Effects of rosemary on lipid profile in diabetic rats

Aljamal, Abdulrahim; Ibrahim, Abdalla Mohamed; Al-Fararjeh, Mohammad A.; Alqadi, Taha

doi:10.5897/ajps11.138

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…There was no significant difference in the glucose levels of the diabetic animal groups fed on a diet supplemented with ROP as compared to the normal group. This indicates that a diet supplemented with ROP possesses a hypoglycemic effect, and this concurs with previous reports [21,22,[41][42][43][44]. In type-2 diabetes mellitus, hepatic gluconeogenesis is increased, which also aggravates the condition.…”

Section: Discussionsupporting

confidence: 92%

Diet Supplementation with Rosemary (Rosmarinus officinalis L.) Leaf Powder Exhibits an Antidiabetic Property in Streptozotocin-Induced Diabetic Male Wistar Rats

Kabubii,

Mbaria,

Mathiu

et al. 2024

Diabetology

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Diabetes mellitus is a metabolic disorder that has a high global health burden and causes high mortality and morbidity in humans. Medicinal herbs and plants offer a promising alternative to conventional therapies for the management of diabetes. Rosemary (Rosmarinus officinalis L.) is a traditional medicinal herb that has been used for the management of several diseases. Therefore, the present study investigates the antidiabetic properties of diets supplemented with R. officinalis leaf powder on streptozotocin-induced diabetic Wistar rats. First, the phytochemicals and 2,2-dephenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity of aqueous R. officinalis leaf extract were determined. Streptozotocin-induced diabetic male Wistar rats were fed a diet supplemented with R. officinalis leaf powder (ROP) at 3%, 6%, and 12%, respectively, for 6 weeks. Investigations of food intake, body weight, rat relative organ weights, blood glucose, lipid profiles, creatinine, bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were estimated according to standard procedures. The results show that ROP aqueous extract contains significant amounts of phenolics, flavonoids, and tannins, which exhibit in vitro DPPH free-radical scavenging activity. Based on an in vivo study, ROP reduced blood glucose levels in streptozotocin-induced diabetic animals (p < 0.05). Dietary supplementation with ROP in diabetic rats significantly (p < 0.05) lowered ALT, AST, bilirubin, creatinine, total triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) levels while increasing high-density lipoproteins (HDLs) when compared with the diabetic control group. Our findings demonstrate that a diet supplemented with R. officinalis leaf powder exhibits an antidiabetic potential with improved health outcomes, as demonstrated by the improved lipid and liver profile enzymes in our animal model.

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Section: Discussionsupporting

confidence: 92%

Diet Supplementation with Rosemary (Rosmarinus officinalis L.) Leaf Powder Exhibits an Antidiabetic Property in Streptozotocin-Induced Diabetic Male Wistar Rats

Kabubii,

Mbaria,

Mathiu

et al. 2024

Diabetology

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“…The lowest levels of CHO, TG, LDL and VLDL were recorded at 270 mg/kg treatment, showing decreasesby -25, -25, -41 and -28%, respectively, while HDL level was increased by 89% compared with the control treatment. These results are in agreement with the previous findings [40]that the oral administration of rosemary leaf extract caused significant declines in the blood levels of triglycerides, total cholesterol, LDL, but increased HDL. Rosemary leaf extract had a hypolipidemic potential, whichmight be an indication of progressive metabolic control of rosemary leaf extract on mechanisms involved in elimination of the lipids from the body.…”

Section: -The Effects Of Rosmarinus Officinalis On the Lipid Profilesupporting

confidence: 94%

Investigation the potential role of some medicinal plants extracts in regulating serum lipid profile in female albino rats

