Effects of Roentgen Irradiation on the Tumor Bed: II. The Inhibiting Action of Different Dose Levels of Local Pretransplantation Roentgen Irradiation on the Growth of Mouse Mammary Carcinoma

Vermund, Halvor; Stenstrom, K. W.; Mosser, Donn G.; Johnson, Eugene A.

doi:10.2307/3570424

Cited by 23 publications

(3 citation statements)

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“…The growth of both the transplanted tumours decreased in irradiated groups. This effect of whole-body irradiation is puzzling in the light of results reported by Rosenau and Moon (1967) who found an increased tumour growth after whole-body irradiation with doses tested up to 600 R. A tumour-bed effect exerted by wholebody irradiation inhibiting tumour growth does not seem very likely in our system, since such an effect has been described only after high local doses of X-irradiation, mostly above 1,000 R (Vermund et al, 1956;Summers et al, 1964;Hewitt and Blake, 1968). The decreased tumour growth might be an effect of the depressed immune reactivity of the hosts, implying that the ratio of enhancing antibody to cellular immunity is changed (cf.…”

Section: Resultscontrasting

confidence: 52%

Tumour metastasis in mice with reduced immune reactivity. I. Studies with two MCA‐induced sarcomas in radiation and thymectomized radiation C57BL/6J chimeras

Boeryd

Suurküla

1973

Intl Journal of Cancer

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Spontaneous metastasis formation from two MCA-induced sarcomas with diferent degrees of antigenicity was studied in radiation and thymectomized radiationTumour-specific immune responses are known to be able to influence the growth of transplanted tumours (Prehn and Main, 1957;Klein et al., 1960). The influence of immunologic factors on the formation of metastases has also been described. Treatment with heterologous antilymphocyte serum (ALS) has increased metastasis formation in allogeneic systems (Hellman et al., 1968;Deodhar and Crile, 1969;Gershon and Carter, 1970) and in syngeneic systems (Fisher et al., 1969). Crile and Deodhar (1971) demonstrated significant protection against metastasis formation from Sarcoma 241 in C57BL mice which were specifically immunized against the tumour.The cited literature implies an inhibitory immunological influence on the formation of metastases. The relative importance of this influence is not clear, however. The net influence of the immune response on tumour dissemination could be elucidated by studying the effects of a defined high degree of immune suppression.Thus, the aim of the present investigation was to study this problem by comparing tumour spread in intact animals with that in animals with deeply depressed immune reactivity. MATERIAL AND METHODS

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Section: Resultscontrasting

confidence: 52%

Tumour metastasis in mice with reduced immune reactivity. I. Studies with two MCA‐induced sarcomas in radiation and thymectomized radiation C57BL/6J chimeras

Boeryd

Suurküla

1973

Intl Journal of Cancer

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“…A series of papers by Vermund and his collaborators (Stenstrom et al, 1955; Vermund, Stenstrom, Mosser and Johnson, 1956;Vermund, Stenstrom, -Mosser and Loken, 1958;Vermund, 1959;Summers, Clifton and Vermund, 1964) describe studies of the TBE using various strains of mouse tumour injected as tumour pulp.…”

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confidence: 99%

The growth of transplanted murine tumours in pre-irradiated sites

Hewitt¹,

Blake²

1968

Br J Cancer

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THE obvious structural and functional interdependence of normal tissue stroma and malignant cells in solid tumours persuaded the earliest radiobiological investigators that the effect of ionising radiation on these composite structures was the resultant of separate damage to the normal and malignant tissue components. It is understandable that, with a persistent inability to quantitate separately the damage to either component, unlimited scope prevailed for the assertion of rival theories in which the response of a tumour was attributed preferentially to direct damage to one or other component. Histological study of irradiated experimental tumours is of very limited value in assessing the contribution of direct stromal damage. This follows from the fact that direct damage to blood vessels is not readily distinguishable from changes consequent on the regression of stroma which must be expected to follow the dissolution of tumour cells whose reproductive integrity has been directly damaged by the irradiation.Recent developments in the quantitative radiobiology of mammalian tumour cells irradiated in vivo have encouraged interpretations of tumour response which refer, often exclusively, to the direct effect of radiation on the clonogenic cell population of the tumour. Such exclusive consideration has undoubtedly been proved to be justified in respect of the relation between the estimated size of a tumour cell population in a tumour and the single dose of radiation required for its cure under specified conditions of oxygenation. This relation has been found to accord with the predictions of relevant radiation survival curves (Hewitt, 1963;Reinhold and De Bree, 1966), this last information being obtained under conditions where stromal changes make no contribution. Suit, Shalek and Wette (1964) conclude from their extensive dose-cure studies of murine adenocarcinoma that their results " do not indicate a tissue effect on cellular radiosensitivity, tumour bed effect on tumour curability, or non-specific host-tumour effect ".If, as it appears, radiation-induced damage to the stroma makes no measurable contribution to the eradication or " cure " of a tumour, the question remains whether such damage influences the character of the changes of tumour volume which are brought about by irradiation of a tumour in vivo. The consideration achieves particular importance when attempts are made to interpret tumour regrowth curves in terms of survival curves for the clonogenic tumour cells. Thomlinson and Craddock (1967) state that, for the rat fibrosarcoma they studied, the oxygen enhancement ratio determined from measurements of the growth response of their tumours to irradiation is considerably greater than that obtained from in vitro studies of the clonogenic cells of their tumour. They refer to capillary damage as possibly conducing to the discrepancy. Several reports have appeared of the volume response of tumours to a single or fractionated dose of

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“…Optimal schedules would likely use limited fractionated treatment schedules, leading to gradual tumor shrinkage, and repopulation would be depended upon for complete tissue healing. A 'tumor bed effect' may also alter tumor growth [81]. However, such treatment schedules for fast neutrons have led to increased biological effect (RBE) with fractionation [8] and time [67].…”

Section: Considerations In the Choice O F Particles Fast Neutrons Ormentioning

confidence: 99%

Radiobiological Considerations for Pions in Radiotherapy

Feola¹,

Maruyama²

1971

Oncology

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A new radiation beam, the π – meson beam, is being considered for radiotherapy of human neoplasms. It is clear that this beam has special attributes which make it useful in certain types of neoplasms. However, human experience is heavily based upon low LET beams, alterations of dose rate and treatment, planning to confine dose to required therapeutic volumes. The use of this new beam must be considered upon existing knowledge regarding the natural history of the neoplasms, and the expected biological properties of the pion beam. It is likely that revision of present fractionation schedules will be required but most likely the pions will be useful to treat the residual tumor core of a tumor reduced in size by prior external beam, low LET therapy.

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Effects of Roentgen Irradiation on the Tumor Bed: II. The Inhibiting Action of Different Dose Levels of Local Pretransplantation Roentgen Irradiation on the Growth of Mouse Mammary Carcinoma

Cited by 23 publications

References 1 publication

Tumour metastasis in mice with reduced immune reactivity. I. Studies with two MCA‐induced sarcomas in radiation and thymectomized radiation C57BL/6J chimeras

Tumour metastasis in mice with reduced immune reactivity. I. Studies with two MCA‐induced sarcomas in radiation and thymectomized radiation C57BL/6J chimeras

The growth of transplanted murine tumours in pre-irradiated sites

Radiobiological Considerations for Pions in Radiotherapy

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