as [fasting glucose (mM) x fasting insulin (µU/mL)]/22.5.…”

Section: Oral Glucose Tolerance Testmentioning

confidence: 99%

Gender Dimorphism in High-Fat-Diet-Induced Insulin Resistance in Skeletal Muscle of Aged Rats

Gómez-Pérez¹,

Amengual-Cladera²,

Català-Niell³

et al. 2008

Cell Physiol Biochem

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Muscle resistance to insulin plays a key role in the metabolic dysregulation associated to obesity. A pro-inflammatory and pro-oxidant status has been proposed to be the link between dietary obesity and insulin resistance. Given the gender differences previously found in mitochondrial function and oxidative stress, the aim of the present study was to investigate whether this gender dimorphism leads to differences in the development of high-fat-diet-induced insulin resistance in rat skeletal muscle. Male and female rats of 15 months of age were fed with a high-fat-diet (32% fat) for 14 weeks. Control male rats showed a more marked insulin resistance status compared to females, as indicated by the glucose tolerance curve profile and the serum insulin, resistin and adiponectin levels. High-fat-diet feeding induced an excess of body weight of 16.2% in males and 38.4% in females, an increase in both muscle mitochondrial hydrogen peroxide production and in oxidative damage, together with a decrease in the Mn-superoxide dismutase activity in both genders. However, high-fat-diet fed female rats showed a less marked insulin resistance profile than males, higher mitochondrial oxygen consumption and cytochrome c oxidase activity, and a better capacity to counteract the oxidative-stress-dependent insulin resistance through an overexpression of both muscle UCP3 and GLUT4 proteins. These results point to a gender dimorphism in the insulin resistance status and in the response of skeletal muscle to high-fat-diet feeding which could be related to a more detrimental effect of age in male rats.

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Effects of S 15511, a therapeutic metabolite of the insulin‐sensitizing agent S 15261, in the Zucker Diabetic Fatty rat

Cited by 18 publications

References 7 publications

Poly‐GLP‐1, a novel long‐lasting glucagon‐like peptide‐1 polymer, ameliorates hyperglycaemia by improving insulin sensitivity and increasing pancreatic beta‐cell proliferation

Poly‐GLP‐1, a novel long‐lasting glucagon‐like peptide‐1 polymer, ameliorates hyperglycaemia by improving insulin sensitivity and increasing pancreatic beta‐cell proliferation

Long-term high-fat-diet feeding induces skeletal muscle mitochondrial biogenesis in rats in a sex-dependent and muscle-type specific manner

Gender Dimorphism in High-Fat-Diet-Induced Insulin Resistance in Skeletal Muscle of Aged Rats

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