Hameed

Al-Shahwany

Salih

2019

eijs

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Strong evidence showed that many medicinal plants have the potential to reduce hyperlipidemia disease. The aim of this study was to determine the hypolipidemic activity of aqueous extracts of Fucus vesiculosus, Coleus forskohlii, Curcuma longa L., Rosmarinus officinalis L., Camellia sinensis L. and Melissa officinalis L. on lipid profile in serum taken from the blood of rats. Fifty-seven female albino rats were divided into 19 groups, each with three rats, that were treated orally with an aqueous plant extract in three different doses, except the control group which was treated with normal saline only. The chemical compositions of these extracts were analyzed using High Performance Liquid Chromatography (HPLC).The results showed that the dose of 5 mg/kg ofCurcuma longa was the powerful extract which reduced levels of cholesterol (CHO) and low-density lipoprotein (LDL) in serum rats' blood by 31 and 55%, respectively, compared with the control treatment. While, the effective extract to reduce triglycerides (TG) level was that ofFucus vesiculosus(50mg/kg) which reduced TG by 38% compared with the control. Also, Melissa officinalis(50 mg/kg ) extract reduced 30% of very low-density lipoprotein (VLDL) level as compared to the control treatment. In addition, Coleus forskohlii(100 mg/kg) extract increased high-density lipoprotein (HDL) level by 115% after being orally given to rats for four weeks. The results of the study indicated significant differences among the concentrationsof the secondary compoundswithin their extracts, which maybe responsible for the observed variations of hypolipidemic activity for each extract. Based on these results, further investigation should target understanding the mechanismsby which these plants can be used as food additives and as dietary supplement.

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“…The advantage of herbal medicine rises from the fact that plants contain only natural substances in contrast to synthetic drugs, which have been proved to have major side effects despite their treatment ability. Several herbs have been proved efficient in reducing high blood cholesterol, blood sugar, providing some protection against cancer and stimulating the immune system [4]. Figure 1 shows the commonly called Rosemary plant (Rosmarinus officinalis L.) native to the north and south coasts of the Mediterranean Sea, is an evergreen perennial aromatic shrub belonging to the family Labiatae [5].…”

Section: Introductionmentioning

confidence: 99%

Impact of Rosemary Leave extracts on Triacylglycerol levels in Human Serum Albumin

Z¹,

Zaida

2019

BJSTR

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In order to estimate the best affinity of rosemary extract towards the removal of triacylglycerol (TAG) from a real human serum albumin sample HSA in vitro, Rosemary leaves were obtained from Rosmarinus officinalis L plant, and rosemary extracts were prepared with four well selected ethanol-water concentrations combinations and were screened accordingly. The relative affinities of the rosemary (RM) extracts using the selected extraction solvents were evaluated spectrophotometrically and analyzed by applying a well-defined standard equation for each extract. Our results of the current study suggest that the extracts of RM plant could be considered as effective agents to remove TAG from human serum albumin in vitro. The relative affinity is dependent on the concentration of ethanol -water ratio used in the extraction procedure. The relative affinities of plant extracts in this study towards the removal of TAG showed different extends for TAG removal and were varied from 3.96 to 11.16 dependent on ethanol -water ratio. The studied extracts interacted with human serum albumin (HSA) with different binding affinities, which were directly related to their relative affinities to remove TAG from the human serum albumin sample. The present study clearly shows that the highest relative affinity was observed in 50% ethanol -water extracting solution.

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Effects of rosemary on lipid profile in diabetic rats

Cited by 7 publications

References 30 publications

Diet Supplementation with Rosemary (Rosmarinus officinalis L.) Leaf Powder Exhibits an Antidiabetic Property in Streptozotocin-Induced Diabetic Male Wistar Rats

Diet Supplementation with Rosemary (Rosmarinus officinalis L.) Leaf Powder Exhibits an Antidiabetic Property in Streptozotocin-Induced Diabetic Male Wistar Rats

Investigation the potential role of some medicinal plants extracts in regulating serum lipid profile in female albino rats

Impact of Rosemary Leave extracts on Triacylglycerol levels in Human Serum Albumin

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